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- W2012146877 abstract "Chloramphenicol (Ch) administration has been associated with the fetal ‘gray baby syndrome’ and depression of the hematopoetic system. Ch also causes alterations of mitochondrial morphology and interferes with mitochondrial energy metabolism in a variety of species. We have investigatged the effects of Ch on mitochondrial energy metabolism and structure in the developing chick liver. Ch and 14C-leucine were injected through shell windows into 12 to 17 day chick embryos. After 3 days of exposure to the drug the livers were fixed for electron microscopy and were also used for biochemical studies. Electron micrographs of the Ch treated livers showed major ultrastructural alterations characterized by profound mitochondrial swelling and distortions of mitochondrial structure. There was also a great abundance of free ribosomes. The cytochrome oxidase activity of the treated liver homogenates and the mitochondrial yields from Ch treated livers were approximately 40 to 50% of those of the control. Mitochondrial profiles of Ch treated liver homogenates on sucrose density gradients were greatly diffused when compared with controls, presumably because of the ultrastructural abnormalities. 14Cleucine incorporation into the Ch treated liver mitochondria separated on a sucrose density gradient was significantly less than observed with control. Those mitochondria which were isolated had some biochemical activities similar to the controls (isocitric dehydrogenase, malate dehydrogenase) but rates of oxidation with NADH limited substrates were less than control values. These data suggest that Ch may interfere with energy metabolism in rapidly proliferating tissues because of its effects on protein synthesis and mitochondrial structure and function." @default.
- W2012146877 created "2016-06-24" @default.
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- W2012146877 date "1970-09-01" @default.
- W2012146877 modified "2023-09-25" @default.
- W2012146877 title "Chloramphenicol Causes Ultrastructural and Biochemical Alterations in Developing Chick Liver" @default.
- W2012146877 doi "https://doi.org/10.1203/00006450-197009000-00035" @default.
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