FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012148214> ?p ?o ?g. }

• W2012148214 endingPage "114" @default.
• W2012148214 startingPage "107" @default.
• W2012148214 abstract "This study was undertaken to examine the effect of cyclooxygenase (COX) 2 inhibition on the development of muscular insulin resistance in high-fat-induced obese rats.The rats were on a regular chow diet (C) or high-fat enriched diet (HFD) energy-restrictedly (HFr), or ad libitum (HFa) for 12weeks. The rats fed HFD ad libitum were further divided into 3 groups: oral gavage with vehicle (HFa), selective COX-2 inhibitors-celecoxib (HFa+C) or nimesulid (HFa+N), 30mg/kg/day, respectively.Increased fasting plasma insulin, triglyceride and 8-isoprostane levels in HFa were significantly suppressed in those of HFa+C and HFa+N. The whole body insulin resistance of HFa indicated by the increased fasting plasma insulin levels and the elevated area under curve of insulin obtained from the oral glucose tolerance test were significantly reversed in those combined with celecoxib and nimesulid administration compared with those in HFr. The gene expression of COX-2 was significantly increased in epididymal fat but not in soleus muscle in HFa and the enhanced adipose COX-2 expression in high-fat fed rats was suppressed by those with drug treatment. Both selective COX-2 inhibitors reversed the diminished insulin-stimulated glucose uptake and GLUT4 translocation in skeletal muscles of HFa. Obesity-induced oxidative stress indicated by the elevated plasma 8-isoprostane,the decreased ratio of GSH/GSSG and increased TBARS in soleus muscle were significantly reversed by COX-2 inhibition.The results suggest that COX-2 inhibition might suppress the muscular insulin resistance indirectly through decreasing the COX-2-mediated systemic oxidative stress in this diet-induced obese model." @default.
• W2012148214 created "2016-06-24" @default.
• W2012148214 creator A5005779169 @default.
• W2012148214 creator A5014291268 @default.
• W2012148214 creator A5030184709 @default.
• W2012148214 creator A5042320743 @default.
• W2012148214 creator A5043658052 @default.
• W2012148214 creator A5048978489 @default.
• W2012148214 date "2011-07-01" @default.
• W2012148214 modified "2023-10-17" @default.
• W2012148214 title "The importance of cyclooxygenase 2-mediated oxidative stress in obesity-induced muscular insulin resistance in high-fat-fed rats" @default.
• W2012148214 cites W146700098 @default.
• W2012148214 cites W1565549817 @default.
• W2012148214 cites W1605488382 @default.
• W2012148214 cites W1896943975 @default.
• W2012148214 cites W1898907048 @default.
• W2012148214 cites W1963734058 @default.
• W2012148214 cites W1964498839 @default.
• W2012148214 cites W1994496611 @default.
• W2012148214 cites W2011720254 @default.
• W2012148214 cites W2035657846 @default.
• W2012148214 cites W2039774384 @default.
• W2012148214 cites W2046351137 @default.
• W2012148214 cites W2049881486 @default.
• W2012148214 cites W2059436650 @default.
• W2012148214 cites W2061962106 @default.
• W2012148214 cites W2075703747 @default.
• W2012148214 cites W2078162773 @default.
• W2012148214 cites W2091641501 @default.
• W2012148214 cites W2092545538 @default.
• W2012148214 cites W2100371568 @default.
• W2012148214 cites W2114164688 @default.
• W2012148214 cites W2116024321 @default.
• W2012148214 cites W2123167115 @default.
• W2012148214 cites W2129316761 @default.
• W2012148214 cites W2133711136 @default.
• W2012148214 cites W2134604231 @default.
• W2012148214 cites W2136024338 @default.
• W2012148214 cites W2151763612 @default.
• W2012148214 cites W2152377123 @default.
• W2012148214 cites W2169593539 @default.
• W2012148214 doi "https://doi.org/10.1016/j.lfs.2011.05.006" @default.
• W2012148214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21640730" @default.
• W2012148214 hasPublicationYear "2011" @default.
• W2012148214 type Work @default.
• W2012148214 sameAs 2012148214 @default.
• W2012148214 citedByCount "18" @default.
• W2012148214 countsByYear W20121482142012 @default.
• W2012148214 countsByYear W20121482142013 @default.
• W2012148214 countsByYear W20121482142014 @default.
• W2012148214 countsByYear W20121482142015 @default.
• W2012148214 countsByYear W20121482142016 @default.
• W2012148214 countsByYear W20121482142017 @default.
• W2012148214 countsByYear W20121482142018 @default.
• W2012148214 countsByYear W20121482142019 @default.
• W2012148214 countsByYear W20121482142022 @default.
• W2012148214 crossrefType "journal-article" @default.
• W2012148214 hasAuthorship W2012148214A5005779169 @default.
• W2012148214 hasAuthorship W2012148214A5014291268 @default.
• W2012148214 hasAuthorship W2012148214A5030184709 @default.
• W2012148214 hasAuthorship W2012148214A5042320743 @default.
• W2012148214 hasAuthorship W2012148214A5043658052 @default.
• W2012148214 hasAuthorship W2012148214A5048978489 @default.
• W2012148214 hasConcept C126322002 @default.
• W2012148214 hasConcept C134018914 @default.
• W2012148214 hasConcept C171089720 @default.
• W2012148214 hasConcept C181199279 @default.
• W2012148214 hasConcept C185592680 @default.
• W2012148214 hasConcept C2776151105 @default.
• W2012148214 hasConcept C2776188179 @default.
• W2012148214 hasConcept C2777391703 @default.
• W2012148214 hasConcept C2778163477 @default.
• W2012148214 hasConcept C2778913445 @default.
• W2012148214 hasConcept C2779306644 @default.
• W2012148214 hasConcept C2779689624 @default.
• W2012148214 hasConcept C55493867 @default.
• W2012148214 hasConcept C71924100 @default.
• W2012148214 hasConceptScore W2012148214C126322002 @default.
• W2012148214 hasConceptScore W2012148214C134018914 @default.
• W2012148214 hasConceptScore W2012148214C171089720 @default.
• W2012148214 hasConceptScore W2012148214C181199279 @default.
• W2012148214 hasConceptScore W2012148214C185592680 @default.
• W2012148214 hasConceptScore W2012148214C2776151105 @default.
• W2012148214 hasConceptScore W2012148214C2776188179 @default.
• W2012148214 hasConceptScore W2012148214C2777391703 @default.
• W2012148214 hasConceptScore W2012148214C2778163477 @default.
• W2012148214 hasConceptScore W2012148214C2778913445 @default.
• W2012148214 hasConceptScore W2012148214C2779306644 @default.
• W2012148214 hasConceptScore W2012148214C2779689624 @default.
• W2012148214 hasConceptScore W2012148214C55493867 @default.
• W2012148214 hasConceptScore W2012148214C71924100 @default.
• W2012148214 hasIssue "3-4" @default.
• W2012148214 hasLocation W20121482141 @default.
• W2012148214 hasLocation W20121482142 @default.
• W2012148214 hasOpenAccess W2012148214 @default.
• W2012148214 hasPrimaryLocation W20121482141 @default.
• W2012148214 hasRelatedWork W1988699731 @default.
• W2012148214 hasRelatedWork W2017606817 @default.

• next