FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012148601> ?p ?o ?g. }

• W2012148601 endingPage "1183" @default.
• W2012148601 startingPage "1176" @default.
• W2012148601 abstract "5,6-Dimethylxanthenone-4-acetic acid (DMXAA), a new anticancer agent developed in this centre, has an antivascular action and causes regression of transplantable murine tumours that is mediated partially by the intratumoral production of tumour necrosis factor (TNF). DMXAA activates the nuclear factor-kappaB (NF-kappaB) transcription factor, which is involved in TNF synthesis and has also been suggested to mediate resistance to TNF. We wished to determine whether tumour cell NF-kappaB activation modulated the in vitro and in vivo effects of DMXAA. We compared the response of the 70Z/3 pre-B lymphoma cell line with that of its mutant 1.3E2 sub-line, which has a defective gamma-subunit of IKK, the kinase that phosphorylates IkappaB leading to NF-kappaB activation. As shown by electrophoretic mobility shift assays (EMSAs), DMXAA induced in vitro translocation of NF-kappaB (p50 and p65 subunits) into the nucleus of 70Z/3 cells, but not of 1.3E2 cells. However, when the cell lines were then grown as subcutaneous tumours in mice and treated with DMXAA (25 mg/kg), activation of NF-kappaB was found in nuclear extracts prepared from both 70/Z3 and 1.3E2 tumours, as well as from Colon 38 tumours that were used for comparison. This suggests that DMXAA induces NF-kappaB responses in host components of the tumour. Tumours grown from both 70Z/3 and 1.3E2 cells were found to regress completely following DMXAA treatment. Thus, the antitumour action of DMXAA appears to be independent of the ability of the target tumour cell population to induce NF-kappaB expression. Moreover, activation of NF-kappaB in the tumour cell did not confer resistance to DMXAA-induced therapy." @default.
• W2012148601 created "2016-06-24" @default.
• W2012148601 creator A5036760719 @default.
• W2012148601 creator A5038498764 @default.
• W2012148601 creator A5038809508 @default.
• W2012148601 creator A5046613201 @default.
• W2012148601 creator A5052252680 @default.
• W2012148601 creator A5061684371 @default.
• W2012148601 date "2003-05-01" @default.
• W2012148601 modified "2023-09-26" @default.
• W2012148601 title "NF-kappa B activation in vivo in both host and tumour cells by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)" @default.
• W2012148601 cites W1480466711 @default.
• W2012148601 cites W1558367558 @default.
• W2012148601 cites W1586111039 @default.
• W2012148601 cites W1613192541 @default.
• W2012148601 cites W1911781926 @default.
• W2012148601 cites W1975439149 @default.
• W2012148601 cites W1975725712 @default.
• W2012148601 cites W1977348907 @default.
• W2012148601 cites W2004004350 @default.
• W2012148601 cites W2026834374 @default.
• W2012148601 cites W2032531389 @default.
• W2012148601 cites W2058010480 @default.
• W2012148601 cites W2064428124 @default.
• W2012148601 cites W2081281954 @default.
• W2012148601 cites W2082575834 @default.
• W2012148601 cites W2083731669 @default.
• W2012148601 cites W2091686839 @default.
• W2012148601 cites W2093213782 @default.
• W2012148601 cites W2101257770 @default.
• W2012148601 cites W2114918609 @default.
• W2012148601 cites W2728081960 @default.
• W2012148601 cites W4293247451 @default.
• W2012148601 doi "https://doi.org/10.1016/s0959-8049(03)00196-5" @default.
• W2012148601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12736120" @default.
• W2012148601 hasPublicationYear "2003" @default.
• W2012148601 type Work @default.
• W2012148601 sameAs 2012148601 @default.
• W2012148601 citedByCount "18" @default.
• W2012148601 countsByYear W20121486012012 @default.
• W2012148601 countsByYear W20121486012013 @default.
• W2012148601 countsByYear W20121486012014 @default.
• W2012148601 countsByYear W20121486012018 @default.
• W2012148601 countsByYear W20121486012019 @default.
• W2012148601 crossrefType "journal-article" @default.
• W2012148601 hasAuthorship W2012148601A5036760719 @default.
• W2012148601 hasAuthorship W2012148601A5038498764 @default.
• W2012148601 hasAuthorship W2012148601A5038809508 @default.
• W2012148601 hasAuthorship W2012148601A5046613201 @default.
• W2012148601 hasAuthorship W2012148601A5052252680 @default.
• W2012148601 hasAuthorship W2012148601A5061684371 @default.
• W2012148601 hasConcept C100175707 @default.
• W2012148601 hasConcept C104317684 @default.
• W2012148601 hasConcept C123298856 @default.
• W2012148601 hasConcept C153911025 @default.
• W2012148601 hasConcept C17991360 @default.
• W2012148601 hasConcept C202751555 @default.
• W2012148601 hasConcept C203014093 @default.
• W2012148601 hasConcept C207001950 @default.
• W2012148601 hasConcept C2777730290 @default.
• W2012148601 hasConcept C2779730028 @default.
• W2012148601 hasConcept C502942594 @default.
• W2012148601 hasConcept C503630168 @default.
• W2012148601 hasConcept C54355233 @default.
• W2012148601 hasConcept C55493867 @default.
• W2012148601 hasConcept C62478195 @default.
• W2012148601 hasConcept C81885089 @default.
• W2012148601 hasConcept C86339819 @default.
• W2012148601 hasConcept C86803240 @default.
• W2012148601 hasConcept C95444343 @default.
• W2012148601 hasConcept C98270193 @default.
• W2012148601 hasConcept C98274493 @default.
• W2012148601 hasConceptScore W2012148601C100175707 @default.
• W2012148601 hasConceptScore W2012148601C104317684 @default.
• W2012148601 hasConceptScore W2012148601C123298856 @default.
• W2012148601 hasConceptScore W2012148601C153911025 @default.
• W2012148601 hasConceptScore W2012148601C17991360 @default.
• W2012148601 hasConceptScore W2012148601C202751555 @default.
• W2012148601 hasConceptScore W2012148601C203014093 @default.
• W2012148601 hasConceptScore W2012148601C207001950 @default.
• W2012148601 hasConceptScore W2012148601C2777730290 @default.
• W2012148601 hasConceptScore W2012148601C2779730028 @default.
• W2012148601 hasConceptScore W2012148601C502942594 @default.
• W2012148601 hasConceptScore W2012148601C503630168 @default.
• W2012148601 hasConceptScore W2012148601C54355233 @default.
• W2012148601 hasConceptScore W2012148601C55493867 @default.
• W2012148601 hasConceptScore W2012148601C62478195 @default.
• W2012148601 hasConceptScore W2012148601C81885089 @default.
• W2012148601 hasConceptScore W2012148601C86339819 @default.
• W2012148601 hasConceptScore W2012148601C86803240 @default.
• W2012148601 hasConceptScore W2012148601C95444343 @default.
• W2012148601 hasConceptScore W2012148601C98270193 @default.
• W2012148601 hasConceptScore W2012148601C98274493 @default.
• W2012148601 hasIssue "8" @default.
• W2012148601 hasLocation W20121486011 @default.
• W2012148601 hasLocation W20121486012 @default.
• W2012148601 hasOpenAccess W2012148601 @default.
• W2012148601 hasPrimaryLocation W20121486011 @default.

• next