Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012148844> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2012148844 endingPage "144" @default.
- W2012148844 startingPage "137" @default.
- W2012148844 abstract "A well-characterized positive marker for hepatocellular differentiation would be a useful tool for the diagnosis of hepatocellular carcinoma (HCC). The recently commercially available Hep Par 1 antibody (clone OCH1E5.2.10) has been reported to be a sensitive marker for HCC in paraffin embedded sections. Of non-hepatocellular tumors, occasional carcinomas have been reported to stain, most frequently gastric adenocarcinomas. This study further evaluated the staining of this antibody on a large number of neoplasms using tissue microarray technology as well as conventional tissue sections. Six hundred seventy-six tumors, including 19 cases of HCC, were tested. Eighteen of 19 cases of HCC were positive, 3 showing <5% staining. Two cases negative on the array showed focal staining when whole tissue sections from the same tumors were used. 16 of 34 cases of gastric carcinomas gave positive reactions, 4 of these showed less than 5% staining. Staining of gastric carcinomas was not limited to signet ring-type carcinomas or to areas of hepatoid differentiation. Only 1 of 11 cases of cholangiocarcinoma showed focal staining. We also noted several other tumors to stain occasionally, including adrenal cortical carcinoma (3/13), yolk sac tumor (2/9), colonic adenocarcinoma (8/106), lung carcinoma (3/52), ovarian carcinoma (5/48), and endocervical adenocarcinoma (1/5). We did not observe staining in pancreatic carcinoma (11), renal cell carcinoma (36), breast carcinoma (85), melanoma (25), or mesothelioma (5). This study supports Hep Par 1 as a useful marker in the differential diagnosis of HCC, but with significant limitations. Cautious use of this antibody in a panel with other positive (alpha fetoprotein, CD10, polyclonal carcinoembryonic antigen) and negative (epithelial membrane antigen, monoclonal carcinoembryonic antigen, CD15) markers of hepatocellular differentiation may aid in the accurate diagnosis of HCC." @default.
- W2012148844 created "2016-06-24" @default.
- W2012148844 creator A5009700796 @default.
- W2012148844 creator A5023048831 @default.
- W2012148844 creator A5029425650 @default.
- W2012148844 creator A5053000742 @default.
- W2012148844 date "2003-02-01" @default.
- W2012148844 modified "2023-09-29" @default.
- W2012148844 title "Hep Par 1 Antibody Stain for the Differential Diagnosis of Hepatocellular Carcinoma: 676 Tumors Tested Using Tissue Microarrays and Conventional Tissue Sections" @default.
- W2012148844 cites W1979804863 @default.
- W2012148844 cites W1984108276 @default.
- W2012148844 cites W1988743038 @default.
- W2012148844 cites W2009434197 @default.
- W2012148844 cites W2043143911 @default.
- W2012148844 cites W2055113126 @default.
- W2012148844 cites W2067190395 @default.
- W2012148844 cites W2072119185 @default.
- W2012148844 cites W2078159546 @default.
- W2012148844 cites W2087810003 @default.
- W2012148844 cites W2137111114 @default.
- W2012148844 cites W2162904356 @default.
- W2012148844 cites W2165677013 @default.
- W2012148844 doi "https://doi.org/10.1097/01.mp.0000052103.13730.20" @default.
- W2012148844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12591966" @default.
- W2012148844 hasPublicationYear "2003" @default.
- W2012148844 type Work @default.
- W2012148844 sameAs 2012148844 @default.
- W2012148844 citedByCount "211" @default.
- W2012148844 countsByYear W20121488442012 @default.
- W2012148844 countsByYear W20121488442013 @default.
- W2012148844 countsByYear W20121488442014 @default.
- W2012148844 countsByYear W20121488442015 @default.
- W2012148844 countsByYear W20121488442016 @default.
- W2012148844 countsByYear W20121488442017 @default.
- W2012148844 countsByYear W20121488442018 @default.
- W2012148844 countsByYear W20121488442019 @default.
- W2012148844 countsByYear W20121488442020 @default.
- W2012148844 countsByYear W20121488442021 @default.
- W2012148844 countsByYear W20121488442022 @default.
- W2012148844 countsByYear W20121488442023 @default.
- W2012148844 crossrefType "journal-article" @default.
- W2012148844 hasAuthorship W2012148844A5009700796 @default.
- W2012148844 hasAuthorship W2012148844A5023048831 @default.
- W2012148844 hasAuthorship W2012148844A5029425650 @default.
- W2012148844 hasAuthorship W2012148844A5053000742 @default.
- W2012148844 hasBestOaLocation W20121488441 @default.
- W2012148844 hasConcept C121608353 @default.
- W2012148844 hasConcept C126322002 @default.
- W2012148844 hasConcept C142724271 @default.
- W2012148844 hasConcept C193270364 @default.
- W2012148844 hasConcept C204232928 @default.
- W2012148844 hasConcept C2777546739 @default.
- W2012148844 hasConcept C2778019345 @default.
- W2012148844 hasConcept C2780801072 @default.
- W2012148844 hasConcept C2781182431 @default.
- W2012148844 hasConcept C2781294515 @default.
- W2012148844 hasConcept C502942594 @default.
- W2012148844 hasConcept C71924100 @default.
- W2012148844 hasConcept C74864618 @default.
- W2012148844 hasConceptScore W2012148844C121608353 @default.
- W2012148844 hasConceptScore W2012148844C126322002 @default.
- W2012148844 hasConceptScore W2012148844C142724271 @default.
- W2012148844 hasConceptScore W2012148844C193270364 @default.
- W2012148844 hasConceptScore W2012148844C204232928 @default.
- W2012148844 hasConceptScore W2012148844C2777546739 @default.
- W2012148844 hasConceptScore W2012148844C2778019345 @default.
- W2012148844 hasConceptScore W2012148844C2780801072 @default.
- W2012148844 hasConceptScore W2012148844C2781182431 @default.
- W2012148844 hasConceptScore W2012148844C2781294515 @default.
- W2012148844 hasConceptScore W2012148844C502942594 @default.
- W2012148844 hasConceptScore W2012148844C71924100 @default.
- W2012148844 hasConceptScore W2012148844C74864618 @default.
- W2012148844 hasIssue "2" @default.
- W2012148844 hasLocation W20121488441 @default.
- W2012148844 hasLocation W20121488442 @default.
- W2012148844 hasOpenAccess W2012148844 @default.
- W2012148844 hasPrimaryLocation W20121488441 @default.
- W2012148844 hasRelatedWork W1497720937 @default.
- W2012148844 hasRelatedWork W2035464821 @default.
- W2012148844 hasRelatedWork W2036649240 @default.
- W2012148844 hasRelatedWork W2168881876 @default.
- W2012148844 hasRelatedWork W2362143650 @default.
- W2012148844 hasRelatedWork W2364973444 @default.
- W2012148844 hasRelatedWork W2742519752 @default.
- W2012148844 hasRelatedWork W2803530537 @default.
- W2012148844 hasRelatedWork W33978073 @default.
- W2012148844 hasRelatedWork W4241023809 @default.
- W2012148844 hasVolume "16" @default.
- W2012148844 isParatext "false" @default.
- W2012148844 isRetracted "false" @default.
- W2012148844 magId "2012148844" @default.
- W2012148844 workType "article" @default.