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- W201214889 abstract "Cardiovascular disease (CVD), including cerebrovascular disease, is the leading cause of death worldwide. Although impressive advances in the knowledge of its pathological bases have been achieved, and effective therapies are constantly being developed, CVD still represents a major burden for public health. This is probably due to the multifactorial origin of the disease and to the widespread occurrence of environmental conditions that are not suitable to the genetic programming of the cardiovascular system. In fact, dyslipidemia, diabetes, obesity, hypertension, physical inactivity, alcohol consumption, and cigarette smoking, which are the principal risk factors for CVD, persist at unacceptably high levels in the global population. In addition, some patients develop CVD in the absence of traditional risk factors. Therefore there is a need to aggressively reduce the prevalence and the cardiovascular effects of the firmly established risk factors, as well as to reveal novel biomarkers of susceptibility to this serious, life-threatening condition. The recently renewed interest in epigenetics might give clues to help with this. Epigenetic signature can contribute to the individual response to environmental stimuli, and hence also to the atherogenic response to the prolonged exposure to cardiovascular risk factors. Furthermore, epigenetics might be responsible for the transgenerational transmission of environmentally generated cardiovascular risk. Epigenetics might also favor the onset of dyslipidemias, obesity, and diabetes, conditions that increase the risk for CVD and whose variability is only partially explained by genetics. Therefore, understanding the epigenetic contribution to the onset of obesity and diabetes will enhance the diagnosis and treatment of CVD." @default.
- W201214889 created "2016-06-24" @default.
- W201214889 creator A5027814946 @default.
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- W201214889 date "2014-01-01" @default.
- W201214889 modified "2023-09-27" @default.
- W201214889 title "Cardiovascular Disease and Transgenerational Epigenetic Effects" @default.
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