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• W2012149462 abstract "Babies were eligible for randomisation in the EUNO trial if they were born inside the tertiary hospital, had a gestational age at birth of between 24 weeks and 28 weeks plus 6 days (inclusive), weighed at least 500 g, and required surfactant within 24 h of birth (prophylactically or for signs of respiratory distress). Unlike the US trials, gestational age was used instead of birthweight, since it is generally considered to better reflect the level of maturity and also to be accurately assessed in the European tertiary centres because the health systems generally allow a high level of prenatal care. Indeed, many clinical studies have shown that being born small for gestational age (SGA) increases the risk of bronchopulmonary dysplasia (BPD), including the MOSAIC cohort study1Gortner L Misselwitz B Milligan D et al.Rates of bronchopulmonary dysplasia in very preterm neonates in Europe: results from the MOSAIC cohort.Neonatology. 2010; 99: 112-117Crossref PubMed Scopus (106) Google Scholar which showed a wide variety of BPD between European countries that could be explained by different local practices. Since the EUNO trial took place in nine European countries, we looked for the reference growth charts for premature babies currently used in Europe.2Voigt M Rochow N Hesse V Olbertz D Schneider KTM Jorch G Kurzmitteilung zu den Perzentilwerten für die Körpermaβe der Neugeborenen.Z Geburtsh Neonatol. 2010; 214: 24-29Crossref PubMed Scopus (47) Google Scholar, 3AUDiPOGEtude sur la croissance foetale et infantile. Mise à jour des courbes de morphométrie néonatale. Poids, taille et périmètre crânien à la naissance de 24 à 32 semaines d'âge gestationel.http://www.audipog.net/courbes_morpho.phpGoogle Scholar, 4Lezcano A Carrascosa Longás A Ferrández Fernández D Yeste et al.Estudio transversal español de crecimiento 2008. Parte I: valores de peso y longitud en recién nacidos de 26–42 semanas de etad gestacional.An Pediatr (Barc). 2008; 68: 544-551Crossref PubMed Scopus (96) Google Scholar, 5Bertino E Spada E Occhi L et al.Neonatal anthropometric charts: the Italian neonatal study compared with other European studies.JPGN. 2010; 51: 353-361PubMed Google Scholar Although reference growth charts were issued from different European populations of neonates, 10th centile birthweights (currently chosen as a cut-off value to define SGA) were remarkably similar. Since in our study the most important group of enrolled babies originated from Germany (231 of 800 [28·9%]), we applied the German data (derived from 2·3 million neonates) to the 800 enrolled infants. Although SGA clearly decreased survival without BPD compared with not SGA, there was no effect of inhaled nitric oxide treatment (table).TableProportion of neonates alive and without bronchopulmonary dysplasia, by small-for-gestational-age (SGA) status (birthweight <10th centile)PlaceboInhaled nitric oxideOdds ratio (95% CI)SGA17/42 (40·5%)17/39 (43·6%)1·16 (0·48–2·84)Not SGA243/356 (68·3%)241/356 (67·7%)1·03 (0·74–1·43) Open table in a new tab Thus, inhaled nitric oxide at 5 ppm, started within the first 24 h after birth and continued for a median of 3 weeks, does not improve survival without BPD in very preterm neonates, including the ones born SGA. HH has received speakers' fees from Linde Gas Therapeutics. MS-L, VC, and MH have received advisory board consulting fees and travel support from INO Therapeutics. JB and JL are employees of Ikaria. J-CM has received advisory board consulting fees from Ikaria and INO Therapeutics. Inhaled nitric oxide for premature babiesJean-Christophe Mercier and co-workers, on behalf of the EUNO study group (July 31, p 346),1 report that low-dose inhaled nitric oxide for prevention of bronchopulmonary dysplasia (BPD) in very preterm neonates given early after birth does not improve survival without BPD. Full-Text PDF" @default.
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• W2012149462 date "2010-12-01" @default.
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• W2012149462 title "Inhaled nitric oxide for premature babies – Authors' reply" @default.
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• W2012149462 doi "https://doi.org/10.1016/s0140-6736(10)62258-1" @default.
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