FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012150468> ?p ?o ?g. }

• W2012150468 endingPage "746" @default.
• W2012150468 startingPage "739" @default.
• W2012150468 abstract "Satellite glial cells (SGCs) in sensory ganglia are altered structurally and biochemically as a result of nerve injury. Whereas there is ample evidence that P2 purinergic receptors in central glial cells are altered after injury, there is very little information on similar changes in SGCs, although it is well established that SGCs are endowed with P2 receptors. Using calcium imaging, we characterized changes in P2 receptors in SGCs from mouse trigeminal ganglia in short-term cultures. Seven days after the induction of submandibular inflammation with complete Freund's adjuvant, there was a marked increase in the sensitivity of SGCs to ATP, with the threshold of activation decreasing from 5 μM to 10 nM. A similar observation was made in the intact trigeminal ganglion after infra-orbital nerve axotomy. Using pharmacological tools, we investigated the receptor mechanisms underlying these changes in cultured SGCs. We found that in control tissues response to ATP was mediated by P2Y (metabotropic) receptors, whereas after inflammation the response was mediated predominantly by P2X (ionotropic) receptors. As the contribution of P2X1,3,6 receptors was excluded, and the sensitivity to a P2X7 agonist did not change after inflammation, it appears that after inflammation the responses to ATP are largely due to P2X2 and/or 5 receptors, with a possible contribution of P2X4 receptors. We conclude that inflammation induced a large increase in the sensitivity of SGCs to ATP, which involved a switch from P2Y to P2X receptors. We propose that the over 100-fold augmented sensitivity of SGCs to ATP after injury may contribute to chronic pain states." @default.
• W2012150468 created "2016-06-24" @default.
• W2012150468 creator A5009822794 @default.
• W2012150468 creator A5037970695 @default.
• W2012150468 creator A5061872657 @default.
• W2012150468 date "2011-09-01" @default.
• W2012150468 modified "2023-10-18" @default.
• W2012150468 title "Peripheral inflammation upregulates P2X receptor expression in satellite glial cells of mouse trigeminal ganglia: A calcium imaging study" @default.
• W2012150468 cites W1709464822 @default.
• W2012150468 cites W1775244163 @default.
• W2012150468 cites W1897243328 @default.
• W2012150468 cites W1964036999 @default.
• W2012150468 cites W1966117162 @default.
• W2012150468 cites W1971224680 @default.
• W2012150468 cites W1973413068 @default.
• W2012150468 cites W1975553420 @default.
• W2012150468 cites W1984025105 @default.
• W2012150468 cites W1985763589 @default.
• W2012150468 cites W1993184304 @default.
• W2012150468 cites W1993374742 @default.
• W2012150468 cites W2008172360 @default.
• W2012150468 cites W2008938605 @default.
• W2012150468 cites W2009246119 @default.
• W2012150468 cites W2017413658 @default.
• W2012150468 cites W2024952182 @default.
• W2012150468 cites W2026793904 @default.
• W2012150468 cites W2027077773 @default.
• W2012150468 cites W2029718212 @default.
• W2012150468 cites W2038471736 @default.
• W2012150468 cites W2043772697 @default.
• W2012150468 cites W2048943427 @default.
• W2012150468 cites W2054519722 @default.
• W2012150468 cites W2054732161 @default.
• W2012150468 cites W2054936919 @default.
• W2012150468 cites W2056123178 @default.
• W2012150468 cites W2056148352 @default.
• W2012150468 cites W2078031031 @default.
• W2012150468 cites W2086238867 @default.
• W2012150468 cites W2086714349 @default.
• W2012150468 cites W2088947221 @default.
• W2012150468 cites W2090227348 @default.
• W2012150468 cites W2094427593 @default.
• W2012150468 cites W2113302824 @default.
• W2012150468 cites W2118788831 @default.
• W2012150468 cites W2124502026 @default.
• W2012150468 cites W2124580120 @default.
• W2012150468 cites W2130430718 @default.
• W2012150468 cites W2130803582 @default.
• W2012150468 cites W2134331088 @default.
• W2012150468 cites W2142422949 @default.
• W2012150468 cites W2145148192 @default.
• W2012150468 cites W2153955573 @default.
• W2012150468 cites W2156346381 @default.
• W2012150468 cites W2160085502 @default.
• W2012150468 cites W2473021109 @default.
• W2012150468 doi "https://doi.org/10.1016/j.neuropharm.2011.05.019" @default.
• W2012150468 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21645532" @default.
• W2012150468 hasPublicationYear "2011" @default.
• W2012150468 type Work @default.
• W2012150468 sameAs 2012150468 @default.
• W2012150468 citedByCount "80" @default.
• W2012150468 countsByYear W20121504682012 @default.
• W2012150468 countsByYear W20121504682013 @default.
• W2012150468 countsByYear W20121504682014 @default.
• W2012150468 countsByYear W20121504682015 @default.
• W2012150468 countsByYear W20121504682016 @default.
• W2012150468 countsByYear W20121504682017 @default.
• W2012150468 countsByYear W20121504682018 @default.
• W2012150468 countsByYear W20121504682019 @default.
• W2012150468 countsByYear W20121504682020 @default.
• W2012150468 countsByYear W20121504682021 @default.
• W2012150468 countsByYear W20121504682022 @default.
• W2012150468 countsByYear W20121504682023 @default.
• W2012150468 crossrefType "journal-article" @default.
• W2012150468 hasAuthorship W2012150468A5009822794 @default.
• W2012150468 hasAuthorship W2012150468A5037970695 @default.
• W2012150468 hasAuthorship W2012150468A5061872657 @default.
• W2012150468 hasConcept C115955781 @default.
• W2012150468 hasConcept C126322002 @default.
• W2012150468 hasConcept C134018914 @default.
• W2012150468 hasConcept C160225129 @default.
• W2012150468 hasConcept C169760540 @default.
• W2012150468 hasConcept C170493617 @default.
• W2012150468 hasConcept C185592680 @default.
• W2012150468 hasConcept C26702167 @default.
• W2012150468 hasConcept C2776352249 @default.
• W2012150468 hasConcept C2776914184 @default.
• W2012150468 hasConcept C2778938600 @default.
• W2012150468 hasConcept C2779683492 @default.
• W2012150468 hasConcept C2780410667 @default.
• W2012150468 hasConcept C2780884517 @default.
• W2012150468 hasConcept C529278444 @default.
• W2012150468 hasConcept C57306754 @default.
• W2012150468 hasConcept C61174792 @default.
• W2012150468 hasConcept C71924100 @default.
• W2012150468 hasConcept C86803240 @default.
• W2012150468 hasConcept C94487597 @default.
• W2012150468 hasConcept C95444343 @default.

• next