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- W2012151487 endingPage "34" @default.
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- W2012151487 abstract "Abstract There is an overwhelming evidence that children and adults with 22q11.2 deletion syndrome (22q11.2DS) have a characteristic behavioral phenotype. In particular, there is a growing body of evidence that indicates an unequivocal association between 22q11.2DS and schizophrenia, especially in adulthood. Deletion of 22q11.2 is the third highest risk for the development of schizophrenia, with only a greater risk conferred by being the child of two parents with schizophrenia or the monozygotic co‐twin of an affected individual. Both linkage and association studies of people with schizophrenia have implicated several susceptibility genes, of which three are in the 22q11.2 region; catechol‐ o ‐methyltransferase ( COMT) , proline dehydrogenase ( PRODH ), and Gnb1L. In addition, variation in Gnb1L is associated with the presence of psychosis in males with 22q11.2DS. In mouse models of 22q11.2DS, haploinsufficiency of Tbx1 and Gnb1L is associated with reduced prepulse inhibition, a schizophrenia endophenotype. The study of 22q11.2DS provides an attractive model to increase our understanding of the development and pathogenesis of schizophrenia and other psychiatric disorders in 22q11.2DS and in wider population. © 2008 Wiley‐Liss, Inc. Dev Disabil Res Rev 2008;14:26–34." @default.
- W2012151487 created "2016-06-24" @default.
- W2012151487 creator A5027865265 @default.
- W2012151487 creator A5046063805 @default.
- W2012151487 creator A5078038071 @default.
- W2012151487 date "2008-01-01" @default.
- W2012151487 modified "2023-10-14" @default.
- W2012151487 title "Candidate genes and the behavioral phenotype in 22q11.2 deletion syndrome" @default.
- W2012151487 cites W1506409704 @default.
- W2012151487 cites W152705751 @default.
- W2012151487 cites W1544982068 @default.
- W2012151487 cites W1574054177 @default.
- W2012151487 cites W1659384861 @default.
- W2012151487 cites W1700975881 @default.
- W2012151487 cites W173676294 @default.
- W2012151487 cites W1868705038 @default.
- W2012151487 cites W1882303649 @default.
- W2012151487 cites W1967443916 @default.
- W2012151487 cites W1967450410 @default.
- W2012151487 cites W1978876953 @default.
- W2012151487 cites W1979771161 @default.
- W2012151487 cites W1983129546 @default.
- W2012151487 cites W1983623341 @default.
- W2012151487 cites W1984216350 @default.
- W2012151487 cites W1985996981 @default.
- W2012151487 cites W1986002337 @default.
- W2012151487 cites W1986059489 @default.
- W2012151487 cites W1987399844 @default.
- W2012151487 cites W1988023403 @default.
- W2012151487 cites W1996124672 @default.
- W2012151487 cites W1997489121 @default.
- W2012151487 cites W1998973094 @default.
- W2012151487 cites W1999115255 @default.
- W2012151487 cites W2001183502 @default.
- W2012151487 cites W2001243412 @default.
- W2012151487 cites W2006395252 @default.
- W2012151487 cites W2010967761 @default.
- W2012151487 cites W2011884985 @default.
- W2012151487 cites W2017480237 @default.
- W2012151487 cites W2020301473 @default.
- W2012151487 cites W2020451388 @default.
- W2012151487 cites W2020901242 @default.
- W2012151487 cites W2022961682 @default.
- W2012151487 cites W2024062662 @default.
- W2012151487 cites W2025148133 @default.
- W2012151487 cites W2025415714 @default.
- W2012151487 cites W2026585990 @default.
- W2012151487 cites W2030073944 @default.
- W2012151487 cites W2030232534 @default.
- W2012151487 cites W2031622764 @default.
- W2012151487 cites W2031639875 @default.
- W2012151487 cites W2032866243 @default.
- W2012151487 cites W2033153028 @default.
- W2012151487 cites W2033175857 @default.
- W2012151487 cites W2038043373 @default.
- W2012151487 cites W2043984459 @default.
- W2012151487 cites W2049088224 @default.
- W2012151487 cites W2051713012 @default.
- W2012151487 cites W2051776099 @default.
- W2012151487 cites W2054236226 @default.
- W2012151487 cites W2054710535 @default.
- W2012151487 cites W2054856852 @default.
- W2012151487 cites W2062643145 @default.
- W2012151487 cites W2063815735 @default.
- W2012151487 cites W2065429082 @default.
- W2012151487 cites W2066918107 @default.
- W2012151487 cites W2069923399 @default.
- W2012151487 cites W2073009537 @default.
- W2012151487 cites W2074369357 @default.
- W2012151487 cites W2075398729 @default.
- W2012151487 cites W2075698740 @default.
- W2012151487 cites W2078504022 @default.
- W2012151487 cites W2081933919 @default.
- W2012151487 cites W2084955584 @default.
- W2012151487 cites W2094002913 @default.
- W2012151487 cites W2096577768 @default.
- W2012151487 cites W2096794662 @default.
- W2012151487 cites W2098498763 @default.
- W2012151487 cites W2100040984 @default.
- W2012151487 cites W2101622575 @default.
- W2012151487 cites W2102581653 @default.
- W2012151487 cites W2106281035 @default.
- W2012151487 cites W2107932899 @default.
- W2012151487 cites W2110334080 @default.
- W2012151487 cites W2110353287 @default.
- W2012151487 cites W2113121748 @default.
- W2012151487 cites W2115094738 @default.
- W2012151487 cites W2119184077 @default.
- W2012151487 cites W2120648845 @default.
- W2012151487 cites W2122870641 @default.
- W2012151487 cites W2123282017 @default.
- W2012151487 cites W2125179509 @default.
- W2012151487 cites W2125253114 @default.
- W2012151487 cites W2125390018 @default.
- W2012151487 cites W2130718539 @default.
- W2012151487 cites W2131871863 @default.
- W2012151487 cites W2132189464 @default.
- W2012151487 cites W2132989227 @default.