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- W2012151750 abstract "Clopidogrel is a new antiplatelet agent that has replaced ticlopidine as the agent of choice to combine with aspirin for patients undergoing arterial stenting. 1 Bertrand ME Rupprecht H‐J Urban P Gerschlick AH Comparative safety of ticlopidine and clopidogrel in coronary stent patients: data from CLASSICS (Abstract). Circulation. 1999; 100: 1-620 Google Scholar , 2 Moussa I Oetgen M Roubin G et al. Effectiveness of clopidogrel and aspirin versus ticlopidine and aspirin in preventing stent thrombosis after coronary stent implantation. Circulation. 1999; 99: 2364-2366 Crossref PubMed Scopus (344) Google Scholar It is also prescribed widely as a long-term prophylactic against future vascular events for patients with symptoms due to atherothrombosis affecting the brain, heart, and limbs. Compared with aspirin, it is associated with an 8·7% (95% CI 0·3–16·5%) reduction in relative risk of serious vascular events among patients with high vascular risk. 3 CAPRIE Steering CommitteeA randomised blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet. 1996; 348: 1333-1338 Google Scholar If the baseline annual risk of vascular events is 5·8% among patients treated with aspirin, the addition of clopidogrel prevents five additional events per year for every 1000 patients treated. Furthermore, clopidogrel is as safe as aspirin; or at least it is thought to be as safe, without any excess of neutropenia or thrombocytopenia among 9553 patients who were screened before being allocated clopidogrel in a large clinical trial, and of whom 99·8% were followed-up carefully for an average of about 1·9 years. 3 CAPRIE Steering CommitteeA randomised blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet. 1996; 348: 1333-1338 Google Scholar" @default.
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- W2012151750 title "Clopidogrel and thrombotic thrombocytopenic purpura" @default.
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