FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012153360> ?p ?o ?g. }

• W2012153360 abstract "Injury to the heart can result in cardiomyocyte hypertrophy, fibrosis, and cell death. Myocarditis sometimes progresses to dilated cardiomyopathy. We previously reported that ONO-1301, a synthetic prostacyclin agonist with thromboxane-synthase inhibitory activity, promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig. Here, we investigated the therapeutic efficacy of ONO-1301 in a rat model of myosin-induced experimental autoimmune myocarditis, in which the heart transits from an acute inflammatory phase to a chronic dilated cardiomyopathy phase. Four weeks after myosin injection to Lewis rats, ONO-1301 (6 mg/kg/day) was orally administered for 4 weeks (ONO-1301 group). Hemodynamic parameters and plasma brain natriuretic peptide (BNP) level were significantly improved by ONO-1301. Histological analysis revealed that capillary density in the myocardium was significantly increased by ONO-1301. ONO-1301 increased circulating endothelial progenitor cells (EPC) as determined by FACS analysis. These beneficial effects of ONO-1301 were partially abrogated by a neutralizing anti-HGF antibody (8 mg/kg/dose). These findings indicate beneficial effects of ONO-1301 in a rat experimental autoimmune myocarditis model." @default.
• W2012153360 created "2016-06-24" @default.
• W2012153360 creator A5002896446 @default.
• W2012153360 creator A5008883232 @default.
• W2012153360 creator A5016499405 @default.
• W2012153360 creator A5026286727 @default.
• W2012153360 creator A5044995720 @default.
• W2012153360 creator A5054022807 @default.
• W2012153360 creator A5056859057 @default.
• W2012153360 creator A5062280201 @default.
• W2012153360 creator A5063483183 @default.
• W2012153360 creator A5073291028 @default.
• W2012153360 creator A5078739904 @default.
• W2012153360 creator A5081612413 @default.
• W2012153360 creator A5091249720 @default.
• W2012153360 date "2013-01-01" @default.
• W2012153360 modified "2023-09-24" @default.
• W2012153360 title "Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model" @default.
• W2012153360 cites W1496643658 @default.
• W2012153360 cites W1819324930 @default.
• W2012153360 cites W1889002087 @default.
• W2012153360 cites W1985292788 @default.
• W2012153360 cites W1987188144 @default.
• W2012153360 cites W1991237402 @default.
• W2012153360 cites W1995064151 @default.
• W2012153360 cites W2000626910 @default.
• W2012153360 cites W2004542916 @default.
• W2012153360 cites W2005782838 @default.
• W2012153360 cites W2018737874 @default.
• W2012153360 cites W2031002990 @default.
• W2012153360 cites W2034633555 @default.
• W2012153360 cites W2050247434 @default.
• W2012153360 cites W2056667423 @default.
• W2012153360 cites W2063332426 @default.
• W2012153360 cites W2063584343 @default.
• W2012153360 cites W2067490052 @default.
• W2012153360 cites W2077203655 @default.
• W2012153360 cites W2078753736 @default.
• W2012153360 cites W2088387692 @default.
• W2012153360 cites W2093196283 @default.
• W2012153360 cites W2141418895 @default.
• W2012153360 cites W2148105861 @default.
• W2012153360 cites W2149216053 @default.
• W2012153360 cites W2150190569 @default.
• W2012153360 cites W2152100793 @default.
• W2012153360 cites W2159197190 @default.
• W2012153360 cites W2169031060 @default.
• W2012153360 cites W2171717305 @default.
• W2012153360 cites W2317845988 @default.
• W2012153360 doi "https://doi.org/10.1016/j.ejphar.2012.11.045" @default.
• W2012153360 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23219794" @default.
• W2012153360 hasPublicationYear "2013" @default.
• W2012153360 type Work @default.
• W2012153360 sameAs 2012153360 @default.
• W2012153360 citedByCount "7" @default.
• W2012153360 countsByYear W20121533602013 @default.
• W2012153360 countsByYear W20121533602014 @default.
• W2012153360 countsByYear W20121533602015 @default.
• W2012153360 countsByYear W20121533602017 @default.
• W2012153360 countsByYear W20121533602018 @default.
• W2012153360 countsByYear W20121533602020 @default.
• W2012153360 crossrefType "journal-article" @default.
• W2012153360 hasAuthorship W2012153360A5002896446 @default.
• W2012153360 hasAuthorship W2012153360A5008883232 @default.
• W2012153360 hasAuthorship W2012153360A5016499405 @default.
• W2012153360 hasAuthorship W2012153360A5026286727 @default.
• W2012153360 hasAuthorship W2012153360A5044995720 @default.
• W2012153360 hasAuthorship W2012153360A5054022807 @default.
• W2012153360 hasAuthorship W2012153360A5056859057 @default.
• W2012153360 hasAuthorship W2012153360A5062280201 @default.
• W2012153360 hasAuthorship W2012153360A5063483183 @default.
• W2012153360 hasAuthorship W2012153360A5073291028 @default.
• W2012153360 hasAuthorship W2012153360A5078739904 @default.
• W2012153360 hasAuthorship W2012153360A5081612413 @default.
• W2012153360 hasAuthorship W2012153360A5091249720 @default.
• W2012153360 hasConcept C126322002 @default.
• W2012153360 hasConcept C134018914 @default.
• W2012153360 hasConcept C170493617 @default.
• W2012153360 hasConcept C2776383484 @default.
• W2012153360 hasConcept C2778198053 @default.
• W2012153360 hasConcept C2778938600 @default.
• W2012153360 hasConcept C2780875844 @default.
• W2012153360 hasConcept C2781128415 @default.
• W2012153360 hasConcept C71924100 @default.
• W2012153360 hasConceptScore W2012153360C126322002 @default.
• W2012153360 hasConceptScore W2012153360C134018914 @default.
• W2012153360 hasConceptScore W2012153360C170493617 @default.
• W2012153360 hasConceptScore W2012153360C2776383484 @default.
• W2012153360 hasConceptScore W2012153360C2778198053 @default.
• W2012153360 hasConceptScore W2012153360C2778938600 @default.
• W2012153360 hasConceptScore W2012153360C2780875844 @default.
• W2012153360 hasConceptScore W2012153360C2781128415 @default.
• W2012153360 hasConceptScore W2012153360C71924100 @default.
• W2012153360 hasFunder F4320320912 @default.
• W2012153360 hasLocation W20121533601 @default.
• W2012153360 hasLocation W20121533602 @default.
• W2012153360 hasOpenAccess W2012153360 @default.
• W2012153360 hasPrimaryLocation W20121533601 @default.
• W2012153360 hasRelatedWork W1974981189 @default.
• W2012153360 hasRelatedWork W1994283109 @default.

• next