FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012153374> ?p ?o ?g. }

• W2012153374 endingPage "1740" @default.
• W2012153374 startingPage "1736" @default.
• W2012153374 abstract "PURPOSE: To evaluate the effects of ethanol exposure of the cornea on inflammation in corneal epithelium. SETTING: Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan. METHODS: One cornea of Wistar rats (n = 60) was exposed to ethanol 20% for 30 seconds. The animals were killed 0.5, 1.0, 1.5, 2.0, 6.0, 12.0, 24.0, 48.0, or 72.0 hours or 7 days after treatment. The paraffin section or cryosection of the treated eyes was processed for histology; immunohistochemistry for cyclooxygenase 2 (COX2); p65 subunit of nuclear factor kappa B (NF-κB), which is the major transcription factor involved in COX2 expression; phospho-IκB; or in situ hybridization for COX2 mRNA. RESULTS: In the uninjured corneas, faint immunoreactivity for COX2 was detected in the basal cells of the corneal epithelium, but not in other cell layers. Cyclooxygenase 2 mRNA was not observed in the injured epithelium; it was expressed 2 hours after ethanol exposure, but not 3 hours or later after treatment. The COX2 protein was detected in the corneal epithelium throughout the epithelial layers from 3 to 72 hours, but not at 7 days. The p65 of NF-κB translocated to the nuclei of corneal epithelium 3 to 24 hours after treatment but was not seen in the nuclei 48 hours after treatment. Phospho-I κB was detected in corneal epithelium 6 hours after treatment, but not 12 hours or later. CONCLUSION: Ethanol exposure activated NF-κB and upregulated COX2 expression, which may cause inflammation in corneal tissue." @default.
• W2012153374 created "2016-06-24" @default.
• W2012153374 creator A5001092223 @default.
• W2012153374 creator A5006761240 @default.
• W2012153374 creator A5020350629 @default.
• W2012153374 creator A5029765609 @default.
• W2012153374 creator A5029930536 @default.
• W2012153374 creator A5060322837 @default.
• W2012153374 creator A5064303731 @default.
• W2012153374 creator A5083152036 @default.
• W2012153374 creator A5085901705 @default.
• W2012153374 date "2006-10-01" @default.
• W2012153374 modified "2023-09-25" @default.
• W2012153374 title "Cyclooxygenase 2 expression in rat corneas after ethanol exposure" @default.
• W2012153374 cites W135298340 @default.
• W2012153374 cites W1496742383 @default.
• W2012153374 cites W1964300957 @default.
• W2012153374 cites W1964520877 @default.
• W2012153374 cites W1966051552 @default.
• W2012153374 cites W1994958717 @default.
• W2012153374 cites W2001723288 @default.
• W2012153374 cites W2008199540 @default.
• W2012153374 cites W2008424322 @default.
• W2012153374 cites W2011459325 @default.
• W2012153374 cites W2021447146 @default.
• W2012153374 cites W2024553646 @default.
• W2012153374 cites W2031736390 @default.
• W2012153374 cites W2040211695 @default.
• W2012153374 cites W2054290562 @default.
• W2012153374 cites W2058118671 @default.
• W2012153374 cites W2058746339 @default.
• W2012153374 cites W2059822562 @default.
• W2012153374 cites W2079448855 @default.
• W2012153374 cites W2098137388 @default.
• W2012153374 cites W2114033840 @default.
• W2012153374 cites W2116821504 @default.
• W2012153374 cites W2117050405 @default.
• W2012153374 cites W2125376440 @default.
• W2012153374 cites W2147567242 @default.
• W2012153374 cites W2148674446 @default.
• W2012153374 cites W2149876480 @default.
• W2012153374 cites W2258357996 @default.
• W2012153374 cites W2322226821 @default.
• W2012153374 cites W2376429513 @default.
• W2012153374 cites W2397536915 @default.
• W2012153374 cites W2401462102 @default.
• W2012153374 cites W2431081926 @default.
• W2012153374 cites W336744490 @default.
• W2012153374 doi "https://doi.org/10.1016/j.jcrs.2006.05.005" @default.
• W2012153374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17010876" @default.
• W2012153374 hasPublicationYear "2006" @default.
• W2012153374 type Work @default.
• W2012153374 sameAs 2012153374 @default.
• W2012153374 citedByCount "12" @default.
• W2012153374 countsByYear W20121533742012 @default.
• W2012153374 countsByYear W20121533742013 @default.
• W2012153374 countsByYear W20121533742016 @default.
• W2012153374 countsByYear W20121533742019 @default.
• W2012153374 crossrefType "journal-article" @default.
• W2012153374 hasAuthorship W2012153374A5001092223 @default.
• W2012153374 hasAuthorship W2012153374A5006761240 @default.
• W2012153374 hasAuthorship W2012153374A5020350629 @default.
• W2012153374 hasAuthorship W2012153374A5029765609 @default.
• W2012153374 hasAuthorship W2012153374A5029930536 @default.
• W2012153374 hasAuthorship W2012153374A5060322837 @default.
• W2012153374 hasAuthorship W2012153374A5064303731 @default.
• W2012153374 hasAuthorship W2012153374A5083152036 @default.
• W2012153374 hasAuthorship W2012153374A5085901705 @default.
• W2012153374 hasConcept C104317684 @default.
• W2012153374 hasConcept C105580179 @default.
• W2012153374 hasConcept C118487528 @default.
• W2012153374 hasConcept C126322002 @default.
• W2012153374 hasConcept C142724271 @default.
• W2012153374 hasConcept C185592680 @default.
• W2012153374 hasConcept C204232928 @default.
• W2012153374 hasConcept C2776882836 @default.
• W2012153374 hasConcept C2778024521 @default.
• W2012153374 hasConcept C2779257441 @default.
• W2012153374 hasConcept C2779306644 @default.
• W2012153374 hasConcept C529295009 @default.
• W2012153374 hasConcept C55493867 @default.
• W2012153374 hasConcept C57742111 @default.
• W2012153374 hasConcept C71924100 @default.
• W2012153374 hasConcept C81439078 @default.
• W2012153374 hasConcept C86803240 @default.
• W2012153374 hasConceptScore W2012153374C104317684 @default.
• W2012153374 hasConceptScore W2012153374C105580179 @default.
• W2012153374 hasConceptScore W2012153374C118487528 @default.
• W2012153374 hasConceptScore W2012153374C126322002 @default.
• W2012153374 hasConceptScore W2012153374C142724271 @default.
• W2012153374 hasConceptScore W2012153374C185592680 @default.
• W2012153374 hasConceptScore W2012153374C204232928 @default.
• W2012153374 hasConceptScore W2012153374C2776882836 @default.
• W2012153374 hasConceptScore W2012153374C2778024521 @default.
• W2012153374 hasConceptScore W2012153374C2779257441 @default.
• W2012153374 hasConceptScore W2012153374C2779306644 @default.
• W2012153374 hasConceptScore W2012153374C529295009 @default.
• W2012153374 hasConceptScore W2012153374C55493867 @default.

• next