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- W2012154031 abstract "Despite recent methodological advances in inferring the time-scale of biological evolution from molecular data, the fundamental question of whether our substitution models are sufficiently well specified to accurately estimate branch-lengths has received little attention. I examine this implicit assumption of all molecular dating methods, on a vertebrate mitochondrial protein-coding dataset. Comparison with analyses in which the data are RY-coded (AG --> R; CT --> Y) suggests that even rates-across-sites maximum likelihood greatly under-compensates for multiple substitutions among the standard (ACGT) NT-coded data, which has been subject to greater phylogenetic signal erosion. Accordingly, the fossil record indicates that branch-lengths inferred from the NT-coded data translate into divergence time overestimates when calibrated from deeper in the tree. Intriguingly, RY-coding led to the opposite result. The underlying NT and RY substitution model misspecifications likely relate respectively to hidden rate heterogeneity and changes in substitution processes across the tree, for which I provide simulated examples. Given the magnitude of the inferred molecular dating errors, branch-length estimation biases may partly explain current conflicts with some palaeontological dating estimates." @default.
- W2012154031 created "2016-06-24" @default.
- W2012154031 creator A5049424181 @default.
- W2012154031 date "2009-07-01" @default.
- W2012154031 modified "2023-10-02" @default.
- W2012154031 title "Branch-length estimation bias misleads molecular dating for a vertebrate mitochondrial phylogeny" @default.
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- W2012154031 doi "https://doi.org/10.1016/j.gene.2008.08.017" @default.
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