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- W2012154132 abstract "Previous work suggests that protein kinase M zeta (PKMζ) is required for long-term memory maintenance. Here, the authors find that, under some conditions, PKMζ inhibition does not erase memory, but only temporarily disrupts the expression of memory. We examined whether protein kinase M zeta (PKMζ) inhibition in the amygdala permanently disrupts fear memory by testing retention at various intervals after PKMζ blockade. Although the expression of fear memory was disrupted when the inhibitor was applied shortly before testing, it had no effect when rats were tested with longer retention intervals. These results suggest that PKMζ inhibition does not erase memory, but temporarily disrupts expression of memory." @default.
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- W2012154132 date "2011-01-23" @default.
- W2012154132 modified "2023-09-29" @default.
- W2012154132 title "Temporary disruption of fear-potentiated startle following PKMζ inhibition in the amygdala" @default.
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- W2012154132 doi "https://doi.org/10.1038/nn.2745" @default.
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