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• W2012157913 endingPage "2175" @default.
• W2012157913 startingPage "2161" @default.
• W2012157913 abstract "The helix-forming tendency of seven peptide fragments corresponding with the entire sequence of the FK506 binding protein (FKBP) has been investigated in aqueous buffer and in 2,2,2-trifluoroethanol (TFE) using CD and NMR spectroscopy. All fragments exhibited random coil conformations in aqueous buffer, whereas the amount of helix induced in the peptide fragments by TFE varied. The fragment with the highest degree of helicity in TFE corresponded with the single (α-helix in native FKBP. Fragments corresponding with β-strands 2 and 3 also exhibited strong propensity towards helix formation. In contrast, the fragment corresponding with β-strand 1 did not form helix in TFE. The inherent helix-forming tendencies are interpreted in light of the native structure to suggest possible folding nucleation sites. Conformational sampling in each peptide fragment was also compared with that observed in urea-denatured FKBP. With the exception of the fragment corresponding with β-strand 2, the formation of helical structures in the peptide fragments in TFE was correlated with the observation of turn and/or helix conformers in urea-unfolded FKBP. Surprisingly, peptide fragments in aqueous solution were less structured than the corresponding regions in urea-denatured FKBP. The conformational differences between the peptide fragments and unfolded FKBP were not due to the urea buffer or to differences in their rotational correlation times. We conclude that local amino acid interactions are not generally sufficient to account for the formation of non-random conformations in unfolded FKBP. Formation of non-random structures in unfolded FKBP may require stabilization of incipient turn or helical conformations through transient contact with non-local non-polar residues." @default.
• W2012157913 created "2016-06-24" @default.
• W2012157913 creator A5016752282 @default.
• W2012157913 creator A5047210388 @default.
• W2012157913 date "1999-02-01" @default.
• W2012157913 modified "2023-09-27" @default.
• W2012157913 title "Conformations of peptide fragments from the FK506 binding protein: comparison with the native and urea-unfolded states 1 1Edited by P. E. Wright" @default.
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