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• W2012158181 abstract "Fibroblast and/or lymphoblastoid lines from patients with several inherited primary neuronal degenerations are hypersensitive to DNA-damaging agents. Therefore, lymphoblastoid lines were irradiated from patients with sporadic Parkinson9s disease (PD), Alzheimer9s disease, and amyotrophic lateral sclerosis. The mean survival values of the eight Parkinson9s disease and of the six Alzheimer9s disease lines, but not of the five amyotrophic lateral sclerosis lines, were less than that of the 28 normal lines. Our results with Parkinson9s disease and Alzheimer9s disease cells can be explained by a genetic defect arising as a somatic mutation during embryogenesis, causing defective repair of the X-ray type of DNA damage. Such a DNA repair defect could cause an abnormal accumulation of spontaneously occurring DNA damage in Parkinson9s disease and Alzheimer9s disease neurons in vivo, resulting in their premature death." @default.
• W2012158181 created "2016-06-24" @default.
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• W2012158181 date "1985-09-01" @default.
• W2012158181 modified "2023-09-23" @default.
• W2012158181 title "Parkinson's disease and Alzheimer's disease: hypersensitivity to X rays in cultured cell lines." @default.
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• W2012158181 doi "https://doi.org/10.1136/jnnp.48.9.916" @default.
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