FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012159432> ?p ?o ?g. }

• W2012159432 endingPage "1319" @default.
• W2012159432 startingPage "1311" @default.
• W2012159432 abstract "Autosomal-dominant polycystic kidney disease results in renal failure at a varying age from childhood to old age. We postulated that factors other than the culprit gene alone contribute to the course of progression of the renal failure. We studied 580 subjects with autosomal-dominant polycystic kidney disease and 194 unaffected family members. We calculated survival curves to end-stage renal failure or death and developed a linear model for testing the effects of single or multiple variables on the progression of renal failure as estimated from the reciprocal of serum creatinine. Fifty-two subjects died and 94 reached end-stage renal failure during the period of observation, yielding functional survivals of 71% at age 50 years, 53% at 58 years and 23% at 70 years. The following variables were independently associated with worse mean renal function at a given age (P value less than 0.01): the PKD1 gene, younger age at diagnosis, male gender, hypertension, increased left ventricular mass, hepatic cysts in women, three or more pregnancies, gross hematuria, urinary tract infections in men and renal size expressed as renal volume. The following were not associated significantly with the course of renal function: gender of affected parent, mitral valve prolapse, intracranial aneurysms, any pregnancy, hepatic cysts in men and urinary tract infections in women. The identification of unalterable maleficent factors such as the PKD1 gene and male gender permit more informed counseling while the identification of alterable factors such as hypertension, number of pregnancies and recurrent urinary tract infections provides the clinician with the opportunity to modify these factors and improve the management of patients with autosomal-dominant polycystic kidney disease." @default.
• W2012159432 created "2016-06-24" @default.
• W2012159432 creator A5003104279 @default.
• W2012159432 creator A5012797653 @default.
• W2012159432 creator A5047377839 @default.
• W2012159432 creator A5074914737 @default.
• W2012159432 creator A5088742899 @default.
• W2012159432 creator A5089261327 @default.
• W2012159432 creator A5089666558 @default.
• W2012159432 date "1992-05-01" @default.
• W2012159432 modified "2023-10-18" @default.
• W2012159432 title "Factors affecting the progression of renal disease in autosomal-dominant polycystic kidney disease" @default.
• W2012159432 cites W1966368812 @default.
• W2012159432 cites W1981951415 @default.
• W2012159432 cites W1985930065 @default.
• W2012159432 cites W1987101515 @default.
• W2012159432 cites W1988192546 @default.
• W2012159432 cites W1993506505 @default.
• W2012159432 cites W1995934832 @default.
• W2012159432 cites W2002565840 @default.
• W2012159432 cites W2007225462 @default.
• W2012159432 cites W2009137611 @default.
• W2012159432 cites W2015972217 @default.
• W2012159432 cites W2017806334 @default.
• W2012159432 cites W2021594260 @default.
• W2012159432 cites W2023247388 @default.
• W2012159432 cites W2036329296 @default.
• W2012159432 cites W2036372084 @default.
• W2012159432 cites W2048168245 @default.
• W2012159432 cites W2055919114 @default.
• W2012159432 cites W2069142242 @default.
• W2012159432 cites W2074266002 @default.
• W2012159432 cites W2082527504 @default.
• W2012159432 cites W2085868009 @default.
• W2012159432 cites W2093986262 @default.
• W2012159432 cites W2142635246 @default.
• W2012159432 cites W2180745593 @default.
• W2012159432 cites W2315872644 @default.
• W2012159432 cites W2743224 @default.
• W2012159432 cites W4293241248 @default.
• W2012159432 doi "https://doi.org/10.1038/ki.1992.195" @default.
• W2012159432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1614046" @default.
• W2012159432 hasPublicationYear "1992" @default.
• W2012159432 type Work @default.
• W2012159432 sameAs 2012159432 @default.
• W2012159432 citedByCount "443" @default.
• W2012159432 countsByYear W20121594322012 @default.
• W2012159432 countsByYear W20121594322013 @default.
• W2012159432 countsByYear W20121594322014 @default.
• W2012159432 countsByYear W20121594322015 @default.
• W2012159432 countsByYear W20121594322016 @default.
• W2012159432 countsByYear W20121594322017 @default.
• W2012159432 countsByYear W20121594322018 @default.
• W2012159432 countsByYear W20121594322019 @default.
• W2012159432 countsByYear W20121594322020 @default.
• W2012159432 countsByYear W20121594322021 @default.
• W2012159432 countsByYear W20121594322022 @default.
• W2012159432 countsByYear W20121594322023 @default.
• W2012159432 crossrefType "journal-article" @default.
• W2012159432 hasAuthorship W2012159432A5003104279 @default.
• W2012159432 hasAuthorship W2012159432A5012797653 @default.
• W2012159432 hasAuthorship W2012159432A5047377839 @default.
• W2012159432 hasAuthorship W2012159432A5074914737 @default.
• W2012159432 hasAuthorship W2012159432A5088742899 @default.
• W2012159432 hasAuthorship W2012159432A5089261327 @default.
• W2012159432 hasAuthorship W2012159432A5089666558 @default.
• W2012159432 hasBestOaLocation W20121594321 @default.
• W2012159432 hasConcept C100773827 @default.
• W2012159432 hasConcept C126322002 @default.
• W2012159432 hasConcept C126894567 @default.
• W2012159432 hasConcept C159641895 @default.
• W2012159432 hasConcept C164705383 @default.
• W2012159432 hasConcept C2776266639 @default.
• W2012159432 hasConcept C2779134260 @default.
• W2012159432 hasConcept C2780091579 @default.
• W2012159432 hasConcept C2780145431 @default.
• W2012159432 hasConcept C2780306776 @default.
• W2012159432 hasConcept C71924100 @default.
• W2012159432 hasConcept C77411442 @default.
• W2012159432 hasConcept C90924648 @default.
• W2012159432 hasConceptScore W2012159432C100773827 @default.
• W2012159432 hasConceptScore W2012159432C126322002 @default.
• W2012159432 hasConceptScore W2012159432C126894567 @default.
• W2012159432 hasConceptScore W2012159432C159641895 @default.
• W2012159432 hasConceptScore W2012159432C164705383 @default.
• W2012159432 hasConceptScore W2012159432C2776266639 @default.
• W2012159432 hasConceptScore W2012159432C2779134260 @default.
• W2012159432 hasConceptScore W2012159432C2780091579 @default.
• W2012159432 hasConceptScore W2012159432C2780145431 @default.
• W2012159432 hasConceptScore W2012159432C2780306776 @default.
• W2012159432 hasConceptScore W2012159432C71924100 @default.
• W2012159432 hasConceptScore W2012159432C77411442 @default.
• W2012159432 hasConceptScore W2012159432C90924648 @default.
• W2012159432 hasIssue "5" @default.
• W2012159432 hasLocation W20121594321 @default.
• W2012159432 hasLocation W20121594322 @default.
• W2012159432 hasOpenAccess W2012159432 @default.
• W2012159432 hasPrimaryLocation W20121594321 @default.

• next