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- W2012161073 abstract "The effect of ribose(O2′)-methylation on the stability of (O2′)-methylated polyribonucleotide helices has been studied by conformational energy calculations. The preferred orientation of the methyl group is found to further stabilize the helical phosphodiester conformation (g−,g−) due to the enhanced short-range interactions arising between the methyl groups and the adjacent ribose moieties. The experimentally observed increase in melting temperature of (O2′)-alkylated polyribonucleotides is thus attributable to the enhanced stability of the helical backbone conformation." @default.
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- W2012161073 title "Effect of O(2?)-methylation on the stability of polynucleotide helices" @default.
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- W2012161073 doi "https://doi.org/10.1002/bip.1979.360181106" @default.
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