FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012161211> ?p ?o ?g. }

• W2012161211 endingPage "597" @default.
• W2012161211 startingPage "589" @default.
• W2012161211 abstract "Stereotaxic injections of a dopamine D1 receptor agonist (SKF 38393) into different regions of the supersensitive striatum of rats with a unilateral 6-hydroxydopamine-induced lesion duplicated the systemic effects of the drug in a topographical manner. Although there was considerable overlap, it was possible to recognize discrete active zones or “hot-spots” giving rise to prominent sniffing, head movements and contralaterally directed circling, posture and grooming, both in the coronal plane and along the rostro-caudal axis. Two behaviours peculiar to D1 stimulation included contralateral forepaw myoclonus and forepaw nibbling, which paradoxically was directed mainly ipsilaterally. Each of the behavioural elements occurred independently of the others and after an inexplicably long latency. They were inhibited by the D1 antagonist SCH 23390, but not by the D2 blocking drug metoclopramide. Comparable circling responses were evoked by a D2 agonist (lisuride) injected into the neostriatum after a short delay and instantaneously by apomorphine (D1/D2 agonist). Both drug behaviours originated diffusely from all parts of the denervated striatum with no obvious “hot-spots”, except for circling which exhibited a bimodal distribution rostro-caudally. The actions of lisuride were blocked by systemic metoclopramide, but not by SCH 23390, while the actions of apomorphine were inhibited by both antagonists. Topographies of D2 receptor-mediated events were quite different from those encountered for D1 receptor stimulation by SKF 38393, though neither corresponded to the autoradiographic distribution of D1and D2 binding sites in the intact striatum. These results reiterate the importance of D1 receptors in motor control and provide a basis for future investigations of the output pathways subserving D1-mediated behaviours." @default.
• W2012161211 created "2016-06-24" @default.
• W2012161211 creator A5003403640 @default.
• W2012161211 creator A5085423963 @default.
• W2012161211 date "1987-02-01" @default.
• W2012161211 modified "2023-09-23" @default.
• W2012161211 title "Topography of dopamine behaviours mediated by D1 and D2 receptors revealed by intrastriatal injection of SKF 38393, lisuride and apomorphine in rats with a unilateral 6-hydroxydopamine-induced lesion" @default.
• W2012161211 cites W1502396858 @default.
• W2012161211 cites W1514073049 @default.
• W2012161211 cites W1972300208 @default.
• W2012161211 cites W1981988180 @default.
• W2012161211 cites W1984768394 @default.
• W2012161211 cites W1987193373 @default.
• W2012161211 cites W2009579516 @default.
• W2012161211 cites W2017016920 @default.
• W2012161211 cites W2021456013 @default.
• W2012161211 cites W2029667971 @default.
• W2012161211 cites W2030121327 @default.
• W2012161211 cites W2032954959 @default.
• W2012161211 cites W2041817471 @default.
• W2012161211 cites W2045178401 @default.
• W2012161211 cites W2048418281 @default.
• W2012161211 cites W2050709677 @default.
• W2012161211 cites W2051112021 @default.
• W2012161211 cites W2052275359 @default.
• W2012161211 cites W2053496450 @default.
• W2012161211 cites W2054216686 @default.
• W2012161211 cites W2057210658 @default.
• W2012161211 cites W2060790782 @default.
• W2012161211 cites W2061765312 @default.
• W2012161211 cites W2069844118 @default.
• W2012161211 cites W2073881235 @default.
• W2012161211 cites W2077108130 @default.
• W2012161211 cites W2079944200 @default.
• W2012161211 cites W2081385433 @default.
• W2012161211 cites W2084676667 @default.
• W2012161211 cites W2139861698 @default.
• W2012161211 doi "https://doi.org/10.1016/0306-4522(87)90112-6" @default.
• W2012161211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2953990" @default.
• W2012161211 hasPublicationYear "1987" @default.
• W2012161211 type Work @default.
• W2012161211 sameAs 2012161211 @default.
• W2012161211 citedByCount "47" @default.
• W2012161211 countsByYear W20121612112012 @default.
• W2012161211 countsByYear W20121612112015 @default.
• W2012161211 countsByYear W20121612112019 @default.
• W2012161211 crossrefType "journal-article" @default.
• W2012161211 hasAuthorship W2012161211A5003403640 @default.
• W2012161211 hasAuthorship W2012161211A5085423963 @default.
• W2012161211 hasConcept C120069818 @default.
• W2012161211 hasConcept C126322002 @default.
• W2012161211 hasConcept C134018914 @default.
• W2012161211 hasConcept C137183658 @default.
• W2012161211 hasConcept C15744967 @default.
• W2012161211 hasConcept C169760540 @default.
• W2012161211 hasConcept C170493617 @default.
• W2012161211 hasConcept C185592680 @default.
• W2012161211 hasConcept C24998067 @default.
• W2012161211 hasConcept C2777095659 @default.
• W2012161211 hasConcept C2777525119 @default.
• W2012161211 hasConcept C2778125517 @default.
• W2012161211 hasConcept C2778258207 @default.
• W2012161211 hasConcept C2778938600 @default.
• W2012161211 hasConcept C2779917531 @default.
• W2012161211 hasConcept C2780062018 @default.
• W2012161211 hasConcept C44208683 @default.
• W2012161211 hasConcept C513476851 @default.
• W2012161211 hasConcept C71924100 @default.
• W2012161211 hasConcept C86803240 @default.
• W2012161211 hasConceptScore W2012161211C120069818 @default.
• W2012161211 hasConceptScore W2012161211C126322002 @default.
• W2012161211 hasConceptScore W2012161211C134018914 @default.
• W2012161211 hasConceptScore W2012161211C137183658 @default.
• W2012161211 hasConceptScore W2012161211C15744967 @default.
• W2012161211 hasConceptScore W2012161211C169760540 @default.
• W2012161211 hasConceptScore W2012161211C170493617 @default.
• W2012161211 hasConceptScore W2012161211C185592680 @default.
• W2012161211 hasConceptScore W2012161211C24998067 @default.
• W2012161211 hasConceptScore W2012161211C2777095659 @default.
• W2012161211 hasConceptScore W2012161211C2777525119 @default.
• W2012161211 hasConceptScore W2012161211C2778125517 @default.
• W2012161211 hasConceptScore W2012161211C2778258207 @default.
• W2012161211 hasConceptScore W2012161211C2778938600 @default.
• W2012161211 hasConceptScore W2012161211C2779917531 @default.
• W2012161211 hasConceptScore W2012161211C2780062018 @default.
• W2012161211 hasConceptScore W2012161211C44208683 @default.
• W2012161211 hasConceptScore W2012161211C513476851 @default.
• W2012161211 hasConceptScore W2012161211C71924100 @default.
• W2012161211 hasConceptScore W2012161211C86803240 @default.
• W2012161211 hasIssue "2" @default.
• W2012161211 hasLocation W20121612111 @default.
• W2012161211 hasLocation W20121612112 @default.
• W2012161211 hasOpenAccess W2012161211 @default.
• W2012161211 hasPrimaryLocation W20121612111 @default.
• W2012161211 hasRelatedWork W1541356587 @default.
• W2012161211 hasRelatedWork W168655087 @default.
• W2012161211 hasRelatedWork W1980880751 @default.
• W2012161211 hasRelatedWork W2018506937 @default.

• next