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- W2012163650 abstract "Fossilia Mastodi OSSIS, which is a skeletal fossil of a Mastodon, an ancient mammal, has been found to have anxiolytic, sedative and anticonvulsant activities in Oriental medicine. In this study, in vivo characterization of the sedative activities of Fossilia Mastodi OSSIS was performed in order to obtain basic information for the development of a putative natural sedative. The 80% methanol extract of Fossilia Mastodi OSSIS given per os at a dose of 3 g/kg in mice showed anxiolysis, potentiation of pentobarbital sleeping time, reduced locomotor activity, and anticonvulsive activity. Fossilia elicited GABA(A) receptor-mediated anxiolysis. The data obtained suggest that the 80% methanol extract of Fossilia Mastodi OSSIS contains some biologically active principles with sedative activity." @default.
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- W2012163650 date "2006-01-01" @default.
- W2012163650 modified "2023-10-05" @default.
- W2012163650 title "In Vivo Characterization of Sedative Activities of Fossilia Mastodi OSSIS" @default.
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- W2012163650 doi "https://doi.org/10.1248/bpb.29.1414" @default.
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