Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012163997> ?p ?o ?g. }
- W2012163997 endingPage "1240" @default.
- W2012163997 startingPage "1229" @default.
- W2012163997 abstract "The micropig model of chronic alcoholism was used to study the relationship of lipid composition and physical properties in three different tissue membranes from the same animals. Ethanol feeding reduced membrane anisotropy, as measured with the diphenylhexatriene probe, in liver plasma and kidney brush-border membranes but not in jejunal brushborder membranes. Preincubation with ethanol reduced anisotropy in each of the three control membranes, whereas all three membranes from the ethanol-fed group were relatively tolerant to the acute effect of ethanol. In liver and kidney membranes, ethanol feeding increased levels of linoleic (18:2ω6) acid and decreased levels of arachidonic (20:4ω6) and docosahexaenoic (22:6ω3) acids and their specific double-bond positions, consistent with reduced activities of Δ6 and Δ5 fatty acid desaturases. In liver and kidney membranes, anisotropy parameters and the acute effect of ethanol correlated inversely with levels of linoleic acid and directly with levels of arachidonic and docosahexaenoic acids and their specific double bonds. Levels of docosahexaenoic acid correlated with the acute effect of ethanol in all three membranes. Phospholipid fatty acid profiles were similar in jejunal brush-border membranes and terminal bile samples, suggesting that the effects of ethanol on jejunal fatty acids and physical properties are modulated by intraluminal biliary phospholipids. The effect of ethanol on anisotropy could not be attributed to changes in membrane cholesterol/phospholipid ratios. These studies affirm the value of this new animal model of chronic alcoholism and provide comprehensive evidence for the central role of fatty acid desaturation in the membrane-associated effects of ethanol exposure. (HEPATOLOGY 1994;19:1229–1240.)" @default.
- W2012163997 created "2016-06-24" @default.
- W2012163997 creator A5002701077 @default.
- W2012163997 creator A5035940421 @default.
- W2012163997 creator A5041344061 @default.
- W2012163997 creator A5056107787 @default.
- W2012163997 creator A5059222898 @default.
- W2012163997 creator A5088595086 @default.
- W2012163997 creator A5091657759 @default.
- W2012163997 date "1994-05-01" @default.
- W2012163997 modified "2023-09-29" @default.
- W2012163997 title "Effects of ethanol feeding on liver, kidney and jejunal membranes of micropigs" @default.
- W2012163997 cites W1562743220 @default.
- W2012163997 cites W1652494206 @default.
- W2012163997 cites W1906135245 @default.
- W2012163997 cites W1972866768 @default.
- W2012163997 cites W1973846677 @default.
- W2012163997 cites W1974871215 @default.
- W2012163997 cites W1976013737 @default.
- W2012163997 cites W1980387958 @default.
- W2012163997 cites W1980563101 @default.
- W2012163997 cites W1982822810 @default.
- W2012163997 cites W1989923840 @default.
- W2012163997 cites W1991101330 @default.
- W2012163997 cites W1993494285 @default.
- W2012163997 cites W2001992996 @default.
- W2012163997 cites W2006289643 @default.
- W2012163997 cites W2008245705 @default.
- W2012163997 cites W2016411116 @default.
- W2012163997 cites W2020898911 @default.
- W2012163997 cites W2026997553 @default.
- W2012163997 cites W2030362055 @default.
- W2012163997 cites W2034938284 @default.
- W2012163997 cites W2035559527 @default.
- W2012163997 cites W2038359372 @default.
- W2012163997 cites W2041187365 @default.
- W2012163997 cites W2052519074 @default.
- W2012163997 cites W2065114140 @default.
- W2012163997 cites W2078196587 @default.
- W2012163997 cites W2081833254 @default.
- W2012163997 cites W2092396741 @default.
- W2012163997 cites W2093068801 @default.
- W2012163997 cites W2116788602 @default.
- W2012163997 cites W2142015798 @default.
- W2012163997 cites W2166712692 @default.
- W2012163997 cites W2281856017 @default.
- W2012163997 cites W2315929780 @default.
- W2012163997 cites W4301384787 @default.
- W2012163997 cites W4301506578 @default.
- W2012163997 doi "https://doi.org/10.1002/hep.1840190522" @default.
- W2012163997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8175146" @default.
- W2012163997 hasPublicationYear "1994" @default.
- W2012163997 type Work @default.
- W2012163997 sameAs 2012163997 @default.
- W2012163997 citedByCount "10" @default.
- W2012163997 countsByYear W20121639972012 @default.
- W2012163997 countsByYear W20121639972013 @default.
- W2012163997 countsByYear W20121639972018 @default.
- W2012163997 crossrefType "journal-article" @default.
- W2012163997 hasAuthorship W2012163997A5002701077 @default.
- W2012163997 hasAuthorship W2012163997A5035940421 @default.
- W2012163997 hasAuthorship W2012163997A5041344061 @default.
- W2012163997 hasAuthorship W2012163997A5056107787 @default.
- W2012163997 hasAuthorship W2012163997A5059222898 @default.
- W2012163997 hasAuthorship W2012163997A5088595086 @default.
- W2012163997 hasAuthorship W2012163997A5091657759 @default.
- W2012163997 hasBestOaLocation W20121639971 @default.
- W2012163997 hasConcept C126322002 @default.
- W2012163997 hasConcept C134018914 @default.
- W2012163997 hasConcept C181199279 @default.
- W2012163997 hasConcept C185592680 @default.
- W2012163997 hasConcept C19038510 @default.
- W2012163997 hasConcept C2777171753 @default.
- W2012163997 hasConcept C2778078955 @default.
- W2012163997 hasConcept C2778918659 @default.
- W2012163997 hasConcept C2780161600 @default.
- W2012163997 hasConcept C2780809830 @default.
- W2012163997 hasConcept C2781214852 @default.
- W2012163997 hasConcept C41625074 @default.
- W2012163997 hasConcept C543025807 @default.
- W2012163997 hasConcept C55493867 @default.
- W2012163997 hasConcept C71924100 @default.
- W2012163997 hasConcept C86803240 @default.
- W2012163997 hasConceptScore W2012163997C126322002 @default.
- W2012163997 hasConceptScore W2012163997C134018914 @default.
- W2012163997 hasConceptScore W2012163997C181199279 @default.
- W2012163997 hasConceptScore W2012163997C185592680 @default.
- W2012163997 hasConceptScore W2012163997C19038510 @default.
- W2012163997 hasConceptScore W2012163997C2777171753 @default.
- W2012163997 hasConceptScore W2012163997C2778078955 @default.
- W2012163997 hasConceptScore W2012163997C2778918659 @default.
- W2012163997 hasConceptScore W2012163997C2780161600 @default.
- W2012163997 hasConceptScore W2012163997C2780809830 @default.
- W2012163997 hasConceptScore W2012163997C2781214852 @default.
- W2012163997 hasConceptScore W2012163997C41625074 @default.
- W2012163997 hasConceptScore W2012163997C543025807 @default.
- W2012163997 hasConceptScore W2012163997C55493867 @default.
- W2012163997 hasConceptScore W2012163997C71924100 @default.