Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012164530> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2012164530 abstract "Purpose of study Antiretroviral therapy (ART) has been scaled up in resource-limited settings. This study aimed to determine the prevalence of HIV-1 drug resistance-associated mutations (DRAMs) among patients with chronic HIV-1 infection and to compare DRAMs between CRF01_AE and B subtypes. Methods ART-naïve Thai patients who were indicated for ART initiation between 2010 and 2011 were prospectively enrolled. Genotypic assays of reverse transcriptase and protease genes were performed within 4 weeks prior to ART. DRAMs were assessed using International AIDS Society USA 2011 list. Summary of results A total of 330 patients were included. HIV-1 subtypes included CRF01_AE (241, 73.0%), B (79, 23.9%), and others (10, 3.1%). Median (IQR) CD4 was 66 (23–172) cells/mm3 and median (IQR) HIV-1 RNA was 5.2 (4.6–5.8) log copies/mL. The prevalence of patients with≥1 DRAMs to any antiretroviral agents was 17.6%; 17.0% to NNRTIs, 0.6% to NRTIs, and 0.6% to protease inhibitors (PIs). V106I (23, 7.0%), V179D (14, 4.2%), V179T (6, 1.8%), E138A (5, 1.5%), V90I (4, 1.2%), K103N (3, 0.9%), Y181C (3, 0.9%), and P225H (1, 0.3%) were DRAMs to NNRTIs. M184V (1, 0.3%) and T215S (1, 0.3%) were DRAMs to NRTIs. M46L (2, 0.6%) was the only major DRAM to PI. Minor DRAMs to PIs including I13V, M36I, H69K, and L89M were more frequently observed in CRF_01 AE but A71V/T and V77I were more common in subtype B (P < 0.05). By multivariate analysis, the factors ‘HIV-1 subtype B’ and ‘low pretreated CD4 cell count’ were associated with higher rate of DRAMs. Conclusion HIV-1 DRAMs, especially to NNRTIs, is emerging in a middle-income country after a widespread use of NNRTI-based ART. HIV genotypic assay prior to ART initiation in patients with chronic HIV-1 infection should be considered." @default.
- W2012164530 created "2016-06-24" @default.
- W2012164530 creator A5008132510 @default.
- W2012164530 creator A5018752839 @default.
- W2012164530 creator A5035058051 @default.
- W2012164530 creator A5037982588 @default.
- W2012164530 creator A5083235734 @default.
- W2012164530 date "2012-11-11" @default.
- W2012164530 modified "2023-10-05" @default.
- W2012164530 title "HIV-1 drug resistance-associated mutations among antiretroviral-naïve Thai patients with chronic HIV-1 infection" @default.
- W2012164530 doi "https://doi.org/10.7448/ias.15.6.18203" @default.
- W2012164530 hasPublicationYear "2012" @default.
- W2012164530 type Work @default.
- W2012164530 sameAs 2012164530 @default.
- W2012164530 citedByCount "0" @default.
- W2012164530 crossrefType "journal-article" @default.
- W2012164530 hasAuthorship W2012164530A5008132510 @default.
- W2012164530 hasAuthorship W2012164530A5018752839 @default.
- W2012164530 hasAuthorship W2012164530A5035058051 @default.
- W2012164530 hasAuthorship W2012164530A5037982588 @default.
- W2012164530 hasAuthorship W2012164530A5083235734 @default.
- W2012164530 hasBestOaLocation W20121645301 @default.
- W2012164530 hasConcept C104317684 @default.
- W2012164530 hasConcept C114851261 @default.
- W2012164530 hasConcept C126322002 @default.
- W2012164530 hasConcept C135763542 @default.
- W2012164530 hasConcept C142462285 @default.
- W2012164530 hasConcept C156719811 @default.
- W2012164530 hasConcept C159047783 @default.
- W2012164530 hasConcept C181199279 @default.
- W2012164530 hasConcept C182707283 @default.
- W2012164530 hasConcept C2776714187 @default.
- W2012164530 hasConcept C2993143319 @default.
- W2012164530 hasConcept C3013748606 @default.
- W2012164530 hasConcept C49105822 @default.
- W2012164530 hasConcept C55493867 @default.
- W2012164530 hasConcept C71924100 @default.
- W2012164530 hasConcept C86803240 @default.
- W2012164530 hasConcept C89423630 @default.
- W2012164530 hasConceptScore W2012164530C104317684 @default.
- W2012164530 hasConceptScore W2012164530C114851261 @default.
- W2012164530 hasConceptScore W2012164530C126322002 @default.
- W2012164530 hasConceptScore W2012164530C135763542 @default.
- W2012164530 hasConceptScore W2012164530C142462285 @default.
- W2012164530 hasConceptScore W2012164530C156719811 @default.
- W2012164530 hasConceptScore W2012164530C159047783 @default.
- W2012164530 hasConceptScore W2012164530C181199279 @default.
- W2012164530 hasConceptScore W2012164530C182707283 @default.
- W2012164530 hasConceptScore W2012164530C2776714187 @default.
- W2012164530 hasConceptScore W2012164530C2993143319 @default.
- W2012164530 hasConceptScore W2012164530C3013748606 @default.
- W2012164530 hasConceptScore W2012164530C49105822 @default.
- W2012164530 hasConceptScore W2012164530C55493867 @default.
- W2012164530 hasConceptScore W2012164530C71924100 @default.
- W2012164530 hasConceptScore W2012164530C86803240 @default.
- W2012164530 hasConceptScore W2012164530C89423630 @default.
- W2012164530 hasIssue "6(Suppl 4)" @default.
- W2012164530 hasLocation W20121645301 @default.
- W2012164530 hasOpenAccess W2012164530 @default.
- W2012164530 hasPrimaryLocation W20121645301 @default.
- W2012164530 hasRelatedWork W1986861045 @default.
- W2012164530 hasRelatedWork W2001977485 @default.
- W2012164530 hasRelatedWork W2035368109 @default.
- W2012164530 hasRelatedWork W2093785820 @default.
- W2012164530 hasRelatedWork W2114482418 @default.
- W2012164530 hasRelatedWork W2171197540 @default.
- W2012164530 hasRelatedWork W2366933160 @default.
- W2012164530 hasRelatedWork W2378831983 @default.
- W2012164530 hasRelatedWork W2391907079 @default.
- W2012164530 hasRelatedWork W2527791583 @default.
- W2012164530 hasVolume "15" @default.
- W2012164530 isParatext "false" @default.
- W2012164530 isRetracted "false" @default.
- W2012164530 magId "2012164530" @default.
- W2012164530 workType "article" @default.