FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012165639> ?p ?o ?g. }

• W2012165639 endingPage "2660" @default.
• W2012165639 startingPage "2650" @default.
• W2012165639 abstract "Loss of genomic imprinting is involved in a number of developmental abnormalities and cancers. ZAC is an imprinted gene expressed from the paternal allele of chromosome 6q24 within a region known to harbor a tumor suppressor gene for several types of neoplasia. p57 KIP2 ( CDKN1C ) is a maternally expressed gene located on chromosome 11p15.5 which encodes a cyclin-dependent kinase inhibitor that may also act as a tumor suppressor gene. Mutations in ZAC and p57 KIP2 have been implicated in transient neonatal diabetes mellitus (TNDB) and Beckwith–Wiedemann syndrome, respectively. Patients with these diseases share many characteristics. Here we show that mouse Zac1 and p57 Kip2 have a strikingly similar expression pattern. ZAC, a sequence-specific DNA-binding protein, binds within the CpG island of LIT1 (KCNQ1OT1) , a paternally expressed, anti-sense RNA thought to negatively regulate p57 KIP2 in cis . ZAC induces LIT1 transcription in a methylation-dependent manner. Our data suggest that ZAC may regulate p57 KIP2 through LIT1 , forming part of a novel signaling pathway regulating cell growth. Mutations in ZAC may, therefore, contribute to Beckwith–Wiedemann syndrome. Furthermore, we find changes in DNA methylation at the LIT1 putative imprinting control region in two patients with TNDB." @default.
• W2012165639 created "2016-06-24" @default.
• W2012165639 creator A5014344416 @default.
• W2012165639 creator A5018042617 @default.
• W2012165639 creator A5025083311 @default.
• W2012165639 creator A5035616439 @default.
• W2012165639 creator A5049283637 @default.
• W2012165639 creator A5053209113 @default.
• W2012165639 creator A5072055558 @default.
• W2012165639 creator A5072446521 @default.
• W2012165639 creator A5089438363 @default.
• W2012165639 creator A5090025641 @default.
• W2012165639 date "2005-04-28" @default.
• W2012165639 modified "2023-09-27" @default.
• W2012165639 title "ZAC, LIT1 (KCNQ1OT1) and p57KIP2 (CDKN1C) are in an imprinted gene network that may play a role in Beckwith-Wiedemann syndrome" @default.
• W2012165639 cites W1542932778 @default.
• W2012165639 cites W1557960509 @default.
• W2012165639 cites W1564135407 @default.
• W2012165639 cites W1791188340 @default.
• W2012165639 cites W1843486138 @default.
• W2012165639 cites W1963807858 @default.
• W2012165639 cites W1964789204 @default.
• W2012165639 cites W1964854482 @default.
• W2012165639 cites W1968605379 @default.
• W2012165639 cites W1973908282 @default.
• W2012165639 cites W1976208541 @default.
• W2012165639 cites W1978386737 @default.
• W2012165639 cites W1985064409 @default.
• W2012165639 cites W1990423443 @default.
• W2012165639 cites W1997820996 @default.
• W2012165639 cites W2000134487 @default.
• W2012165639 cites W2001623646 @default.
• W2012165639 cites W2003569992 @default.
• W2012165639 cites W2016730049 @default.
• W2012165639 cites W2028702466 @default.
• W2012165639 cites W2030163419 @default.
• W2012165639 cites W2034403814 @default.
• W2012165639 cites W2040693133 @default.
• W2012165639 cites W2042846772 @default.
• W2012165639 cites W2044929234 @default.
• W2012165639 cites W2046241907 @default.
• W2012165639 cites W2046790914 @default.
• W2012165639 cites W2055085859 @default.
• W2012165639 cites W2060251266 @default.
• W2012165639 cites W2075805514 @default.
• W2012165639 cites W2075980717 @default.
• W2012165639 cites W2083627679 @default.
• W2012165639 cites W2098028662 @default.
• W2012165639 cites W2114669518 @default.
• W2012165639 cites W2115023351 @default.
• W2012165639 cites W2117538040 @default.
• W2012165639 cites W2122022514 @default.
• W2012165639 cites W2124600612 @default.
• W2012165639 cites W2125537684 @default.
• W2012165639 cites W2125811643 @default.
• W2012165639 cites W2129115383 @default.
• W2012165639 cites W2132970617 @default.
• W2012165639 cites W2133585570 @default.
• W2012165639 cites W2148532920 @default.
• W2012165639 cites W2158115867 @default.
• W2012165639 cites W2160251268 @default.
• W2012165639 cites W2160842824 @default.
• W2012165639 cites W2171322222 @default.
• W2012165639 doi "https://doi.org/10.1093/nar/gki555" @default.
• W2012165639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1097765" @default.
• W2012165639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15888726" @default.
• W2012165639 hasPublicationYear "2005" @default.
• W2012165639 type Work @default.
• W2012165639 sameAs 2012165639 @default.
• W2012165639 citedByCount "131" @default.
• W2012165639 countsByYear W20121656392012 @default.
• W2012165639 countsByYear W20121656392013 @default.
• W2012165639 countsByYear W20121656392014 @default.
• W2012165639 countsByYear W20121656392015 @default.
• W2012165639 countsByYear W20121656392016 @default.
• W2012165639 countsByYear W20121656392017 @default.
• W2012165639 countsByYear W20121656392018 @default.
• W2012165639 countsByYear W20121656392019 @default.
• W2012165639 countsByYear W20121656392020 @default.
• W2012165639 countsByYear W20121656392021 @default.
• W2012165639 countsByYear W20121656392022 @default.
• W2012165639 crossrefType "journal-article" @default.
• W2012165639 hasAuthorship W2012165639A5014344416 @default.
• W2012165639 hasAuthorship W2012165639A5018042617 @default.
• W2012165639 hasAuthorship W2012165639A5025083311 @default.
• W2012165639 hasAuthorship W2012165639A5035616439 @default.
• W2012165639 hasAuthorship W2012165639A5049283637 @default.
• W2012165639 hasAuthorship W2012165639A5053209113 @default.
• W2012165639 hasAuthorship W2012165639A5072055558 @default.
• W2012165639 hasAuthorship W2012165639A5072446521 @default.
• W2012165639 hasAuthorship W2012165639A5089438363 @default.
• W2012165639 hasAuthorship W2012165639A5090025641 @default.
• W2012165639 hasBestOaLocation W20121656391 @default.
• W2012165639 hasConcept C104317684 @default.
• W2012165639 hasConcept C140173407 @default.
• W2012165639 hasConcept C150194340 @default.
• W2012165639 hasConcept C190727270 @default.
• W2012165639 hasConcept C201492766 @default.

• next