Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012168050> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2012168050 endingPage "80" @default.
- W2012168050 startingPage "77" @default.
- W2012168050 abstract "The neuropathology of Parkinson's disease (PD) involves a reduction of endogenous antioxidant enzyme systems, heightened oxidative stress and mitochondrial aberrations in the region of the substantia nigra. Similarly, neurotoxins commonly used to investigate PD pathology include 6-hydroxydopamine (6-OHDA), a powerful hydrogen peroxide (H(2)0(2)) pro-oxidant and 1-methyl-4-phenylpyridinium ion (MPP+), a mitochondrial complex I inhibitor that exerts detrimental effects on cellular energy production. Pyruvic acid is a neuronal metabolic energy fuel that can also rapidly undergo decarboxylation to diffuse H(2)0(2) into H(2)0. In this study, we investigated the effect of pyruvic acid against 6-OHDA, MPP+ and H(2)0(2) toxicity in murine brain neuroblastoma cells. The results obtained indicated that the toxicity of 6-OHDA was inversely related to the autoxidative formation of H(2)0(2). Pyruvic acid exhibited powerful non-enzymatic stoichiometric H(2)0(2) trapping properties, and protected against both 6-OHDA and H(2)0(2) toxicity. While both sodium pyruvate and pyruvate were highly protective against oxidative stress, pyruvate in its free acid form only was protective against MPP+, indicating a requirement for effective transport in order to fuel glycolysis. The protective properties of glucose were compared to pyruvic acid, and the data indicated that glucose did not exhibit antioxidant properties and was effective in blocking MPP+, but not 6-OHDA or H(2)0(2) toxicity. On the other hand, pyruvic acid was protective against all three toxins, and unlike glucose, completely blocked MPP+ toxicity in a combination insult model with up to 500 microM of H(2)0(2). Moreover, the data obtained indicate that pyruvic acid exerts powerful neuroprotective properties by providing simultaneous resistance to oxidative stress and mitochondrial insult. These protective effects are the result of a unique dual property of pyruvic acid with concurrent ability to serve as an effective neuronal energy substrate for glycolysis and to act as an exceptionally powerful antioxidant." @default.
- W2012168050 created "2016-06-24" @default.
- W2012168050 creator A5035760747 @default.
- W2012168050 creator A5056430801 @default.
- W2012168050 date "2003-02-01" @default.
- W2012168050 modified "2023-10-10" @default.
- W2012168050 title "Pyruvic acid cytoprotection against 1-methyl-4-phenylpyridinium, 6-hydroxydopamine and hydrogen peroxide toxicities in vitro" @default.
- W2012168050 cites W1504584187 @default.
- W2012168050 cites W1693234450 @default.
- W2012168050 cites W1775749144 @default.
- W2012168050 cites W1989352200 @default.
- W2012168050 cites W1991506982 @default.
- W2012168050 cites W2030362088 @default.
- W2012168050 cites W2037288337 @default.
- W2012168050 cites W2045147785 @default.
- W2012168050 cites W2046807021 @default.
- W2012168050 cites W2049805159 @default.
- W2012168050 cites W2054701937 @default.
- W2012168050 cites W2057323378 @default.
- W2012168050 cites W2075197040 @default.
- W2012168050 cites W2079231229 @default.
- W2012168050 cites W2122827315 @default.
- W2012168050 cites W2156691850 @default.
- W2012168050 cites W2168380686 @default.
- W2012168050 cites W2177092266 @default.
- W2012168050 cites W2330311660 @default.
- W2012168050 doi "https://doi.org/10.1016/s0304-3940(02)01327-7" @default.
- W2012168050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12527392" @default.
- W2012168050 hasPublicationYear "2003" @default.
- W2012168050 type Work @default.
- W2012168050 sameAs 2012168050 @default.
- W2012168050 citedByCount "44" @default.
- W2012168050 countsByYear W20121680502012 @default.
- W2012168050 countsByYear W20121680502013 @default.
- W2012168050 countsByYear W20121680502014 @default.
- W2012168050 countsByYear W20121680502015 @default.
- W2012168050 countsByYear W20121680502016 @default.
- W2012168050 countsByYear W20121680502017 @default.
- W2012168050 countsByYear W20121680502018 @default.
- W2012168050 countsByYear W20121680502019 @default.
- W2012168050 countsByYear W20121680502020 @default.
- W2012168050 countsByYear W20121680502022 @default.
- W2012168050 crossrefType "journal-article" @default.
- W2012168050 hasAuthorship W2012168050A5035760747 @default.
- W2012168050 hasAuthorship W2012168050A5056430801 @default.
- W2012168050 hasConcept C178790620 @default.
- W2012168050 hasConcept C185592680 @default.
- W2012168050 hasConcept C2776151105 @default.
- W2012168050 hasConcept C2777179333 @default.
- W2012168050 hasConcept C2777324261 @default.
- W2012168050 hasConcept C2778004101 @default.
- W2012168050 hasConcept C2780358027 @default.
- W2012168050 hasConcept C29730261 @default.
- W2012168050 hasConcept C533411734 @default.
- W2012168050 hasConcept C55493867 @default.
- W2012168050 hasConcept C86803240 @default.
- W2012168050 hasConcept C98274493 @default.
- W2012168050 hasConceptScore W2012168050C178790620 @default.
- W2012168050 hasConceptScore W2012168050C185592680 @default.
- W2012168050 hasConceptScore W2012168050C2776151105 @default.
- W2012168050 hasConceptScore W2012168050C2777179333 @default.
- W2012168050 hasConceptScore W2012168050C2777324261 @default.
- W2012168050 hasConceptScore W2012168050C2778004101 @default.
- W2012168050 hasConceptScore W2012168050C2780358027 @default.
- W2012168050 hasConceptScore W2012168050C29730261 @default.
- W2012168050 hasConceptScore W2012168050C533411734 @default.
- W2012168050 hasConceptScore W2012168050C55493867 @default.
- W2012168050 hasConceptScore W2012168050C86803240 @default.
- W2012168050 hasConceptScore W2012168050C98274493 @default.
- W2012168050 hasIssue "2" @default.
- W2012168050 hasLocation W20121680501 @default.
- W2012168050 hasLocation W20121680502 @default.
- W2012168050 hasOpenAccess W2012168050 @default.
- W2012168050 hasPrimaryLocation W20121680501 @default.
- W2012168050 hasRelatedWork W1968618667 @default.
- W2012168050 hasRelatedWork W1974402744 @default.
- W2012168050 hasRelatedWork W2012168050 @default.
- W2012168050 hasRelatedWork W2024506433 @default.
- W2012168050 hasRelatedWork W2038028992 @default.
- W2012168050 hasRelatedWork W2051628950 @default.
- W2012168050 hasRelatedWork W2135757454 @default.
- W2012168050 hasRelatedWork W2334297553 @default.
- W2012168050 hasRelatedWork W2413131738 @default.
- W2012168050 hasRelatedWork W2419022866 @default.
- W2012168050 hasVolume "337" @default.
- W2012168050 isParatext "false" @default.
- W2012168050 isRetracted "false" @default.
- W2012168050 magId "2012168050" @default.
- W2012168050 workType "article" @default.