FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012169024> ?p ?o ?g. }

• W2012169024 endingPage "6742" @default.
• W2012169024 startingPage "6733" @default.
• W2012169024 abstract "Abstract T-cell alloreactivity directed against non–self-HLA molecules has been assumed to be less peptide specific than conventional T-cell reactivity. A large variation in degree of peptide specificity has previously been reported, including single peptide specificity, polyspecificity, and peptide degeneracy. Peptide polyspecificity was illustrated using synthetic peptide-loaded target cells, but in the absence of confirmation against endogenously processed peptides this may represent low-avidity T-cell reactivity. Peptide degeneracy was concluded based on recognition of Ag-processing defective cells. In addition, because most investigated alloreactive T cells were in vitro activated and expanded, the previously determined specificities may have not been representative for alloreactivity in vivo. To study the biologically relevant peptide specificity and avidity of alloreactivity, we investigated the degree of peptide specificity of 50 different allo-HLA–reactive T-cell clones which were activated and expanded in vivo during GVHD. All but one of the alloreactive T-cell clones, including those reactive against Ag-processing defective T2 cells, recognized a single peptide allo-HLA complex, unique for each clone. Down-regulation of the expression of the recognized Ags using silencing shRNAs confirmed single peptide specificity. Based on these results, we conclude that biologically relevant alloreactivity selected during in vivo immune response is peptide specific." @default.
• W2012169024 created "2016-06-24" @default.
• W2012169024 creator A5014860636 @default.
• W2012169024 creator A5021731198 @default.
• W2012169024 creator A5023498056 @default.
• W2012169024 creator A5023680306 @default.
• W2012169024 creator A5033858885 @default.
• W2012169024 creator A5042295492 @default.
• W2012169024 creator A5046636501 @default.
• W2012169024 creator A5058862472 @default.
• W2012169024 creator A5072565167 @default.
• W2012169024 creator A5083956067 @default.
• W2012169024 date "2011-12-22" @default.
• W2012169024 modified "2023-10-01" @default.
• W2012169024 title "Allo-HLA–reactive T cells inducing graft-versus-host disease are single peptide specific" @default.
• W2012169024 cites W1552500687 @default.
• W2012169024 cites W1552827176 @default.
• W2012169024 cites W1556309562 @default.
• W2012169024 cites W1556986209 @default.
• W2012169024 cites W1970688528 @default.
• W2012169024 cites W1983763785 @default.
• W2012169024 cites W1986354535 @default.
• W2012169024 cites W1993446370 @default.
• W2012169024 cites W1997182324 @default.
• W2012169024 cites W2002113738 @default.
• W2012169024 cites W2026566525 @default.
• W2012169024 cites W2034712661 @default.
• W2012169024 cites W2044825285 @default.
• W2012169024 cites W2051949323 @default.
• W2012169024 cites W2054394975 @default.
• W2012169024 cites W2055579456 @default.
• W2012169024 cites W2075297343 @default.
• W2012169024 cites W2076125315 @default.
• W2012169024 cites W2077215890 @default.
• W2012169024 cites W2079683161 @default.
• W2012169024 cites W2082509164 @default.
• W2012169024 cites W2097940672 @default.
• W2012169024 cites W2105996171 @default.
• W2012169024 cites W2114675843 @default.
• W2012169024 cites W2114984025 @default.
• W2012169024 cites W2121723772 @default.
• W2012169024 cites W2133431461 @default.
• W2012169024 cites W2146074801 @default.
• W2012169024 cites W2150178690 @default.
• W2012169024 cites W2152544848 @default.
• W2012169024 cites W2153697534 @default.
• W2012169024 cites W2158076252 @default.
• W2012169024 doi "https://doi.org/10.1182/blood-2011-05-354787" @default.
• W2012169024 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21972290" @default.
• W2012169024 hasPublicationYear "2011" @default.
• W2012169024 type Work @default.
• W2012169024 sameAs 2012169024 @default.
• W2012169024 citedByCount "56" @default.
• W2012169024 countsByYear W20121690242012 @default.
• W2012169024 countsByYear W20121690242013 @default.
• W2012169024 countsByYear W20121690242014 @default.
• W2012169024 countsByYear W20121690242015 @default.
• W2012169024 countsByYear W20121690242016 @default.
• W2012169024 countsByYear W20121690242017 @default.
• W2012169024 countsByYear W20121690242018 @default.
• W2012169024 countsByYear W20121690242019 @default.
• W2012169024 countsByYear W20121690242020 @default.
• W2012169024 countsByYear W20121690242021 @default.
• W2012169024 countsByYear W20121690242022 @default.
• W2012169024 countsByYear W20121690242023 @default.
• W2012169024 crossrefType "journal-article" @default.
• W2012169024 hasAuthorship W2012169024A5014860636 @default.
• W2012169024 hasAuthorship W2012169024A5021731198 @default.
• W2012169024 hasAuthorship W2012169024A5023498056 @default.
• W2012169024 hasAuthorship W2012169024A5023680306 @default.
• W2012169024 hasAuthorship W2012169024A5033858885 @default.
• W2012169024 hasAuthorship W2012169024A5042295492 @default.
• W2012169024 hasAuthorship W2012169024A5046636501 @default.
• W2012169024 hasAuthorship W2012169024A5058862472 @default.
• W2012169024 hasAuthorship W2012169024A5072565167 @default.
• W2012169024 hasAuthorship W2012169024A5083956067 @default.
• W2012169024 hasBestOaLocation W20121690241 @default.
• W2012169024 hasConcept C147483822 @default.
• W2012169024 hasConcept C153911025 @default.
• W2012169024 hasConcept C179223381 @default.
• W2012169024 hasConcept C185592680 @default.
• W2012169024 hasConcept C188280979 @default.
• W2012169024 hasConcept C203014093 @default.
• W2012169024 hasConcept C207001950 @default.
• W2012169024 hasConcept C2776090121 @default.
• W2012169024 hasConcept C2777119779 @default.
• W2012169024 hasConcept C2779281246 @default.
• W2012169024 hasConcept C54355233 @default.
• W2012169024 hasConcept C55493867 @default.
• W2012169024 hasConcept C86803240 @default.
• W2012169024 hasConcept C8891405 @default.
• W2012169024 hasConceptScore W2012169024C147483822 @default.
• W2012169024 hasConceptScore W2012169024C153911025 @default.
• W2012169024 hasConceptScore W2012169024C179223381 @default.
• W2012169024 hasConceptScore W2012169024C185592680 @default.
• W2012169024 hasConceptScore W2012169024C188280979 @default.
• W2012169024 hasConceptScore W2012169024C203014093 @default.
• W2012169024 hasConceptScore W2012169024C207001950 @default.

• next