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- W2012169516 abstract "Abstract The preparation is described of three types of liposomes containing biologically active human fibroblast interferon. Depending on the preparative method, up to 50% of the initial interferon activity could be recovered associated with the liposomes, 15–30% being entrapped into the aqueous space of the vesicles. Encapsulation into negatively charged liposomes is dependent on the acidic phospholipid content; liposomes bearing a net positive charge could capture more interferon than those with a negative charge but were toxic to the target cells. Expression of biological activity of liposomes encapsulated interferon was demonstrated by their antiviral activity and their ability to prime interferon induction." @default.
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- W2012169516 date "1982-07-01" @default.
- W2012169516 modified "2023-09-26" @default.
- W2012169516 title "Encapsulation of human fibroblast interferon activity in liposomes" @default.
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- W2012169516 doi "https://doi.org/10.1016/0006-291x(82)91680-1" @default.
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