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- W2012170367 abstract "Generally lympho-plasmacytic malignancies are of monoclonal origin in that neoplastic B cells produce immunoglobulin (Ig) composed of a single class of heavy and light chains. Thus the presence of more than one monotypic Ig on the surface and in the cytoplasm of the neoplastic cells of a patient constitutes an uncommon event. We are presenting an 11 year old boy with acute lymphoblastic leukemia of the rare B-cell type in which the same neoplastic cells produced both κ and τ light chains without any heavy chains as demonstrated by double immunofluorescence. There was evidence of secretion of both κ and τ light chains in cultures of the leukemic cells. Secretion of both light chains into the blood was also demonstrated at postmortem examination. Although the production of more than a single class of Ig has been known to occur in rare cases of multiple myeloma and Waldenstrom's macroglobulinemia, such an event has not been reported in patients with leukemia or lymphoma." @default.
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- W2012170367 date "1981-04-01" @default.
- W2012170367 modified "2023-09-25" @default.
- W2012170367 title "904 DOUBLE LIGHT CHAIN PRODUCTION BY LEUKEMIC CELLS OF COMMON CLONAL ORIGIN" @default.
- W2012170367 doi "https://doi.org/10.1203/00006450-198104001-00929" @default.
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