Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012170675> ?p ?o ?g. }
- W2012170675 endingPage "424" @default.
- W2012170675 startingPage "415" @default.
- W2012170675 abstract "•ZnT8, the product of the SLC30A8 gene, mediates zinc uptake into insulin secretory granules within pancreatic islet β cells. •Polymorphisms in SLC30A8 are associated with decreased risk for T2D in humans. •Slc30a8 knockout mice show a marked reduction in β cell zinc content but a mild metabolic phenotype. •Potential mechanisms linking polymorphisms in SLC30A8 with changed risk for T2D include reduced insulin secretion, increased insulin clearance, and greater sensitivity to reactive oxygen species. Human pancreatic β cells have exceptionally high zinc content. In β cells the highest zinc concentration is in insulin secretory granules, from which it is cosecreted with the hormone. Uptake of zinc into secretory granules is mainly mediated by zinc transporter 8 (ZnT8), the product of the SLC30A8 [solute carrier family 30 (zinc transporter), member 8] gene. The minor alleles of several single-nucleotide polymorphisms (SNPs) in SLC30A8 are associated with decreased risk of type 2 diabetes (T2D), but the precise mechanisms underlying the protective effects remain uncertain. In this article we review current knowledge of the role of ZnT8 in maintaining zinc homeostasis in β cells, its role in glucose metabolism based on knockout mouse studies, and current theories regarding the link between ZnT8 function and T2D. Human pancreatic β cells have exceptionally high zinc content. In β cells the highest zinc concentration is in insulin secretory granules, from which it is cosecreted with the hormone. Uptake of zinc into secretory granules is mainly mediated by zinc transporter 8 (ZnT8), the product of the SLC30A8 [solute carrier family 30 (zinc transporter), member 8] gene. The minor alleles of several single-nucleotide polymorphisms (SNPs) in SLC30A8 are associated with decreased risk of type 2 diabetes (T2D), but the precise mechanisms underlying the protective effects remain uncertain. In this article we review current knowledge of the role of ZnT8 in maintaining zinc homeostasis in β cells, its role in glucose metabolism based on knockout mouse studies, and current theories regarding the link between ZnT8 function and T2D." @default.
- W2012170675 created "2016-06-24" @default.
- W2012170675 creator A5054029531 @default.
- W2012170675 creator A5069819556 @default.
- W2012170675 creator A5081946880 @default.
- W2012170675 date "2014-08-01" @default.
- W2012170675 modified "2023-09-30" @default.
- W2012170675 title "Zinc transporter 8 (ZnT8) and β cell function" @default.
- W2012170675 cites W123484086 @default.
- W2012170675 cites W1490445974 @default.
- W2012170675 cites W1905913105 @default.
- W2012170675 cites W1944558458 @default.
- W2012170675 cites W1964123359 @default.
- W2012170675 cites W1964738953 @default.
- W2012170675 cites W1965490690 @default.
- W2012170675 cites W1965863026 @default.
- W2012170675 cites W1968355797 @default.
- W2012170675 cites W1970611977 @default.
- W2012170675 cites W1977697783 @default.
- W2012170675 cites W1978371202 @default.
- W2012170675 cites W1983092821 @default.
- W2012170675 cites W1985431145 @default.
- W2012170675 cites W1987002804 @default.
- W2012170675 cites W1989257844 @default.
- W2012170675 cites W1990332932 @default.
- W2012170675 cites W1991788296 @default.
- W2012170675 cites W1992231742 @default.
- W2012170675 cites W1996018366 @default.
- W2012170675 cites W1996156357 @default.
- W2012170675 cites W1997365082 @default.
- W2012170675 cites W1998423449 @default.
- W2012170675 cites W2003218731 @default.
- W2012170675 cites W2003822998 @default.
- W2012170675 cites W2010174774 @default.
- W2012170675 cites W2010944337 @default.
- W2012170675 cites W2011183592 @default.
- W2012170675 cites W2011360674 @default.
- W2012170675 cites W2012519624 @default.
- W2012170675 cites W2013949233 @default.
- W2012170675 cites W2015180293 @default.
- W2012170675 cites W2017774881 @default.
- W2012170675 cites W2019028906 @default.
- W2012170675 cites W2019236422 @default.
- W2012170675 cites W2020542551 @default.
- W2012170675 cites W2021209937 @default.
- W2012170675 cites W2021490947 @default.
- W2012170675 cites W2025143098 @default.
- W2012170675 cites W2025611142 @default.
- W2012170675 cites W2031661176 @default.
- W2012170675 cites W2032734258 @default.
- W2012170675 cites W2034811041 @default.
- W2012170675 cites W2038079486 @default.
- W2012170675 cites W2042685738 @default.
- W2012170675 cites W2042995702 @default.
- W2012170675 cites W2044274518 @default.
- W2012170675 cites W2048755332 @default.
- W2012170675 cites W2054438230 @default.
- W2012170675 cites W2059643898 @default.
- W2012170675 cites W2066752848 @default.
- W2012170675 cites W2072952102 @default.
- W2012170675 cites W2078908895 @default.
- W2012170675 cites W2082122713 @default.
- W2012170675 cites W2083871183 @default.
- W2012170675 cites W2084020057 @default.
- W2012170675 cites W2086894303 @default.
- W2012170675 cites W2087254300 @default.
- W2012170675 cites W2088681775 @default.
- W2012170675 cites W2088805278 @default.
- W2012170675 cites W2088878246 @default.
- W2012170675 cites W2092014335 @default.
- W2012170675 cites W2093090129 @default.
- W2012170675 cites W2093900806 @default.
- W2012170675 cites W2094943786 @default.
- W2012170675 cites W2097259690 @default.
- W2012170675 cites W2097951289 @default.
- W2012170675 cites W2104662960 @default.
- W2012170675 cites W2105051532 @default.
- W2012170675 cites W2108481722 @default.
- W2012170675 cites W2108493196 @default.
- W2012170675 cites W2114055879 @default.
- W2012170675 cites W2116394634 @default.
- W2012170675 cites W2117706536 @default.
- W2012170675 cites W2120302366 @default.
- W2012170675 cites W2129406210 @default.
- W2012170675 cites W2130595746 @default.
- W2012170675 cites W2132484969 @default.
- W2012170675 cites W2132636509 @default.
- W2012170675 cites W2136454890 @default.
- W2012170675 cites W2137204463 @default.
- W2012170675 cites W2137761662 @default.
- W2012170675 cites W2141082893 @default.
- W2012170675 cites W2141642891 @default.
- W2012170675 cites W2144576542 @default.
- W2012170675 cites W2147519918 @default.
- W2012170675 cites W2148175667 @default.
- W2012170675 cites W2148468014 @default.
- W2012170675 cites W2151600164 @default.
- W2012170675 cites W2152089260 @default.