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• W2012170788 abstract "Using a binding site selection procedure, we have found that sequence-specific DNA-binding by the mouse c-myb protein involves recognition of nucleotides outside of the previously identified hexanucleotide motif. Ollgonucleotides containing a random nucleotide core were immunoprecipitated in association with c-Myb, amplified by the Polymerase Chain Reaction and cloned in plasmids prior to sequencing. By alignment of sequences it was apparent that additional preferences existed at each of three bases immediately 5' of the hexanucleotide consensus, allowing an extension of the preferred binding site to YGRCVGTTR. The contributions of these 5' nucleotides to binding affinity was established in bandshift analyses with oligonucleotides containing single base substitutions; in particular, it was found that replacement of the preferred guanine at position - 2 with any other base greatly reduced c-Myb binding. We found that the protein encoded by the related B-myb gene bound the preferred c-Myb site with similar affinity; however, B-Myb and c-Myb showed distinct preferences for the identity of the nucleotide at position -1 relative to the hexanucleotide consensus. This study demonstrates that the c-Myb DNA-binding site is more extensive than recognised hitherto and points to similar but distinct nucleotide preferences in recognition of DNA by related Myb proteins." @default.
• W2012170788 created "2016-06-24" @default.
• W2012170788 creator A5033335781 @default.
• W2012170788 creator A5066183698 @default.
• W2012170788 date "1991-01-01" @default.
• W2012170788 modified "2023-09-29" @default.
• W2012170788 title "Nucleotide preferences in sequence-specific recognition of DNA by c-<i>myb</i>protein" @default.
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• W2012170788 doi "https://doi.org/10.1093/nar/19.14.3913" @default.
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