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• W2012171119 endingPage "350" @default.
• W2012171119 startingPage "347" @default.
• W2012171119 abstract "1 The 8–32 fragment of salmon calcitonin ((8–32) sCT) has been proposed as a highly selective amylin receptor antagonist. 2 In the present study, we have studied the influence of (8–32) sCT on the inhibitory effect of both amylin and its structural congener, calcitonin gene-related peptide (CGRP), on insulin secretion in the rat perfused pancreas. 3 Both amylin and CGRP, at 75 pM, clearly inhibited glucose-induced insulin release (by 80% and by 70%, respectively). Simultaneous infusion of 10 μm (8–32) sCT reversed the inhibitory effect of amylin (by 80%; P<0.05 vs. amylin experiments) but did not significantly affect the inhibition of glucose-induced insulin output elicited by CGRP. Furthermore, at the same concentration (10 μm), (8–32) sCT alone potentiated the insulin response to 7 mM glucose (2.5 fold; P<0.05) whilst it did not affect glucagon or somatostatin secretion. 4 The observation that infusion of an amylin antagonist into the rat pancreas potentiates the insulin response to glucose, favours the concept of endogenous amylin as an inhibitor of insulin release. 5 Finally, as an amylin antagonist at the level of the β-cell, (8–32) sCT might be considered of potential interest in experimental and clinical pharmacology." @default.
• W2012171119 created "2016-06-24" @default.
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• W2012171119 date "1996-01-01" @default.
• W2012171119 modified "2023-10-15" @default.
• W2012171119 title "Effect of (8-32) salmon calcitonin, an amylin antagonist, on insulin, glucagon and somatostatin release: study in the perfused pancreas of the rat" @default.
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• W2012171119 doi "https://doi.org/10.1111/j.1476-5381.1996.tb15197.x" @default.
• W2012171119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1909271" @default.
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