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• W2012172023 abstract "The folic acid antagonist, 4-aminopteroyl glutamic acid (aminopterin), is a potent inhibitor of growth and of connective tissue proliferation. The present study indicates that the suppressive effects of aminopterin on epithelial structures are more striking than on connective tissue, as revealed by observation of interference with wound healing and epithelization, atrophy and ulceration of mucosa, alopecia, and prompt suppressive effects in such dermatologic disorders as psoriasis and chronic indurative dermatoses. Aminopterin was administered orally in daily doses of 1.5 to 2.0 mg. to thirteen patients with psoriasis (of whom six had associated arthritis) and to five patients with chronic indurative dermatoses. The latter included one patient with chronic atopic eczematoid dermatitis with associated asthma, one with chronic eczematoid seborrheic dermatitis, one with chronic discoid lupus erythematosus involving the face, and two with scleroderma. In all patients there were remissions in cutaneous lesions, which appeared most commonly between the 5th and 10th day of aminopterin therapy. Treatment was interrupted in most patients after an initial course of 14 to 28 mg. because of the regular occurrence of shallow ulceration of the buccal mucosa and frequent development of abdominal cramps. Remissions persisted for periods ranging from two weeks to several months, after which lesions returned which responded to further courses of aminopterin. The therapeutic response was more complete in the seven patients with psoriatic arthritis than in in six subjects with uncomplicated psoriasis. In four patients with psoriatic arthritis in whom the responses to aminopterin and cortisone were compared, arthritic manifestations were considerably more relieved by cortisone, but improvement in psoriasis was consistently more complete and more sustained with aminopterin. No evidence of a summative effect of cortisone and aminopterin on psoriasis was observed when the two were employed concomitantly, although amelioration of arthritic symptoms was more complete than when cortisone was given alone. Topical application of aminopterin in a 1% ointment was found to be ineffective. Aminopterin is a toxic drug, and its administration must be carefully supervised. The citrovorum factor has proved useful in overcoming aminopterin toxicity but interferes with its therapeutic effects. It is suggested that aminopterin may prove useful in other dermatologic disorders and in cutaneous manifestations of some systemic diseases which, in certain instances, have been temporarily benefited by cortisone." @default.
• W2012172023 created "2016-06-24" @default.
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• W2012172023 date "1951-12-01" @default.
• W2012172023 modified "2023-10-14" @default.
• W2012172023 title "EFFECT OF AMINOPTERIN ON EPITHELIAL TISSUES" @default.
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• W2012172023 doi "https://doi.org/10.1001/archderm.1951.01570120023004" @default.
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