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- W2012173029 abstract "Pathological, genetic and epidemiological studies support the opinion that inflammatory mechanisms are involved in the pathogenesis of Alzheimer's disease (AD). Recent pathological and neuroradiological (PET) data show that activation of microglia is an early pathogenic event that precedes the process of severe neuropil destruction in AD brains. In this paper we review the evidence that inflammatory mediators can play a pathogenic role in some behavioural disorders frequently encountered during the clinical course in AD patients. Motivational disturbances are the most striking of the depressive symptoms in AD and can be present in a preclinical stage of the disease. Experimental animal studies and clinical trials in humans have shown that cytokines can induce similar symptoms which were described as ‘sickness behaviour’ or ‘depressive-like’ state. Delirious states are frequently observed in more advanced stages of dementia. Delirium is generally considered the result of an imbalance in neurotransmitter systems with severe deficits of the cholinergic systems. Animal studies show that pro-inflammatory cytokines, such as interleukin-1, induce a reduced activity of the cholinergic system. In AD, the release of cytokines would exacerbate any already existing disturbances in the cholinergic neurotransmission. This could explain the susceptibility of demented patients to delirium provoked by a wide variety of trivial incidents that are accompanied by an acute phase response. The data reviewed in this paper suggest that it could be worthwhile employing a neuroimmunological approach to study at molecular level the pathogenesis of a broad spectrum of behavioural disturbances common in the clinical course of AD patients." @default.
- W2012173029 created "2016-06-24" @default.
- W2012173029 creator A5000551744 @default.
- W2012173029 creator A5018211312 @default.
- W2012173029 creator A5025338782 @default.
- W2012173029 creator A5082860350 @default.
- W2012173029 date "2002-09-01" @default.
- W2012173029 modified "2023-10-12" @default.
- W2012173029 title "Immunological mechanisms and the spectrum of psychiatric syndromes in Alzheimer's disease" @default.
- W2012173029 cites W1507138941 @default.
- W2012173029 cites W1652739389 @default.
- W2012173029 cites W1693283493 @default.
- W2012173029 cites W1783512343 @default.
- W2012173029 cites W1893620705 @default.
- W2012173029 cites W1910065219 @default.
- W2012173029 cites W1933795947 @default.
- W2012173029 cites W1965762855 @default.
- W2012173029 cites W1971990805 @default.
- W2012173029 cites W1973216353 @default.
- W2012173029 cites W1973994559 @default.
- W2012173029 cites W1976845082 @default.
- W2012173029 cites W197695037 @default.
- W2012173029 cites W1979341891 @default.
- W2012173029 cites W1988254695 @default.
- W2012173029 cites W1993537924 @default.
- W2012173029 cites W1993959754 @default.
- W2012173029 cites W1997256771 @default.
- W2012173029 cites W1998840552 @default.
- W2012173029 cites W1999511589 @default.
- W2012173029 cites W2003414730 @default.
- W2012173029 cites W2004070779 @default.
- W2012173029 cites W2006034152 @default.
- W2012173029 cites W2007389609 @default.
- W2012173029 cites W2012214033 @default.
- W2012173029 cites W2015463128 @default.
- W2012173029 cites W2017431783 @default.
- W2012173029 cites W2018070696 @default.
- W2012173029 cites W2020802809 @default.
- W2012173029 cites W2022715357 @default.
- W2012173029 cites W2023716497 @default.
- W2012173029 cites W2024565627 @default.
- W2012173029 cites W2026303819 @default.
- W2012173029 cites W2028858815 @default.
- W2012173029 cites W2032223695 @default.
- W2012173029 cites W2035252904 @default.
- W2012173029 cites W2035440704 @default.
- W2012173029 cites W2036062598 @default.
- W2012173029 cites W2036985020 @default.
- W2012173029 cites W2041730776 @default.
- W2012173029 cites W204319588 @default.
- W2012173029 cites W2045040998 @default.
- W2012173029 cites W2046158242 @default.
- W2012173029 cites W2049588693 @default.
- W2012173029 cites W2054828777 @default.
- W2012173029 cites W2055523179 @default.
- W2012173029 cites W2056348803 @default.
- W2012173029 cites W2061576298 @default.
- W2012173029 cites W2065827234 @default.
- W2012173029 cites W2068477037 @default.
- W2012173029 cites W2071695496 @default.
- W2012173029 cites W2077290313 @default.
- W2012173029 cites W2077776487 @default.
- W2012173029 cites W2078280064 @default.
- W2012173029 cites W2080366445 @default.
- W2012173029 cites W2081219796 @default.
- W2012173029 cites W2082357989 @default.
- W2012173029 cites W2083165938 @default.
- W2012173029 cites W2084419295 @default.
- W2012173029 cites W2085447556 @default.
- W2012173029 cites W2085981166 @default.
- W2012173029 cites W2102493638 @default.
- W2012173029 cites W2106182781 @default.
- W2012173029 cites W2108676263 @default.
- W2012173029 cites W2111843842 @default.
- W2012173029 cites W2112886974 @default.
- W2012173029 cites W2116284017 @default.
- W2012173029 cites W2116784956 @default.
- W2012173029 cites W2117197980 @default.
- W2012173029 cites W2118416388 @default.
- W2012173029 cites W2120338367 @default.
- W2012173029 cites W2128838531 @default.
- W2012173029 cites W2134144722 @default.
- W2012173029 cites W2137528165 @default.
- W2012173029 cites W2145890122 @default.
- W2012173029 cites W2149954869 @default.
- W2012173029 cites W2157710709 @default.
- W2012173029 cites W2162666574 @default.
- W2012173029 cites W2163957821 @default.
- W2012173029 cites W2167314970 @default.
- W2012173029 cites W2213967134 @default.
- W2012173029 cites W2327382154 @default.
- W2012173029 cites W2407976149 @default.
- W2012173029 cites W2410757758 @default.
- W2012173029 cites W2412922546 @default.
- W2012173029 cites W38748857 @default.
- W2012173029 doi "https://doi.org/10.1016/s0022-3956(02)00006-7" @default.
- W2012173029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12127594" @default.
- W2012173029 hasPublicationYear "2002" @default.