FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012174175> ?p ?o ?g. }

• W2012174175 endingPage "373" @default.
• W2012174175 startingPage "365" @default.
• W2012174175 abstract "Background: Clofazimine is potentially useful for the treatment of disease due to multidrug resistant Mycobacterium tuberculosis, as well as leprosy and certain chronic skin diseases. Its pharmacokinetics have been incompletely characterized. This study was conducted to explore issues relating to bioavailability in the presence of food, orange juice, and antacid. Methods: A 5 drug regimen consisting of clofazimine, cycloserine, ethionamide, para-aminosalicyclic acid, and pyridoxime was administered to healthy subjects four times using a four period cross-over design with two weeks washout between treatments. Subjects also received orange juice, a high fat meal, aluminum/magnesium antacid, or only water in random order with the drug regimen. The pharmacokinetics of clofazimine were assessed using individual- and population-based methods and relative bioavailability compared to fasting administration was determined. Results: Clofazimine exhibited a sometimes prolonged and variable lag-time and considerable variability in plasma concentrations. From the population analysis (one-compartment model), the mean oral clearance was 76.7 l/h (CV=74.2%) and mean apparent volume of distribution was 1470 l (CV=36.3%). The first-order absorption rate constant ranged from 0.716 to 1.33 h−1 (pooled CV=61.7%). Residual (proportional) error was 49.1%. Estimates of bioavailability compared to fasting administration were 145% (90% CI, 107–183%) for administration with high fat food, 82.0% (63.2–101%) for administration with orange juice, and 78.5% (55.1–102%) for administration with antacid. Conclusion: Administration of clofazimine with a high fat meal provides the greatest bioavailability, however, bioavailability is associated with high inter- and intra-subject variability. Both orange juice and aluminum-magnesium antacid produced a reduction in mean bioavailability of clofazimine." @default.
• W2012174175 created "2016-06-24" @default.
• W2012174175 creator A5003653275 @default.
• W2012174175 creator A5019494975 @default.
• W2012174175 creator A5024193573 @default.
• W2012174175 creator A5029547047 @default.
• W2012174175 creator A5055231042 @default.
• W2012174175 creator A5070014041 @default.
• W2012174175 date "2004-01-01" @default.
• W2012174175 modified "2023-10-08" @default.
• W2012174175 title "Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid" @default.
• W2012174175 cites W1550111394 @default.
• W2012174175 cites W1963975384 @default.
• W2012174175 cites W2066464642 @default.
• W2012174175 cites W2080031358 @default.
• W2012174175 cites W2101227663 @default.
• W2012174175 cites W2114292367 @default.
• W2012174175 cites W2145316521 @default.
• W2012174175 cites W2165247500 @default.
• W2012174175 cites W2417159818 @default.
• W2012174175 doi "https://doi.org/10.1016/j.tube.2004.04.001" @default.
• W2012174175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15525560" @default.
• W2012174175 hasPublicationYear "2004" @default.
• W2012174175 type Work @default.
• W2012174175 sameAs 2012174175 @default.
• W2012174175 citedByCount "68" @default.
• W2012174175 countsByYear W20121741752012 @default.
• W2012174175 countsByYear W20121741752013 @default.
• W2012174175 countsByYear W20121741752014 @default.
• W2012174175 countsByYear W20121741752015 @default.
• W2012174175 countsByYear W20121741752016 @default.
• W2012174175 countsByYear W20121741752017 @default.
• W2012174175 countsByYear W20121741752018 @default.
• W2012174175 countsByYear W20121741752019 @default.
• W2012174175 countsByYear W20121741752020 @default.
• W2012174175 countsByYear W20121741752021 @default.
• W2012174175 countsByYear W20121741752022 @default.
• W2012174175 countsByYear W20121741752023 @default.
• W2012174175 crossrefType "journal-article" @default.
• W2012174175 hasAuthorship W2012174175A5003653275 @default.
• W2012174175 hasAuthorship W2012174175A5019494975 @default.
• W2012174175 hasAuthorship W2012174175A5024193573 @default.
• W2012174175 hasAuthorship W2012174175A5029547047 @default.
• W2012174175 hasAuthorship W2012174175A5055231042 @default.
• W2012174175 hasAuthorship W2012174175A5070014041 @default.
• W2012174175 hasConcept C112705442 @default.
• W2012174175 hasConcept C126322002 @default.
• W2012174175 hasConcept C139254425 @default.
• W2012174175 hasConcept C181389837 @default.
• W2012174175 hasConcept C185592680 @default.
• W2012174175 hasConcept C203014093 @default.
• W2012174175 hasConcept C22979827 @default.
• W2012174175 hasConcept C2776297342 @default.
• W2012174175 hasConcept C2776768635 @default.
• W2012174175 hasConcept C2777056448 @default.
• W2012174175 hasConcept C2780590083 @default.
• W2012174175 hasConcept C2780695269 @default.
• W2012174175 hasConcept C2908647359 @default.
• W2012174175 hasConcept C2992423453 @default.
• W2012174175 hasConcept C31903555 @default.
• W2012174175 hasConcept C6557445 @default.
• W2012174175 hasConcept C71924100 @default.
• W2012174175 hasConcept C86803240 @default.
• W2012174175 hasConcept C98274493 @default.
• W2012174175 hasConcept C99454951 @default.
• W2012174175 hasConceptScore W2012174175C112705442 @default.
• W2012174175 hasConceptScore W2012174175C126322002 @default.
• W2012174175 hasConceptScore W2012174175C139254425 @default.
• W2012174175 hasConceptScore W2012174175C181389837 @default.
• W2012174175 hasConceptScore W2012174175C185592680 @default.
• W2012174175 hasConceptScore W2012174175C203014093 @default.
• W2012174175 hasConceptScore W2012174175C22979827 @default.
• W2012174175 hasConceptScore W2012174175C2776297342 @default.
• W2012174175 hasConceptScore W2012174175C2776768635 @default.
• W2012174175 hasConceptScore W2012174175C2777056448 @default.
• W2012174175 hasConceptScore W2012174175C2780590083 @default.
• W2012174175 hasConceptScore W2012174175C2780695269 @default.
• W2012174175 hasConceptScore W2012174175C2908647359 @default.
• W2012174175 hasConceptScore W2012174175C2992423453 @default.
• W2012174175 hasConceptScore W2012174175C31903555 @default.
• W2012174175 hasConceptScore W2012174175C6557445 @default.
• W2012174175 hasConceptScore W2012174175C71924100 @default.
• W2012174175 hasConceptScore W2012174175C86803240 @default.
• W2012174175 hasConceptScore W2012174175C98274493 @default.
• W2012174175 hasConceptScore W2012174175C99454951 @default.
• W2012174175 hasIssue "6" @default.
• W2012174175 hasLocation W20121741751 @default.
• W2012174175 hasLocation W20121741752 @default.
• W2012174175 hasOpenAccess W2012174175 @default.
• W2012174175 hasPrimaryLocation W20121741751 @default.
• W2012174175 hasRelatedWork W16306054 @default.
• W2012174175 hasRelatedWork W1965144549 @default.
• W2012174175 hasRelatedWork W2041168948 @default.
• W2012174175 hasRelatedWork W2048203385 @default.
• W2012174175 hasRelatedWork W2053148793 @default.
• W2012174175 hasRelatedWork W2071711748 @default.
• W2012174175 hasRelatedWork W2291779966 @default.
• W2012174175 hasRelatedWork W3164314033 @default.

• next