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- W2012174763 abstract "Thirty-two years ago at this Cold Spring Harbor meeting, we demonstrated that in situ nucleoside-labeled thymocytes emigrated from the thymus to peripheral lymphoid organs, into what is now known as the T-celldomains (Weissman 1967). The ability to mark unequivocally a population of cells or their subsets opened theway to the study of lymphocyte maturation from clonogenic hematopoietic precursors, to begin the analysis ofhematolymphoid cell lineages and distinct stages in theirmaturation pathways, as well as the adhesive molecules(called homing receptors) that emigrating lymphocytesuse to recognize and transmigrate through endothelia thatexpress complementary adhesive molecules (called addressins)(Cantor and Weissman 1976). In this paper, wereview our recent findings on lymphoid and myeloid maturation pathways, including the isolation of distinct lymphoid or myeloid clonogenic precursors, from pure populations of hematopoietic stem cells (HSC) and theirmultipotent clonogenic progeny. Although the mostabundant thymic early progenitors are classified asCD4–/lo CD8– CD3– CD25–CD44+c-Kit+ blast cells havedescribed a phenotypically defined subset of thymic cellswhich, when transferred at about 104 cells into the thymus, give rise to T, B, natural killer (NK), and CD8α+MHC II+lymphoid dendritic cells (Wu et al. 1991a, b,1996; Matsuzaki et al. 1993). We have recently isolated arare BM clonal common lymphocyte progenitor (CLP)which gives rise to T, B, and NK cells (Kondo et al.1997a). To begin to analyze the thymic processing o..." @default.
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- W2012174763 date "1999-01-01" @default.
- W2012174763 modified "2023-10-16" @default.
- W2012174763 title "Lymphoid Development from Stem Cells and the Common Lymphocyte Progenitors" @default.
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- W2012174763 doi "https://doi.org/10.1101/sqb.1999.64.1" @default.
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