FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012174834> ?p ?o ?g. }

• W2012174834 abstract "Cancer chemoprevention is considered one of the most promising areas in current cancer research, and asiaticoside, which is derived from the plant Centella asiatica, has a relative lack of systemic toxicity. The purpose of this study was to investigate whether asiaticoside is effective against 7,12-dimethylbenz(a)anthracene (DMBA)-induced carcinogenicity in vitro (MCF-7 and other cells) and in vivo (DMBA-induced rat cancer).An MTT assay was performed involving the treatment of MCF-7 cells for 48 h with H2O2 alone and H2O2 + different asiaticoside concentrations. Flow cytometry was performed, and the level of caspase 3, tumour necrosis factor-alpha (TNF-α) and interleukin-1 (IL-1) were quantified. Adult female Sprague-Dawley (SD) rats were divided into five groups designated I (control), II (DMBA-induced cancer), III (pre- and post-treatment with asiaticoside (200 μg/animal) in DMBA-induced cancer), IV (post-treatment with asiaticoside in DMBA-induced cancer), and V (treated with asiaticoside alone, drug control). Twelve weeks post-DMBA, rats developed mammary tumours. Rats either were sacrificed or imaged with MIBI. Histological examination of tumour tissues was performed. Tumour MIBI uptake ratios were determined. The data are expressed as the means ± standard deviation. Appropriate t-test and ANOVA statistical methods were used to compare data.The IC50 of asiaticoside for MCF-7 cells was determined to be 40 μM. Asiaticoside has potential for hydrogen peroxide cytotoxicity, and the caspase-3 activity increased with increasing asiaticoside dose in MCF-7 cells treated for 48 h. The expression of the cytokines TNF-α and IL-1β was significantly decreased and correlated with MIBI uptake ratios in vitro and in vivo after asiaticoside administration.This study demonstrates that asiaticoside is effective in vitro and in vivo in inducing apoptosis and enhancing anti-tumour activity." @default.
• W2012174834 created "2016-06-24" @default.
• W2012174834 creator A5069932424 @default.
• W2012174834 date "2014-03-25" @default.
• W2012174834 modified "2023-09-26" @default.
• W2012174834 title "Study of the cytotoxicity of asiaticoside on rats and tumour cells" @default.
• W2012174834 cites W1930076088 @default.
• W2012174834 cites W1971396647 @default.
• W2012174834 cites W1974556508 @default.
• W2012174834 cites W1975038491 @default.
• W2012174834 cites W1980697583 @default.
• W2012174834 cites W1981626224 @default.
• W2012174834 cites W1983070786 @default.
• W2012174834 cites W1988728666 @default.
• W2012174834 cites W1998339679 @default.
• W2012174834 cites W1999171842 @default.
• W2012174834 cites W2002341457 @default.
• W2012174834 cites W2010592796 @default.
• W2012174834 cites W2016541161 @default.
• W2012174834 cites W2020142855 @default.
• W2012174834 cites W2024312635 @default.
• W2012174834 cites W2028366359 @default.
• W2012174834 cites W2030609522 @default.
• W2012174834 cites W2037655828 @default.
• W2012174834 cites W2049402166 @default.
• W2012174834 cites W2049595805 @default.
• W2012174834 cites W2051148421 @default.
• W2012174834 cites W2058881098 @default.
• W2012174834 cites W2059011987 @default.
• W2012174834 cites W2061352113 @default.
• W2012174834 cites W2063756154 @default.
• W2012174834 cites W2067133221 @default.
• W2012174834 cites W2067310467 @default.
• W2012174834 cites W2074570728 @default.
• W2012174834 cites W2079226013 @default.
• W2012174834 cites W2079307566 @default.
• W2012174834 cites W2082397124 @default.
• W2012174834 cites W2086554707 @default.
• W2012174834 cites W2108658188 @default.
• W2012174834 cites W2120050118 @default.
• W2012174834 cites W2126668832 @default.
• W2012174834 cites W2324137972 @default.
• W2012174834 doi "https://doi.org/10.1186/1471-2407-14-220" @default.
• W2012174834 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3986932" @default.
• W2012174834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24667059" @default.
• W2012174834 hasPublicationYear "2014" @default.
• W2012174834 type Work @default.
• W2012174834 sameAs 2012174834 @default.
• W2012174834 citedByCount "30" @default.
• W2012174834 countsByYear W20121748342015 @default.
• W2012174834 countsByYear W20121748342016 @default.
• W2012174834 countsByYear W20121748342017 @default.
• W2012174834 countsByYear W20121748342018 @default.
• W2012174834 countsByYear W20121748342019 @default.
• W2012174834 countsByYear W20121748342020 @default.
• W2012174834 countsByYear W20121748342021 @default.
• W2012174834 countsByYear W20121748342022 @default.
• W2012174834 countsByYear W20121748342023 @default.
• W2012174834 crossrefType "journal-article" @default.
• W2012174834 hasAuthorship W2012174834A5069932424 @default.
• W2012174834 hasBestOaLocation W20121748341 @default.
• W2012174834 hasConcept C109316439 @default.
• W2012174834 hasConcept C121608353 @default.
• W2012174834 hasConcept C126322002 @default.
• W2012174834 hasConcept C150903083 @default.
• W2012174834 hasConcept C185592680 @default.
• W2012174834 hasConcept C202751555 @default.
• W2012174834 hasConcept C207001950 @default.
• W2012174834 hasConcept C2778938436 @default.
• W2012174834 hasConcept C502942594 @default.
• W2012174834 hasConcept C55493867 @default.
• W2012174834 hasConcept C555283112 @default.
• W2012174834 hasConcept C71924100 @default.
• W2012174834 hasConcept C86803240 @default.
• W2012174834 hasConcept C96232424 @default.
• W2012174834 hasConcept C98274493 @default.
• W2012174834 hasConceptScore W2012174834C109316439 @default.
• W2012174834 hasConceptScore W2012174834C121608353 @default.
• W2012174834 hasConceptScore W2012174834C126322002 @default.
• W2012174834 hasConceptScore W2012174834C150903083 @default.
• W2012174834 hasConceptScore W2012174834C185592680 @default.
• W2012174834 hasConceptScore W2012174834C202751555 @default.
• W2012174834 hasConceptScore W2012174834C207001950 @default.
• W2012174834 hasConceptScore W2012174834C2778938436 @default.
• W2012174834 hasConceptScore W2012174834C502942594 @default.
• W2012174834 hasConceptScore W2012174834C55493867 @default.
• W2012174834 hasConceptScore W2012174834C555283112 @default.
• W2012174834 hasConceptScore W2012174834C71924100 @default.
• W2012174834 hasConceptScore W2012174834C86803240 @default.
• W2012174834 hasConceptScore W2012174834C96232424 @default.
• W2012174834 hasConceptScore W2012174834C98274493 @default.
• W2012174834 hasIssue "1" @default.
• W2012174834 hasLocation W20121748341 @default.
• W2012174834 hasLocation W20121748342 @default.
• W2012174834 hasLocation W20121748343 @default.
• W2012174834 hasLocation W20121748344 @default.
• W2012174834 hasOpenAccess W2012174834 @default.
• W2012174834 hasPrimaryLocation W20121748341 @default.
• W2012174834 hasRelatedWork W1592261125 @default.
• W2012174834 hasRelatedWork W1982027601 @default.

• next