Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012175087> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2012175087 endingPage "187" @default.
- W2012175087 startingPage "177" @default.
- W2012175087 abstract "The high energy demands of the poorly myelinated long axon hippocampal and cortical neurons render these neurons selectively vulnerable to degeneration in Alzheimer’s disease. However, pathology engages all of the major elements of the neurovascular unit of the mature Alzheimer brain, the neurons, glia and blood vessels. Neurons present with retrograde degeneration of the axodendritic tree, capillaries with string vessels and markedly reduced densities and glia with signs of inflammatory activation. The neurons, capillaries and astrocytes of the mature Alzheimer brain harbor structurally defective mitochondria. Clinically, reduced glucose utilization, decades before cognitive deterioration, betrays ongoing energy insufficiency. β-hydroxybutyrate and γ-hydroxybutyrate can both provide energy to the brain when glucose utilization is blocked. Early work in mouse models of Alzheimer’s disease demonstrate their ability to reverse the pathological changes in the Alzheimer brain and initial clinical trials reveal their ability to improve cognition and every day function. Supplying the brain with energy holds great promise for delaying the onset of Alzheimer’s disease and slowing its progress." @default.
- W2012175087 created "2016-06-24" @default.
- W2012175087 creator A5035393503 @default.
- W2012175087 date "1978-05-01" @default.
- W2012175087 modified "2023-09-23" @default.
- W2012175087 title "The effects of gamma-hydroxybutyrate and gamma-butyrolactone upon the energy metabolism of the normoxic and hypoxic rat brain" @default.
- W2012175087 cites W1536351550 @default.
- W2012175087 cites W1598010376 @default.
- W2012175087 cites W1964021958 @default.
- W2012175087 cites W1968411767 @default.
- W2012175087 cites W1968693087 @default.
- W2012175087 cites W1972890541 @default.
- W2012175087 cites W1982034223 @default.
- W2012175087 cites W1986400194 @default.
- W2012175087 cites W1986829767 @default.
- W2012175087 cites W2016250406 @default.
- W2012175087 cites W2038862011 @default.
- W2012175087 cites W2048529508 @default.
- W2012175087 cites W2054538906 @default.
- W2012175087 cites W2060781300 @default.
- W2012175087 cites W2074004960 @default.
- W2012175087 cites W2076354295 @default.
- W2012175087 cites W2076671827 @default.
- W2012175087 cites W2077400387 @default.
- W2012175087 cites W2077450279 @default.
- W2012175087 cites W2090219231 @default.
- W2012175087 cites W2091982478 @default.
- W2012175087 cites W2094622667 @default.
- W2012175087 cites W2125185978 @default.
- W2012175087 cites W2129574196 @default.
- W2012175087 cites W2148950496 @default.
- W2012175087 doi "https://doi.org/10.1016/0006-8993(78)90229-9" @default.
- W2012175087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25695" @default.
- W2012175087 hasPublicationYear "1978" @default.
- W2012175087 type Work @default.
- W2012175087 sameAs 2012175087 @default.
- W2012175087 citedByCount "28" @default.
- W2012175087 countsByYear W20121750872012 @default.
- W2012175087 countsByYear W20121750872017 @default.
- W2012175087 countsByYear W20121750872023 @default.
- W2012175087 crossrefType "journal-article" @default.
- W2012175087 hasAuthorship W2012175087A5035393503 @default.
- W2012175087 hasConcept C142724271 @default.
- W2012175087 hasConcept C148762608 @default.
- W2012175087 hasConcept C169760540 @default.
- W2012175087 hasConcept C169900460 @default.
- W2012175087 hasConcept C2777670902 @default.
- W2012175087 hasConcept C2778794669 @default.
- W2012175087 hasConcept C2779134260 @default.
- W2012175087 hasConcept C2779354088 @default.
- W2012175087 hasConcept C2779483572 @default.
- W2012175087 hasConcept C2779530196 @default.
- W2012175087 hasConcept C2984863031 @default.
- W2012175087 hasConcept C2993665655 @default.
- W2012175087 hasConcept C502032728 @default.
- W2012175087 hasConcept C71924100 @default.
- W2012175087 hasConcept C86803240 @default.
- W2012175087 hasConceptScore W2012175087C142724271 @default.
- W2012175087 hasConceptScore W2012175087C148762608 @default.
- W2012175087 hasConceptScore W2012175087C169760540 @default.
- W2012175087 hasConceptScore W2012175087C169900460 @default.
- W2012175087 hasConceptScore W2012175087C2777670902 @default.
- W2012175087 hasConceptScore W2012175087C2778794669 @default.
- W2012175087 hasConceptScore W2012175087C2779134260 @default.
- W2012175087 hasConceptScore W2012175087C2779354088 @default.
- W2012175087 hasConceptScore W2012175087C2779483572 @default.
- W2012175087 hasConceptScore W2012175087C2779530196 @default.
- W2012175087 hasConceptScore W2012175087C2984863031 @default.
- W2012175087 hasConceptScore W2012175087C2993665655 @default.
- W2012175087 hasConceptScore W2012175087C502032728 @default.
- W2012175087 hasConceptScore W2012175087C71924100 @default.
- W2012175087 hasConceptScore W2012175087C86803240 @default.
- W2012175087 hasIssue "1" @default.
- W2012175087 hasLocation W20121750871 @default.
- W2012175087 hasLocation W20121750872 @default.
- W2012175087 hasOpenAccess W2012175087 @default.
- W2012175087 hasPrimaryLocation W20121750871 @default.
- W2012175087 hasRelatedWork W1964589606 @default.
- W2012175087 hasRelatedWork W2069027292 @default.
- W2012175087 hasRelatedWork W2070049573 @default.
- W2012175087 hasRelatedWork W2079053547 @default.
- W2012175087 hasRelatedWork W2082002278 @default.
- W2012175087 hasRelatedWork W2123119296 @default.
- W2012175087 hasRelatedWork W2412133698 @default.
- W2012175087 hasRelatedWork W313460363 @default.
- W2012175087 hasRelatedWork W3152542263 @default.
- W2012175087 hasRelatedWork W4220861288 @default.
- W2012175087 hasVolume "146" @default.
- W2012175087 isParatext "false" @default.
- W2012175087 isRetracted "false" @default.
- W2012175087 magId "2012175087" @default.
- W2012175087 workType "article" @default.