FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012175118> ?p ?o ?g. }

• W2012175118 endingPage "e60820" @default.
• W2012175118 startingPage "e60820" @default.
• W2012175118 abstract "The liver stages of Plasmodium parasites are important targets for the development of anti-malarial vaccine candidates and chemoprophylaxis approaches that aim to prevent clinical infection. Analyzing the impact of interventions on liver stages in the murine malaria model system Plasmodium yoelii has been cumbersome and requires terminal procedures. In vivo imaging of bioluminescent parasites has previously been shown to be an effective and non-invasive alternative to monitoring liver stage burden in the Plasmodium berghei model. Here we report the generation and characterization of a transgenic P. yoelii parasite expressing the reporter protein luciferase throughout the parasite life cycle. In vivo bioluminescent imaging of these parasites allows for quantitative analysis of P. yoelii liver stage burden and parasite development, which is comparable to quantitative RT-PCR analysis of liver infection. Using this system, we show that both BALB/cJ and C57BL/6 mice show comparable susceptibility to P. yoelii infection with sporozoites and that bioluminescent imaging can be used to monitor protective efficacy of attenuated parasite immunizations. Thus, this rapid, simple and noninvasive method for monitoring P. yoelii infection in the liver provides an efficient system to screen and evaluate the effects of anti-malarial interventions in vivo and in real-time." @default.
• W2012175118 created "2016-06-24" @default.
• W2012175118 creator A5014639053 @default.
• W2012175118 creator A5018427690 @default.
• W2012175118 creator A5031619204 @default.
• W2012175118 creator A5041155495 @default.
• W2012175118 creator A5069042958 @default.
• W2012175118 creator A5078495000 @default.
• W2012175118 creator A5080586091 @default.
• W2012175118 creator A5083029425 @default.
• W2012175118 date "2013-04-11" @default.
• W2012175118 modified "2023-09-28" @default.
• W2012175118 title "Quantitative Bioluminescent Imaging of Pre-Erythrocytic Malaria Parasite Infection Using Luciferase-Expressing Plasmodium yoelii" @default.
• W2012175118 cites W1559415647 @default.
• W2012175118 cites W1595024798 @default.
• W2012175118 cites W1931794862 @default.
• W2012175118 cites W1964881024 @default.
• W2012175118 cites W1987129114 @default.
• W2012175118 cites W2005313354 @default.
• W2012175118 cites W2005796976 @default.
• W2012175118 cites W2024290332 @default.
• W2012175118 cites W2036106668 @default.
• W2012175118 cites W2040611232 @default.
• W2012175118 cites W2060220636 @default.
• W2012175118 cites W2064987052 @default.
• W2012175118 cites W2066593591 @default.
• W2012175118 cites W2097370940 @default.
• W2012175118 cites W2103275420 @default.
• W2012175118 cites W2123039454 @default.
• W2012175118 cites W2138915152 @default.
• W2012175118 cites W2162355257 @default.
• W2012175118 cites W2171516424 @default.
• W2012175118 cites W2283324652 @default.
• W2012175118 doi "https://doi.org/10.1371/journal.pone.0060820" @default.
• W2012175118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3623966" @default.
• W2012175118 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23593316" @default.
• W2012175118 hasPublicationYear "2013" @default.
• W2012175118 type Work @default.
• W2012175118 sameAs 2012175118 @default.
• W2012175118 citedByCount "55" @default.
• W2012175118 countsByYear W20121751182014 @default.
• W2012175118 countsByYear W20121751182015 @default.
• W2012175118 countsByYear W20121751182016 @default.
• W2012175118 countsByYear W20121751182017 @default.
• W2012175118 countsByYear W20121751182018 @default.
• W2012175118 countsByYear W20121751182019 @default.
• W2012175118 countsByYear W20121751182020 @default.
• W2012175118 countsByYear W20121751182021 @default.
• W2012175118 countsByYear W20121751182022 @default.
• W2012175118 countsByYear W20121751182023 @default.
• W2012175118 crossrefType "journal-article" @default.
• W2012175118 hasAuthorship W2012175118A5014639053 @default.
• W2012175118 hasAuthorship W2012175118A5018427690 @default.
• W2012175118 hasAuthorship W2012175118A5031619204 @default.
• W2012175118 hasAuthorship W2012175118A5041155495 @default.
• W2012175118 hasAuthorship W2012175118A5069042958 @default.
• W2012175118 hasAuthorship W2012175118A5078495000 @default.
• W2012175118 hasAuthorship W2012175118A5080586091 @default.
• W2012175118 hasAuthorship W2012175118A5083029425 @default.
• W2012175118 hasBestOaLocation W20121751181 @default.
• W2012175118 hasConcept C104317684 @default.
• W2012175118 hasConcept C111335760 @default.
• W2012175118 hasConcept C136764020 @default.
• W2012175118 hasConcept C150903083 @default.
• W2012175118 hasConcept C159047783 @default.
• W2012175118 hasConcept C161997846 @default.
• W2012175118 hasConcept C203014093 @default.
• W2012175118 hasConcept C207001950 @default.
• W2012175118 hasConcept C2775867548 @default.
• W2012175118 hasConcept C2776486806 @default.
• W2012175118 hasConcept C2777237215 @default.
• W2012175118 hasConcept C2778048844 @default.
• W2012175118 hasConcept C2778371730 @default.
• W2012175118 hasConcept C2778675580 @default.
• W2012175118 hasConcept C41008148 @default.
• W2012175118 hasConcept C5176359 @default.
• W2012175118 hasConcept C54009773 @default.
• W2012175118 hasConcept C55493867 @default.
• W2012175118 hasConcept C71928629 @default.
• W2012175118 hasConcept C86803240 @default.
• W2012175118 hasConcept C89423630 @default.
• W2012175118 hasConceptScore W2012175118C104317684 @default.
• W2012175118 hasConceptScore W2012175118C111335760 @default.
• W2012175118 hasConceptScore W2012175118C136764020 @default.
• W2012175118 hasConceptScore W2012175118C150903083 @default.
• W2012175118 hasConceptScore W2012175118C159047783 @default.
• W2012175118 hasConceptScore W2012175118C161997846 @default.
• W2012175118 hasConceptScore W2012175118C203014093 @default.
• W2012175118 hasConceptScore W2012175118C207001950 @default.
• W2012175118 hasConceptScore W2012175118C2775867548 @default.
• W2012175118 hasConceptScore W2012175118C2776486806 @default.
• W2012175118 hasConceptScore W2012175118C2777237215 @default.
• W2012175118 hasConceptScore W2012175118C2778048844 @default.
• W2012175118 hasConceptScore W2012175118C2778371730 @default.
• W2012175118 hasConceptScore W2012175118C2778675580 @default.
• W2012175118 hasConceptScore W2012175118C41008148 @default.
• W2012175118 hasConceptScore W2012175118C5176359 @default.
• W2012175118 hasConceptScore W2012175118C54009773 @default.

• next