Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012175414> ?p ?o ?g. }
- W2012175414 endingPage "e9066" @default.
- W2012175414 startingPage "e9066" @default.
- W2012175414 abstract "The BCL-2 family of proteins includes pro- and antiapoptotic members acting by controlling the permeabilization of mitochondria. Although the association of these proteins with the outer mitochondrial membrane is crucial for their function, little is known about the characteristics of this interaction.Here, we followed a reductionist approach to clarify to what extent membrane-active regions of homologous BCL-2 family proteins contribute to their functional divergence. Using isolated mitochondria as well as model lipid Langmuir monolayers coupled with Brewster Angle Microscopy, we explored systematically and comparatively the membrane activity and membrane-peptide interactions of fragments derived from the central helical hairpin of BAX, BCL-xL and BID. The results show a connection between the differing abilities of the assayed peptide fragments to contact, insert, destabilize and porate membranes and the activity of their cognate proteins in programmed cell death.BCL-2 family-derived pore-forming helices thus represent structurally analogous, but functionally dissimilar membrane domains." @default.
- W2012175414 created "2016-06-24" @default.
- W2012175414 creator A5002553667 @default.
- W2012175414 creator A5003059028 @default.
- W2012175414 creator A5019373560 @default.
- W2012175414 creator A5039274632 @default.
- W2012175414 creator A5042100249 @default.
- W2012175414 creator A5051984835 @default.
- W2012175414 creator A5055417982 @default.
- W2012175414 creator A5066324996 @default.
- W2012175414 creator A5066710763 @default.
- W2012175414 creator A5084970496 @default.
- W2012175414 date "2010-02-05" @default.
- W2012175414 modified "2023-09-25" @default.
- W2012175414 title "Active Fragments from Pro- and Antiapoptotic BCL-2 Proteins Have Distinct Membrane Behavior Reflecting Their Functional Divergence" @default.
- W2012175414 cites W1569409978 @default.
- W2012175414 cites W1864196235 @default.
- W2012175414 cites W1893801352 @default.
- W2012175414 cites W1965217295 @default.
- W2012175414 cites W1967828766 @default.
- W2012175414 cites W1969445527 @default.
- W2012175414 cites W1972547501 @default.
- W2012175414 cites W1973258944 @default.
- W2012175414 cites W1975727111 @default.
- W2012175414 cites W1977258127 @default.
- W2012175414 cites W1980254337 @default.
- W2012175414 cites W1980298403 @default.
- W2012175414 cites W1981810393 @default.
- W2012175414 cites W1981984118 @default.
- W2012175414 cites W1982722263 @default.
- W2012175414 cites W1983591095 @default.
- W2012175414 cites W1984547206 @default.
- W2012175414 cites W1986375652 @default.
- W2012175414 cites W1988113635 @default.
- W2012175414 cites W1991303866 @default.
- W2012175414 cites W1991639194 @default.
- W2012175414 cites W1994611236 @default.
- W2012175414 cites W1998595310 @default.
- W2012175414 cites W1999317859 @default.
- W2012175414 cites W2000069497 @default.
- W2012175414 cites W2002919668 @default.
- W2012175414 cites W2003472250 @default.
- W2012175414 cites W2003897459 @default.
- W2012175414 cites W2012076962 @default.
- W2012175414 cites W2013364831 @default.
- W2012175414 cites W2014122625 @default.
- W2012175414 cites W2014999693 @default.
- W2012175414 cites W2017991274 @default.
- W2012175414 cites W2019510578 @default.
- W2012175414 cites W2022416087 @default.
- W2012175414 cites W2022803736 @default.
- W2012175414 cites W2024505421 @default.
- W2012175414 cites W2030546970 @default.
- W2012175414 cites W2031315018 @default.
- W2012175414 cites W2031793643 @default.
- W2012175414 cites W2032221839 @default.
- W2012175414 cites W2033873142 @default.
- W2012175414 cites W2038628700 @default.
- W2012175414 cites W204126668 @default.
- W2012175414 cites W2042175504 @default.
- W2012175414 cites W2043308148 @default.
- W2012175414 cites W2051575178 @default.
- W2012175414 cites W2053534788 @default.
- W2012175414 cites W2055309496 @default.
- W2012175414 cites W2056848910 @default.
- W2012175414 cites W2058971946 @default.
- W2012175414 cites W2063154392 @default.
- W2012175414 cites W2063362926 @default.
- W2012175414 cites W2067130864 @default.
- W2012175414 cites W2067204369 @default.
- W2012175414 cites W2071917878 @default.
- W2012175414 cites W2073028327 @default.
- W2012175414 cites W2076011398 @default.
- W2012175414 cites W2083121251 @default.
- W2012175414 cites W2088693828 @default.
- W2012175414 cites W2090155976 @default.
- W2012175414 cites W2091483784 @default.
- W2012175414 cites W2092759765 @default.
- W2012175414 cites W2095122505 @default.
- W2012175414 cites W2095308878 @default.
- W2012175414 cites W2095490475 @default.
- W2012175414 cites W2096541685 @default.
- W2012175414 cites W2099410111 @default.
- W2012175414 cites W2100721448 @default.
- W2012175414 cites W2104160876 @default.
- W2012175414 cites W2106009840 @default.
- W2012175414 cites W2106968343 @default.
- W2012175414 cites W2107427982 @default.
- W2012175414 cites W2107434475 @default.
- W2012175414 cites W2111941604 @default.
- W2012175414 cites W2130361718 @default.
- W2012175414 cites W2133475822 @default.
- W2012175414 cites W2134872883 @default.
- W2012175414 cites W2140372706 @default.
- W2012175414 cites W2143190256 @default.
- W2012175414 cites W2147318282 @default.
- W2012175414 cites W2147760686 @default.
- W2012175414 cites W2150315067 @default.