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• W2012177665 abstract "Aim The activity of carboplatin was evaluated in a phase II window study in previously untreated children with metastatic soft tissue sarcoma. Methods Children with poor-risk metastatic disease (over 10 years and/or with bone/bone marrow involvement) treated in the SIOP MMT 98 study were scheduled to receive two courses of intravenous carboplatin (area under curve [AUC] of 10), 21 days apart. Results Sixteen eligible patients were entered into the rhabdomyosarcoma (RMS) group. Response (complete remission or partial remission) was seen in five children (31%, 95% confidence interval (CI) 14–56%). Ten eligible patients with other soft tissue sarcomas were recruited into the non-RMS group. Two responses (20%, 95% CI 6–51%) were seen. Toxicity in both groups was predictable nausea, vomiting and marrow suppression and there were no toxic deaths. Conclusion Single-agent carboplatin at AUC of 10 has an acceptable toxicity profile but only moderate efficacy in poor-risk metastatic soft tissue sarcoma." @default.
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• W2012177665 date "2007-11-01" @default.
• W2012177665 modified "2023-10-17" @default.
• W2012177665 title "Efficacy of carboplatin given in a phase II window study to children and adolescents with newly diagnosed metastatic soft tissue sarcoma" @default.
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• W2012177665 doi "https://doi.org/10.1016/j.ejca.2007.08.024" @default.
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