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- W2012178632 abstract "Sera of 76 HIV-negative hemophilia patients, 103 HIV-positive (HIV+) hemophilia patients free of AIDS or AIDS related complex (ARC), and 32 HIV+ hemophilia patients with AIDS/ARC were tested for four different anti-IgG activities. IgG-anti-F(ab')2γ, IgM-anti-F(ab')2γ, and IgG-anti-Fcγ serum activities were significantly associated with the clinical stage of HIV infection, whereas IgM-anti-Fcγ was not. IgG-anti-F(ab')2γ activity was found to be caused by cross-reaction of anti-HIV antibody with an epitope within the constant CHI domain of human IgG. HIV+ hemophilia patients with severe thrombocytopenia (< 50,000/μl platelet counts) had significantly higher IgM-anti-IgG activity than patients with > 50,000/μl platelets. Because anti-IgG antibodies possess immunoregulatory properties, our results may serve as a possible explanation for the frequent B cell disorders encountered in HIV-infected patients." @default.
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- W2012178632 date "1992-05-01" @default.
- W2012178632 modified "2023-09-27" @default.
- W2012178632 title "Anti-IgG Autoantibodies in HIV-infected Hemophilia Patients" @default.
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- W2012178632 doi "https://doi.org/10.1111/j.1423-0410.1992.tb01203.x" @default.
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