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- W2012179552 abstract "Both the epithelium and the mesenchyme of the larval small intestine of anurans undergoes metamorphic conversion into the adult counterparts. The conversion of the mesenchyme has been poorly understood especially at the molecular level, whereas the changes of the epithelium have been extensively studied. The present study investigated the metamorphic changes of the mesenchyme of tadpoles of bullfrog, Rana catesbeiana, focusing on the expression of genes of type I collagen. By using the cDNA clones coding for α1(I) and α2(I) collagen as probes, expression of each collagen gene was examined. These genes were drastically up-regulated at the climax period of spontaneous metamorphosis, which was precociously mimicked by treating tadpoles with thyroid hormone. The increased expression of these genes at the climax stage was well correlated with the conversion of the thin larval mesenchyme to more thick and dense adult connective tissues of the intestine. In situ hybridization identified the fibroblasts that were actively expressing the collagen genes and, therefore, were thought to be responsible for the remodeling. These results strongly suggest that the expression of type I collagen genes is regulated during the intestinal remodeling in a cell-type specific and thyroid hormone-dependent manner." @default.
- W2012179552 created "2016-06-24" @default.
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- W2012179552 date "1999-02-01" @default.
- W2012179552 modified "2023-10-16" @default.
- W2012179552 title "Cell-type specific and thyroid hormone-dependent expression of genes of α1(I) and α2(I) collagen in intestine during amphibian metamorphosis" @default.
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- W2012179552 doi "https://doi.org/10.1016/s0945-053x(99)00005-0" @default.
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