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- W2012179673 endingPage "654" @default.
- W2012179673 startingPage "640" @default.
- W2012179673 abstract "Production of proteins requires the synthesis, maturation, and export of mRNAs before their translation in the cytoplasm. Endogenous and exogenous sources of DNA damage pose a challenge to the co-ordinated regulation of gene expression, because the integrity of the DNA template can be compromised by DNA lesions. Cells recognize and respond to this DNA damage through a variety of DNA damage responses (DDRs). Failure to deal with DNA damage appropriately can lead to genomic instability and cancer.The p53 tumor suppressor plays a dominant role in DDR-dependent changes in gene expression, but this transcription factor is not solely responsible for all changes. Recent evidence indicates that RNA metabolism is integral to DDRs as well. In particular, post-transcriptional processes are emerging as important contributors to these complex responses.Transcriptional, post-transcriptional, and translational regulation of gene expression is subject to changes in response to DNA damage. How these processes are intertwined in the unfolding of DDR is not fully understood.Many complex regulatory responses combine to determine cell fate after DNA damage. Understanding how transcriptional, post-transcriptional, and translational processes interdigitate to create a web of regulatory interactions will be one of the key challenges to fully understand DDRs." @default.
- W2012179673 created "2016-06-24" @default.
- W2012179673 creator A5030941843 @default.
- W2012179673 date "2014-02-01" @default.
- W2012179673 modified "2023-09-27" @default.
- W2012179673 title "Post-Transcriptional Regulation of DNA Damage-Responsive Gene Expression" @default.
- W2012179673 cites W123955279 @default.
- W2012179673 cites W1498528035 @default.
- W2012179673 cites W1507700987 @default.
- W2012179673 cites W1685856002 @default.
- W2012179673 cites W1884480099 @default.
- W2012179673 cites W1889725400 @default.
- W2012179673 cites W1906453721 @default.
- W2012179673 cites W1968631483 @default.
- W2012179673 cites W1969093811 @default.
- W2012179673 cites W1970365235 @default.
- W2012179673 cites W1971476329 @default.
- W2012179673 cites W1971687743 @default.
- W2012179673 cites W1971979374 @default.
- W2012179673 cites W1973480874 @default.
- W2012179673 cites W1975964287 @default.
- W2012179673 cites W1976538128 @default.
- W2012179673 cites W1977629626 @default.
- W2012179673 cites W1979261061 @default.
- W2012179673 cites W1983290059 @default.
- W2012179673 cites W1984276945 @default.
- W2012179673 cites W1984353960 @default.
- W2012179673 cites W1985785895 @default.
- W2012179673 cites W1986275572 @default.
- W2012179673 cites W1988313137 @default.
- W2012179673 cites W1989043763 @default.
- W2012179673 cites W1992807653 @default.
- W2012179673 cites W1992920916 @default.
- W2012179673 cites W1993807435 @default.
- W2012179673 cites W1995210348 @default.
- W2012179673 cites W1995987769 @default.
- W2012179673 cites W1997974981 @default.
- W2012179673 cites W2001439481 @default.
- W2012179673 cites W2001581014 @default.
- W2012179673 cites W2002203989 @default.
- W2012179673 cites W2005558505 @default.
- W2012179673 cites W2005762860 @default.
- W2012179673 cites W2009462679 @default.
- W2012179673 cites W2009581409 @default.
- W2012179673 cites W2013721931 @default.
- W2012179673 cites W2015384217 @default.
- W2012179673 cites W2015519364 @default.
- W2012179673 cites W2016601854 @default.
- W2012179673 cites W2017498643 @default.
- W2012179673 cites W2019414523 @default.
- W2012179673 cites W2021583109 @default.
- W2012179673 cites W2022037877 @default.
- W2012179673 cites W2025037044 @default.
- W2012179673 cites W2026945839 @default.
- W2012179673 cites W2027424106 @default.
- W2012179673 cites W2028468783 @default.
- W2012179673 cites W2028805078 @default.
- W2012179673 cites W2029006282 @default.
- W2012179673 cites W2030689322 @default.
- W2012179673 cites W2032742580 @default.
- W2012179673 cites W2033275544 @default.
- W2012179673 cites W2035000190 @default.
- W2012179673 cites W2036500104 @default.
- W2012179673 cites W2037915962 @default.
- W2012179673 cites W2038004197 @default.
- W2012179673 cites W2038038813 @default.
- W2012179673 cites W2038167014 @default.
- W2012179673 cites W2038424676 @default.
- W2012179673 cites W2039517575 @default.
- W2012179673 cites W2042316019 @default.
- W2012179673 cites W2045714098 @default.
- W2012179673 cites W2046815875 @default.
- W2012179673 cites W2047562490 @default.
- W2012179673 cites W2049462796 @default.
- W2012179673 cites W2055475675 @default.
- W2012179673 cites W2056151925 @default.
- W2012179673 cites W2056644877 @default.
- W2012179673 cites W2056826119 @default.
- W2012179673 cites W2059073003 @default.
- W2012179673 cites W2059848983 @default.
- W2012179673 cites W2059901912 @default.
- W2012179673 cites W2060148395 @default.
- W2012179673 cites W2060611832 @default.
- W2012179673 cites W2060708740 @default.
- W2012179673 cites W2061967634 @default.
- W2012179673 cites W2063678191 @default.
- W2012179673 cites W2065566217 @default.
- W2012179673 cites W2065776232 @default.
- W2012179673 cites W2067170092 @default.
- W2012179673 cites W2068287710 @default.
- W2012179673 cites W2068441965 @default.
- W2012179673 cites W2068540732 @default.
- W2012179673 cites W2070765029 @default.
- W2012179673 cites W2073282208 @default.
- W2012179673 cites W2079015277 @default.
- W2012179673 cites W2080940607 @default.
- W2012179673 cites W2081027578 @default.
- W2012179673 cites W2084229439 @default.