FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012180911> ?p ?o ?g. }

• W2012180911 endingPage "e0116892" @default.
• W2012180911 startingPage "e0116892" @default.
• W2012180911 abstract "Dermal Papillae (DP) is a unique population of mesenchymal cells that was shown to regulate hair follicle formation and growth cycle. During development most DP cells are derived from mesoderm, however, functionally equivalent DP cells of cephalic hairs originate from Neural Crest (NC). Here we directed human embryonic stem cells (hESCs) to generate first NC cells and then hair-inducing DP-like cells in culture. We showed that hESC-derived DP-like cells (hESC-DPs) express markers typically found in adult human DP cells (e.g., p-75, nestin, versican, SMA, alkaline phosphatase) and are able to induce hair follicle formation when transplanted under the skin of immunodeficient NUDE mice. Engineered to express GFP, hESC-derived DP-like cells incorporate into DP of newly formed hair follicles and express appropriate markers. We demonstrated that BMP signaling is critical for hESC-DP derivation since BMP inhibitor dorsomorphin completely eliminated hair-inducing activity from hESC-DP cultures. DP cells were proposed as the cell-based treatment for hair loss diseases. Unfortunately human DP cells are not suitable for this purpose because they cannot be obtained in necessary amounts and rapidly loose their ability to induce hair follicle formation when cultured. In this context derivation of functional hESC-DP cells capable of inducing a robust hair growth for the first time shown here can become an important finding for the biomedical science." @default.
• W2012180911 created "2016-06-24" @default.
• W2012180911 creator A5006161477 @default.
• W2012180911 creator A5030868732 @default.
• W2012180911 creator A5036475710 @default.
• W2012180911 creator A5049123217 @default.
• W2012180911 creator A5054833588 @default.
• W2012180911 creator A5067995641 @default.
• W2012180911 creator A5091739399 @default.
• W2012180911 date "2015-01-21" @default.
• W2012180911 modified "2023-10-10" @default.
• W2012180911 title "Derivation of Hair-Inducing Cell from Human Pluripotent Stem Cells" @default.
• W2012180911 cites W1523413432 @default.
• W2012180911 cites W1587942099 @default.
• W2012180911 cites W1970801772 @default.
• W2012180911 cites W1977260464 @default.
• W2012180911 cites W1979814807 @default.
• W2012180911 cites W1982527650 @default.
• W2012180911 cites W1982882278 @default.
• W2012180911 cites W1987407032 @default.
• W2012180911 cites W1992972287 @default.
• W2012180911 cites W2000051244 @default.
• W2012180911 cites W2003426511 @default.
• W2012180911 cites W2005963845 @default.
• W2012180911 cites W2013584852 @default.
• W2012180911 cites W2018449783 @default.
• W2012180911 cites W2019802654 @default.
• W2012180911 cites W2033221692 @default.
• W2012180911 cites W2034432190 @default.
• W2012180911 cites W2037059879 @default.
• W2012180911 cites W2043950060 @default.
• W2012180911 cites W2047642636 @default.
• W2012180911 cites W2048107295 @default.
• W2012180911 cites W2059126886 @default.
• W2012180911 cites W2062836206 @default.
• W2012180911 cites W2067760245 @default.
• W2012180911 cites W2073610802 @default.
• W2012180911 cites W2073750598 @default.
• W2012180911 cites W2075925079 @default.
• W2012180911 cites W2081628067 @default.
• W2012180911 cites W2093248108 @default.
• W2012180911 cites W2096903993 @default.
• W2012180911 cites W2102313656 @default.
• W2012180911 cites W2102560467 @default.
• W2012180911 cites W2107141327 @default.
• W2012180911 cites W2138562294 @default.
• W2012180911 cites W2138907299 @default.
• W2012180911 cites W2141178462 @default.
• W2012180911 cites W2150518449 @default.
• W2012180911 cites W2152426454 @default.
• W2012180911 cites W2159999899 @default.
• W2012180911 cites W2163133855 @default.
• W2012180911 cites W2165695219 @default.
• W2012180911 cites W2205931255 @default.
• W2012180911 cites W4239546167 @default.
• W2012180911 cites W2114197293 @default.
• W2012180911 doi "https://doi.org/10.1371/journal.pone.0116892" @default.
• W2012180911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4301813" @default.
• W2012180911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25607935" @default.
• W2012180911 hasPublicationYear "2015" @default.
• W2012180911 type Work @default.
• W2012180911 sameAs 2012180911 @default.
• W2012180911 citedByCount "50" @default.
• W2012180911 countsByYear W20121809112015 @default.
• W2012180911 countsByYear W20121809112016 @default.
• W2012180911 countsByYear W20121809112017 @default.
• W2012180911 countsByYear W20121809112018 @default.
• W2012180911 countsByYear W20121809112019 @default.
• W2012180911 countsByYear W20121809112020 @default.
• W2012180911 countsByYear W20121809112021 @default.
• W2012180911 countsByYear W20121809112022 @default.
• W2012180911 countsByYear W20121809112023 @default.
• W2012180911 crossrefType "journal-article" @default.
• W2012180911 hasAuthorship W2012180911A5006161477 @default.
• W2012180911 hasAuthorship W2012180911A5030868732 @default.
• W2012180911 hasAuthorship W2012180911A5036475710 @default.
• W2012180911 hasAuthorship W2012180911A5049123217 @default.
• W2012180911 hasAuthorship W2012180911A5054833588 @default.
• W2012180911 hasAuthorship W2012180911A5067995641 @default.
• W2012180911 hasAuthorship W2012180911A5091739399 @default.
• W2012180911 hasBestOaLocation W20121809111 @default.
• W2012180911 hasConcept C104317684 @default.
• W2012180911 hasConcept C126749454 @default.
• W2012180911 hasConcept C145103041 @default.
• W2012180911 hasConcept C148738053 @default.
• W2012180911 hasConcept C159470946 @default.
• W2012180911 hasConcept C189165786 @default.
• W2012180911 hasConcept C196843134 @default.
• W2012180911 hasConcept C198826908 @default.
• W2012180911 hasConcept C2777216303 @default.
• W2012180911 hasConcept C2779335624 @default.
• W2012180911 hasConcept C28328180 @default.
• W2012180911 hasConcept C55493867 @default.
• W2012180911 hasConcept C86803240 @default.
• W2012180911 hasConcept C95444343 @default.
• W2012180911 hasConceptScore W2012180911C104317684 @default.
• W2012180911 hasConceptScore W2012180911C126749454 @default.
• W2012180911 hasConceptScore W2012180911C145103041 @default.

• next