Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012183747> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2012183747 endingPage "68" @default.
- W2012183747 startingPage "57" @default.
- W2012183747 abstract "A total of 18 compounds consisting of 7 aliphatic and 7 aromatic bis(guanylhydrazones), p-quinone-bis(guanylhydrazone), one monoguanylhydrazone, one diamidine and one diguanidine were studied spectrophotometrically to determine their ability to interact with native calf-thymus DNA and the possible correlation of binding with biological activity. In each case, the ability of a compound to bind to DNA correlated with its ability to inhibit the activity of DNA-dependent DNA polymerase (EC 2.7.7.7) extracted from mouse leukemia L1210 cells. For example, all the aromatic bis-guanylhydrazones and diamidine (hydroxystilbamidine), which were good inhibitors of the enzyme activity, showed a biphasic interaction with DNA. All the aliphatic compounds displayed no detectable interaction with DNA in the Tris buffer used, and were also poor inhibitors of the polymerase activity. Interaction of decamethylene diguanide (Synthalin) with DNA could not be determined because the compound does not absorb light in the UV-VIS region. However, in similarity with other aliphatic compounds, this agent was a poor inhibitor of DNA polymerase reaction. The p-quinone-bis(guanylhydrazone) and p-phenylbenzaldehyde-monoguanylhydrazone showed only a monophasic interaction with DNA and caused an intermediate inhibition of the enzyme activity. When tested for possible anti-leukemic activity against i.p. L1210 leukemia in syngeneic DBA/2J mice, all the aromatic bisguanylhydrazones as well as hydroxystilbamidine caused prolongation of survival of tumor-bearing mice. Among the aliphatic bisguanylhydrazones, all of which showed no binding to DNA and caused at the most only a very slight inhibition of DNA polymerase, only methylglyoxal-bis(guanylhydrazone) (CH3-G) had antileukemic activity. Synthalin also inhibited leukemic growth. Evidences presented indicate that the mechanisms of action of aliphatic and aromatic bisguanylhydrazones may be quite different. Furthermore, the ability to bind to DNA may be a useful criterion to predict the antileukemic activity of aromatic guanylhydrazones and possibly other aromatic bis-cationic compounds, but not that of aliphatic congeners." @default.
- W2012183747 created "2016-06-24" @default.
- W2012183747 creator A5026467969 @default.
- W2012183747 creator A5063228708 @default.
- W2012183747 creator A5079009180 @default.
- W2012183747 date "1977-01-01" @default.
- W2012183747 modified "2023-09-25" @default.
- W2012183747 title "Studies on the structure—activity relationship among aliphatic and aromatic bisguanylhydrazones and some related compounds" @default.
- W2012183747 cites W1527556805 @default.
- W2012183747 cites W1595148502 @default.
- W2012183747 cites W1983427132 @default.
- W2012183747 cites W2024143416 @default.
- W2012183747 cites W2035782972 @default.
- W2012183747 cites W2043456004 @default.
- W2012183747 cites W2084419984 @default.
- W2012183747 cites W2092553400 @default.
- W2012183747 cites W2115713071 @default.
- W2012183747 cites W2212754122 @default.
- W2012183747 cites W2286275278 @default.
- W2012183747 cites W2397225959 @default.
- W2012183747 cites W99465270 @default.
- W2012183747 doi "https://doi.org/10.1016/0009-2797(77)90153-3" @default.
- W2012183747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/837465" @default.
- W2012183747 hasPublicationYear "1977" @default.
- W2012183747 type Work @default.
- W2012183747 sameAs 2012183747 @default.
- W2012183747 citedByCount "19" @default.
- W2012183747 countsByYear W20121837472022 @default.
- W2012183747 countsByYear W20121837472023 @default.
- W2012183747 crossrefType "journal-article" @default.
- W2012183747 hasAuthorship W2012183747A5026467969 @default.
- W2012183747 hasAuthorship W2012183747A5063228708 @default.
- W2012183747 hasAuthorship W2012183747A5079009180 @default.
- W2012183747 hasConcept C116073593 @default.
- W2012183747 hasConcept C153911025 @default.
- W2012183747 hasConcept C181199279 @default.
- W2012183747 hasConcept C185592680 @default.
- W2012183747 hasConcept C202751555 @default.
- W2012183747 hasConcept C2756471 @default.
- W2012183747 hasConcept C2780643102 @default.
- W2012183747 hasConcept C552990157 @default.
- W2012183747 hasConcept C55493867 @default.
- W2012183747 hasConcept C64241487 @default.
- W2012183747 hasConcept C71240020 @default.
- W2012183747 hasConcept C82381507 @default.
- W2012183747 hasConcept C86803240 @default.
- W2012183747 hasConceptScore W2012183747C116073593 @default.
- W2012183747 hasConceptScore W2012183747C153911025 @default.
- W2012183747 hasConceptScore W2012183747C181199279 @default.
- W2012183747 hasConceptScore W2012183747C185592680 @default.
- W2012183747 hasConceptScore W2012183747C202751555 @default.
- W2012183747 hasConceptScore W2012183747C2756471 @default.
- W2012183747 hasConceptScore W2012183747C2780643102 @default.
- W2012183747 hasConceptScore W2012183747C552990157 @default.
- W2012183747 hasConceptScore W2012183747C55493867 @default.
- W2012183747 hasConceptScore W2012183747C64241487 @default.
- W2012183747 hasConceptScore W2012183747C71240020 @default.
- W2012183747 hasConceptScore W2012183747C82381507 @default.
- W2012183747 hasConceptScore W2012183747C86803240 @default.
- W2012183747 hasIssue "1" @default.
- W2012183747 hasLocation W20121837471 @default.
- W2012183747 hasLocation W20121837472 @default.
- W2012183747 hasOpenAccess W2012183747 @default.
- W2012183747 hasPrimaryLocation W20121837471 @default.
- W2012183747 hasRelatedWork W1486256981 @default.
- W2012183747 hasRelatedWork W1489886741 @default.
- W2012183747 hasRelatedWork W2007830725 @default.
- W2012183747 hasRelatedWork W2007963428 @default.
- W2012183747 hasRelatedWork W2019375035 @default.
- W2012183747 hasRelatedWork W2066410887 @default.
- W2012183747 hasRelatedWork W2080778966 @default.
- W2012183747 hasRelatedWork W2088424033 @default.
- W2012183747 hasRelatedWork W2143117824 @default.
- W2012183747 hasRelatedWork W2259828804 @default.
- W2012183747 hasVolume "16" @default.
- W2012183747 isParatext "false" @default.
- W2012183747 isRetracted "false" @default.
- W2012183747 magId "2012183747" @default.
- W2012183747 workType "article" @default.