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- W2012184181 abstract "Acute as well as chronic treatment with ketanserin but not with ritanserin reduced the blood pressure in the spontaneously hypertensive rat, indicating that 5-HT2-receptor blockade alone does not have antihypertensive properties. Whereas the blood pressure reduction to acute administration of ketanserin was directly related to its ability to shift the dose-response curve of phenylephrine (α1-adrenergic blockade), the same relationship was not apparent following chronic treatment with ketanserin. This suggests that the 5-HT2- and α1-blockade may complement each other in reducing the blood pressure, a conclusion supported by the observation that in the conscious rat, 5-HT2-receptor blockade by ritanserin enhanced the hypotensive response to prazosin. However, ritanserin did not influence the ability of prazosin to antagonize pressor responses to phenylephrine in the pithed rat." @default.
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- W2012184181 date "1988-01-01" @default.
- W2012184181 modified "2023-09-27" @default.
- W2012184181 title "Antihypertensive Effects of Ketanserin and Ritanserin in the Spontaneously Hypertensive Rat" @default.
- W2012184181 doi "https://doi.org/10.1097/00005344-198800111-00006" @default.
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