FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012184356> ?p ?o ?g. }

• W2012184356 endingPage "240" @default.
• W2012184356 startingPage "227" @default.
• W2012184356 abstract "Leukocyte migration into the central nervous system (CNS) is mediated by chemokines expressed on CNS endothelial cell surfaces. This study investigated the production of chemokines and expression of chemokine receptors by human brain endothelial cells (HBECs) in vitro and in situ. Four chemokines (CCL2, CCL5, CXCL8, and CXCL10) were demonstrated by immunohistochemistry in endothelial cells in brain samples from patients with multiple sclerosis. CXCL8 and CCL2 were constitutively released and increased by primary HBECs and the brain endothelial cell line hCEMC/D3 in response to tumor necrosis factor and/or interferon γ. CXCL10 and CCL5 were undetectable in resting endothelial cells but were secreted in response to these proinflammatory cytokines. Tumor necrosis factor strongly increased the production of CCL2, CCL5, and CXCL8; interferon γ upregulated CXCL10 exclusively. CCL3 was not secreted by HBECs and seemed to be confined to astrocytes in situ. The chemokine receptors CXCR1 and CXCR3 were expressed by HBECs both in vitro and in situ; CXCR3 was upregulated in response to cytokine stimulation in vitro. In contrast, CXCR3 expression was reduced in noninflammatory (silent) multiple sclerosis lesions. The particularly high levels of CXCL10 and CXCL8 expressed by brain endothelium may contribute to the predominant TH1-type inflammatory response observed in chronic inflammatory conditions such as multiple sclerosis." @default.
• W2012184356 created "2016-06-24" @default.
• W2012184356 creator A5006054229 @default.
• W2012184356 creator A5013851751 @default.
• W2012184356 creator A5037523792 @default.
• W2012184356 creator A5037988586 @default.
• W2012184356 creator A5043128657 @default.
• W2012184356 creator A5052362796 @default.
• W2012184356 creator A5062547178 @default.
• W2012184356 date "2009-03-01" @default.
• W2012184356 modified "2023-10-17" @default.
• W2012184356 title "Expression of Chemokines and Their Receptors by Human Brain Endothelium: Implications for Multiple Sclerosis" @default.
• W2012184356 cites W116896294 @default.
• W2012184356 cites W1516141774 @default.
• W2012184356 cites W1847201638 @default.
• W2012184356 cites W1963556560 @default.
• W2012184356 cites W1968099474 @default.
• W2012184356 cites W1973867020 @default.
• W2012184356 cites W1978201079 @default.
• W2012184356 cites W1986195187 @default.
• W2012184356 cites W1989528460 @default.
• W2012184356 cites W1992370918 @default.
• W2012184356 cites W2001152609 @default.
• W2012184356 cites W2001660903 @default.
• W2012184356 cites W2005319753 @default.
• W2012184356 cites W2010638326 @default.
• W2012184356 cites W2013307600 @default.
• W2012184356 cites W2013916132 @default.
• W2012184356 cites W2015673958 @default.
• W2012184356 cites W2018114151 @default.
• W2012184356 cites W2019885309 @default.
• W2012184356 cites W2020319641 @default.
• W2012184356 cites W2021538155 @default.
• W2012184356 cites W2023444242 @default.
• W2012184356 cites W2025878623 @default.
• W2012184356 cites W2027148872 @default.
• W2012184356 cites W2036609995 @default.
• W2012184356 cites W2041742400 @default.
• W2012184356 cites W2045151906 @default.
• W2012184356 cites W2045851101 @default.
• W2012184356 cites W2047406653 @default.
• W2012184356 cites W2068918480 @default.
• W2012184356 cites W2076283701 @default.
• W2012184356 cites W2076418667 @default.
• W2012184356 cites W2080932190 @default.
• W2012184356 cites W2081769332 @default.
• W2012184356 cites W2083612980 @default.
• W2012184356 cites W2086196933 @default.
• W2012184356 cites W2086427126 @default.
• W2012184356 cites W2095840153 @default.
• W2012184356 cites W2102862146 @default.
• W2012184356 cites W2107798346 @default.
• W2012184356 cites W2113711862 @default.
• W2012184356 cites W2116495710 @default.
• W2012184356 cites W2124775506 @default.
• W2012184356 cites W2137373716 @default.
• W2012184356 cites W2143408828 @default.
• W2012184356 cites W2169685486 @default.
• W2012184356 cites W2171578272 @default.
• W2012184356 cites W2324329921 @default.
• W2012184356 cites W2442625782 @default.
• W2012184356 cites W4241890711 @default.
• W2012184356 cites W73990037 @default.
• W2012184356 doi "https://doi.org/10.1097/nen.0b013e318197eca7" @default.
• W2012184356 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19225413" @default.
• W2012184356 hasPublicationYear "2009" @default.
• W2012184356 type Work @default.
• W2012184356 sameAs 2012184356 @default.
• W2012184356 citedByCount "86" @default.
• W2012184356 countsByYear W20121843562012 @default.
• W2012184356 countsByYear W20121843562013 @default.
• W2012184356 countsByYear W20121843562014 @default.
• W2012184356 countsByYear W20121843562015 @default.
• W2012184356 countsByYear W20121843562016 @default.
• W2012184356 countsByYear W20121843562017 @default.
• W2012184356 countsByYear W20121843562018 @default.
• W2012184356 countsByYear W20121843562019 @default.
• W2012184356 countsByYear W20121843562020 @default.
• W2012184356 countsByYear W20121843562021 @default.
• W2012184356 countsByYear W20121843562022 @default.
• W2012184356 countsByYear W20121843562023 @default.
• W2012184356 crossrefType "journal-article" @default.
• W2012184356 hasAuthorship W2012184356A5006054229 @default.
• W2012184356 hasAuthorship W2012184356A5013851751 @default.
• W2012184356 hasAuthorship W2012184356A5037523792 @default.
• W2012184356 hasAuthorship W2012184356A5037988586 @default.
• W2012184356 hasAuthorship W2012184356A5043128657 @default.
• W2012184356 hasAuthorship W2012184356A5052362796 @default.
• W2012184356 hasAuthorship W2012184356A5062547178 @default.
• W2012184356 hasBestOaLocation W20121843561 @default.
• W2012184356 hasConcept C116484652 @default.
• W2012184356 hasConcept C12823836 @default.
• W2012184356 hasConcept C13373296 @default.
• W2012184356 hasConcept C164027704 @default.
• W2012184356 hasConcept C17991360 @default.
• W2012184356 hasConcept C203014093 @default.
• W2012184356 hasConcept C25532541 @default.
• W2012184356 hasConcept C2776090121 @default.

• next