FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012185320> ?p ?o ?g. }

• W2012185320 endingPage "186" @default.
• W2012185320 startingPage "186" @default.
• W2012185320 abstract "To evaluate 1) the ability of magnetization transfer ratio (MTR) histogram analysis to detect the extent of changes occurring outside MS lesions seen on conventional scans, 2) whether such changes vary in the different MS clinical phenotypes, 3) whether the changes are associated with the extent and severity of the macroscopic lesion load, and 4) the contribution to brain atrophy.Dual-echo, T1-weighted, and MT scans of the brain were obtained from 77 patients with varying MS courses and 20 age- and sex-matched control subjects. To create MT histograms of the normal-appearing cerebral tissue, MS lesions were segmented from dual-echo scans, superimposed automatically, and nulled out from the coregistered and scalp-stripped MTR maps. Average MTR, peak height, and peak position were considered. T2 and T1 lesion loads, average lesion MTR, and brain volume were also measured.Average histogram MTR (p<0.0001) and peak position (p<0.0001) from patients with relapsing-remitting MS (RMMS) were lower than those from control subjects. Patients with primary progressive MS (PPMS) had lower average histogram MTR (p = 0.002) and histogram peak height (p = 0.01) than control subjects. Patients with secondary progressive MS (SPMS) had a lower peak height (p = 0.05) than those with RRMS. Average lesion MTR (p<0.0001) correlated highly with the histogram MTR. Average histogram MTR (p<0.0001) and T2 lesion load (p = 0.001) correlated highly with brain volume.The amount of microscopic changes account for an important fraction of the lesion load in MS. They may contribute to the development of brain atrophy and tend to be more evident in patients with secondary progressive MS." @default.
• W2012185320 created "2016-06-24" @default.
• W2012185320 creator A5003010065 @default.
• W2012185320 creator A5013583812 @default.
• W2012185320 creator A5018024307 @default.
• W2012185320 creator A5031425622 @default.
• W2012185320 creator A5031754069 @default.
• W2012185320 creator A5048030501 @default.
• W2012185320 creator A5074998862 @default.
• W2012185320 creator A5078205854 @default.
• W2012185320 date "2000-01-11" @default.
• W2012185320 modified "2023-10-17" @default.
• W2012185320 title "A magnetization transfer histogram study of normal-appearing brain tissue in MS" @default.
• W2012185320 cites W1967440018 @default.
• W2012185320 cites W1975921164 @default.
• W2012185320 cites W1976112598 @default.
• W2012185320 cites W1976149684 @default.
• W2012185320 cites W1980261845 @default.
• W2012185320 cites W1981866033 @default.
• W2012185320 cites W1994239940 @default.
• W2012185320 cites W2007090065 @default.
• W2012185320 cites W2015052590 @default.
• W2012185320 cites W2018407557 @default.
• W2012185320 cites W2023180387 @default.
• W2012185320 cites W2026222025 @default.
• W2012185320 cites W2030792741 @default.
• W2012185320 cites W2042906467 @default.
• W2012185320 cites W2045165180 @default.
• W2012185320 cites W2045762174 @default.
• W2012185320 cites W2045923357 @default.
• W2012185320 cites W2047977577 @default.
• W2012185320 cites W2050982154 @default.
• W2012185320 cites W2056291378 @default.
• W2012185320 cites W2058502093 @default.
• W2012185320 cites W2058784068 @default.
• W2012185320 cites W2061110874 @default.
• W2012185320 cites W2069125029 @default.
• W2012185320 cites W2072178771 @default.
• W2012185320 cites W2074111139 @default.
• W2012185320 cites W2078913230 @default.
• W2012185320 cites W2082998828 @default.
• W2012185320 cites W2083934690 @default.
• W2012185320 cites W2087589796 @default.
• W2012185320 cites W2090698554 @default.
• W2012185320 cites W2090748566 @default.
• W2012185320 cites W2091258832 @default.
• W2012185320 cites W2097364877 @default.
• W2012185320 cites W2102993505 @default.
• W2012185320 cites W2112007924 @default.
• W2012185320 cites W2112165124 @default.
• W2012185320 cites W2129794982 @default.
• W2012185320 cites W2134165173 @default.
• W2012185320 cites W2135142396 @default.
• W2012185320 cites W2140547288 @default.
• W2012185320 cites W2145657433 @default.
• W2012185320 cites W2149953041 @default.
• W2012185320 cites W2152317140 @default.
• W2012185320 cites W2166804445 @default.
• W2012185320 cites W2168406554 @default.
• W2012185320 cites W2170360850 @default.
• W2012185320 cites W2189829250 @default.
• W2012185320 cites W2303239603 @default.
• W2012185320 cites W2325038063 @default.
• W2012185320 cites W2438379048 @default.
• W2012185320 cites W2123966979 @default.
• W2012185320 doi "https://doi.org/10.1212/wnl.54.1.186" @default.
• W2012185320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10636146" @default.
• W2012185320 hasPublicationYear "2000" @default.
• W2012185320 type Work @default.
• W2012185320 sameAs 2012185320 @default.
• W2012185320 citedByCount "172" @default.
• W2012185320 countsByYear W20121853202012 @default.
• W2012185320 countsByYear W20121853202013 @default.
• W2012185320 countsByYear W20121853202014 @default.
• W2012185320 countsByYear W20121853202015 @default.
• W2012185320 countsByYear W20121853202016 @default.
• W2012185320 countsByYear W20121853202017 @default.
• W2012185320 countsByYear W20121853202018 @default.
• W2012185320 countsByYear W20121853202019 @default.
• W2012185320 countsByYear W20121853202022 @default.
• W2012185320 crossrefType "journal-article" @default.
• W2012185320 hasAuthorship W2012185320A5003010065 @default.
• W2012185320 hasAuthorship W2012185320A5013583812 @default.
• W2012185320 hasAuthorship W2012185320A5018024307 @default.
• W2012185320 hasAuthorship W2012185320A5031425622 @default.
• W2012185320 hasAuthorship W2012185320A5031754069 @default.
• W2012185320 hasAuthorship W2012185320A5048030501 @default.
• W2012185320 hasAuthorship W2012185320A5074998862 @default.
• W2012185320 hasAuthorship W2012185320A5078205854 @default.
• W2012185320 hasConcept C115961682 @default.
• W2012185320 hasConcept C126838900 @default.
• W2012185320 hasConcept C142724271 @default.
• W2012185320 hasConcept C143409427 @default.
• W2012185320 hasConcept C154945302 @default.
• W2012185320 hasConcept C2781156865 @default.
• W2012185320 hasConcept C2781172350 @default.
• W2012185320 hasConcept C27826641 @default.
• W2012185320 hasConcept C2989005 @default.

• next