FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012185579> ?p ?o ?g. }

• W2012185579 endingPage "662" @default.
• W2012185579 startingPage "655" @default.
• W2012185579 abstract "Primary cilia are microtubule-based solitary sensing structures on the cell surface that play crucial roles in cell signaling and development. Abnormal ciliary function leads to various human genetic disorders, collectively known as ciliopathies. Outer dense fiber protein 2 (Odf2) was initially isolated as a major component of sperm-tail fibers. Subsequent studies have demonstrated the existence of many splicing variants of Odf2, including Cenexin1 (Odf2 isoform 9), which bears an unusual C-terminal extension. Strikingly, Odf2 localizes along the axoneme of primary cilia, whereas Cenexin1 localizes to basal bodies in cultured mammalian cells. Whether Odf2 and Cenexin1 contribute to primary cilia assembly by carrying out either concerted or distinct functions is unknown. By taking advantage of odf2−/− cells lacking endogenous Odf2 and Cenexin1, but exogenously expressing one or both of these proteins, we showed that Cenexin1, but not Odf2, was necessary and sufficient to induce ciliogenesis. Furthermore, the Cenexin1-dependent primary cilia assembly pathway appeared to function independently of Odf2. Consistently, Cenexin1, but not Odf2, interacted with GTP-loaded Rab8a, localized to the distal/subdistal appendages of basal bodies, and facilitated the recruitment of Chibby, a centriolar component that is important for proper ciliogenesis. Taken together, our results suggest that Cenexin1 plays a critical role in ciliogenesis through its C-terminal extension that confers a unique ability to mediate primary cilia assembly. The presence of multiple splicing variants hints that the function of Odf2 is diversified in such a way that each variant has a distinct role in the complex cellular and developmental processes." @default.
• W2012185579 created "2016-06-24" @default.
• W2012185579 creator A5013507111 @default.
• W2012185579 creator A5022976734 @default.
• W2012185579 creator A5027866858 @default.
• W2012185579 creator A5030664816 @default.
• W2012185579 creator A5041197835 @default.
• W2012185579 creator A5042026886 @default.
• W2012185579 creator A5042986993 @default.
• W2012185579 creator A5067249774 @default.
• W2012185579 creator A5069268501 @default.
• W2012185579 creator A5080467464 @default.
• W2012185579 creator A5087888208 @default.
• W2012185579 date "2013-02-15" @default.
• W2012185579 modified "2023-09-26" @default.
• W2012185579 title "Essential role of Cenexin1, but not Odf2, in ciliogenesis" @default.
• W2012185579 cites W1974497457 @default.
• W2012185579 cites W2017960526 @default.
• W2012185579 cites W2021080732 @default.
• W2012185579 cites W2040814134 @default.
• W2012185579 cites W2046374018 @default.
• W2012185579 cites W2056164302 @default.
• W2012185579 cites W2059676290 @default.
• W2012185579 cites W2067914995 @default.
• W2012185579 cites W2087619001 @default.
• W2012185579 cites W2100620635 @default.
• W2012185579 cites W2109402764 @default.
• W2012185579 cites W2119521076 @default.
• W2012185579 cites W2127911585 @default.
• W2012185579 cites W2164927782 @default.
• W2012185579 doi "https://doi.org/10.4161/cc.23585" @default.
• W2012185579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3594266" @default.
• W2012185579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23343771" @default.
• W2012185579 hasPublicationYear "2013" @default.
• W2012185579 type Work @default.
• W2012185579 sameAs 2012185579 @default.
• W2012185579 citedByCount "25" @default.
• W2012185579 countsByYear W20121855792013 @default.
• W2012185579 countsByYear W20121855792014 @default.
• W2012185579 countsByYear W20121855792015 @default.
• W2012185579 countsByYear W20121855792016 @default.
• W2012185579 countsByYear W20121855792018 @default.
• W2012185579 countsByYear W20121855792019 @default.
• W2012185579 countsByYear W20121855792020 @default.
• W2012185579 countsByYear W20121855792021 @default.
• W2012185579 countsByYear W20121855792022 @default.
• W2012185579 countsByYear W20121855792023 @default.
• W2012185579 crossrefType "journal-article" @default.
• W2012185579 hasAuthorship W2012185579A5013507111 @default.
• W2012185579 hasAuthorship W2012185579A5022976734 @default.
• W2012185579 hasAuthorship W2012185579A5027866858 @default.
• W2012185579 hasAuthorship W2012185579A5030664816 @default.
• W2012185579 hasAuthorship W2012185579A5041197835 @default.
• W2012185579 hasAuthorship W2012185579A5042026886 @default.
• W2012185579 hasAuthorship W2012185579A5042986993 @default.
• W2012185579 hasAuthorship W2012185579A5067249774 @default.
• W2012185579 hasAuthorship W2012185579A5069268501 @default.
• W2012185579 hasAuthorship W2012185579A5080467464 @default.
• W2012185579 hasAuthorship W2012185579A5087888208 @default.
• W2012185579 hasBestOaLocation W20121855791 @default.
• W2012185579 hasConcept C100094513 @default.
• W2012185579 hasConcept C104317684 @default.
• W2012185579 hasConcept C10447061 @default.
• W2012185579 hasConcept C115811362 @default.
• W2012185579 hasConcept C131151476 @default.
• W2012185579 hasConcept C1491633281 @default.
• W2012185579 hasConcept C195267511 @default.
• W2012185579 hasConcept C2910722709 @default.
• W2012185579 hasConcept C29537977 @default.
• W2012185579 hasConcept C54355233 @default.
• W2012185579 hasConcept C86803240 @default.
• W2012185579 hasConcept C95444343 @default.
• W2012185579 hasConceptScore W2012185579C100094513 @default.
• W2012185579 hasConceptScore W2012185579C104317684 @default.
• W2012185579 hasConceptScore W2012185579C10447061 @default.
• W2012185579 hasConceptScore W2012185579C115811362 @default.
• W2012185579 hasConceptScore W2012185579C131151476 @default.
• W2012185579 hasConceptScore W2012185579C1491633281 @default.
• W2012185579 hasConceptScore W2012185579C195267511 @default.
• W2012185579 hasConceptScore W2012185579C2910722709 @default.
• W2012185579 hasConceptScore W2012185579C29537977 @default.
• W2012185579 hasConceptScore W2012185579C54355233 @default.
• W2012185579 hasConceptScore W2012185579C86803240 @default.
• W2012185579 hasConceptScore W2012185579C95444343 @default.
• W2012185579 hasIssue "4" @default.
• W2012185579 hasLocation W20121855791 @default.
• W2012185579 hasLocation W20121855792 @default.
• W2012185579 hasLocation W20121855793 @default.
• W2012185579 hasLocation W20121855794 @default.
• W2012185579 hasOpenAccess W2012185579 @default.
• W2012185579 hasPrimaryLocation W20121855791 @default.
• W2012185579 hasRelatedWork W1699988879 @default.
• W2012185579 hasRelatedWork W2043230710 @default.
• W2012185579 hasRelatedWork W2101379984 @default.
• W2012185579 hasRelatedWork W2138310216 @default.
• W2012185579 hasRelatedWork W2138415257 @default.
• W2012185579 hasRelatedWork W2184272884 @default.
• W2012185579 hasRelatedWork W2317540955 @default.

• next