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• W2012186010 abstract "Macrophages bind concanavalin A (ConA) and interiorize the ConA-receptor conjugates in minute ConA-bearing pinosomes that undergo intracellular fusion processes to yield medium size (2–5 μ) and large size (>5 μ) vacuoles. The number and size of the vacuoles depends on ConA concentration and on the composition of the incubation medium. Cytochalasin B (CB) reduces ConA internalization by 30% and the surface bound lectin redistributes to form numerous clumps of fluorescence. Macrophage ConA-induced vacuolation is inhibited by CB both when the incubation is carried out in Dulbecco's modified Eagle's medium (90% inhibition) or in phosphate buffered saline (80% inhibition). Colchicine reduces [3H]ConA internalization by 20% and has no detectable effect on the surface distribution of fluorescein-ConA conjugates. Incubation of macrophages with colchicine prior to or during ConA induction of vacuole formation results in an enhancement of cell vacuolation; the number of the developing large size vacuoles exceeds 4–6-fold that obtained in the absence of the alkaloid. The results suggest the involvement of elements of the cytoskeleton (microfilaments-microtubuli) in regulation of the sequence of events leading to ConA-induced vacuolation and that CB and colchicine have opposite effects on the process." @default.
• W2012186010 created "2016-06-24" @default.
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• W2012186010 date "1976-05-01" @default.
• W2012186010 modified "2023-10-11" @default.
• W2012186010 title "The effect of cytochalasin B and colchicine on concanavalin A induced vacuolation in mouse peritoneal macrophages" @default.
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• W2012186010 doi "https://doi.org/10.1016/0014-4827(76)90596-6" @default.
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