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• W2012186087 abstract "The induction of SCEs and chromosome aberrations in PHA-stimulated human lymphocytes treated in vitro for 70 h with Cr(VI) (potassium dichromate, K2Cr2O7) or Cr(III) (chromium chloride, CrCl3) was determined. A clear dose-dependent increase of the frequency of SCEs is induced by Cr(VI), a 2.5-fold increase being obtained with 10−5 M K2Cr2O7. Cr(III) is, on the other hand, absolutely inactive even when used at sub-toxic concentrations (10−3 M CrCl3). The overall frequency of chromosome aberrations is significantly increased by Cr(VI) above 2.5 × 10−7 M K2Cr2O7, and chromatid-type aberrations (gaps and breaks) are the most frequent. 100 times higher concentrations of CrCl3 are required to increase the frequency of chromosome aberrations. A difference of the same order of magnitude is observed for the cytotoxic activity of Cr(VI) and Cr(III), which is characterized by a slowing down of the mitotic cycle reflected by increased 1st-division and decreased 3rd-division metaphases. By treating unstimulated lymphocytes in vitro with Cr(VI) in the G0 phase, an increase in the frequency of SCEs is produced significantly lower than that obtained on stimulated lymphocytes. Cr(VI) treatments performed at different intervals after stimulation show that the sensitivity of lymphocytes to the induction of SCEs by CR(VI) depends on the phase of the cell cycle, highest frequencies of SCEs being obtained when the cells enter the S phase of DNA replication. The frequency of SCEs in lymphocytes of 12 workers exposed to Cr(VI) (chromic acid fumes in a plating works) is significantly higher than that of 10 control donors. In particular, all the 7 youngest workers, although the most recently engaged in chromium plating, show significantly increased SCE frequencies." @default.
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• W2012186087 date "1982-04-01" @default.
• W2012186087 modified "2023-09-24" @default.
• W2012186087 title "Clastogenic effects of chromium on human lymphocytes in vitro and in vivo" @default.
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• W2012186087 doi "https://doi.org/10.1016/0165-1218(82)90005-2" @default.
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