FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2012189183> ?p ?o ?g. }

• W2012189183 endingPage "4506" @default.
• W2012189183 startingPage "4500" @default.
• W2012189183 abstract "High passive stiffness is one of the characteristic properties of the asynchronous indirect flight muscle (IFM) found in many insects like Drosophila. To evaluate the effects of two thick filament protein domains on passive sarcomeric stiffness, and to investigate their correlation with IFM function, we used microfabricated cantilevers and a high resolution imaging system to study the passive IFM myofibril stiffness of two groups of transgenic Drosophila lines. One group (hinge-switch mutants) had a portion of the endogenous S2 hinge region replaced by an embryonic version; the other group (paramyosin mutants) had one or more putative phosphorylation sites near the N-terminus of paramyosin disabled. Both transgenic groups showed severely compromised flight ability. In this study, we found no difference (compared to the control) in passive elastic modulus in the hinge-switch group, but a 15% reduction in the paramyosin mutants. All results were corroborated by muscle fiber mechanics experiments performed on the same lines. The fact that myofibril elasticity is unaffected by hinge switching implies alternative S2 hinges do not critically affect passive sarcomere stiffness. In contrast, the mechanical defects observed upon disrupting paramyosin phosphorylation sites in Drosophila suggests that paramyosin phosphorylation is important for maintaining high passive stiffness in IFM myofibrils, probably by affecting paramyosin's interaction with other sarcomeric proteins." @default.
• W2012189183 created "2016-06-24" @default.
• W2012189183 creator A5004861439 @default.
• W2012189183 creator A5008928895 @default.
• W2012189183 creator A5018764399 @default.
• W2012189183 creator A5037387408 @default.
• W2012189183 creator A5041763436 @default.
• W2012189183 creator A5057534434 @default.
• W2012189183 creator A5057637759 @default.
• W2012189183 date "2006-12-01" @default.
• W2012189183 modified "2023-10-02" @default.
• W2012189183 title "Passive Stiffness in Drosophila Indirect Flight Muscle Reduced by Disrupting Paramyosin Phosphorylation, but Not by Embryonic Myosin S2 Hinge Substitution" @default.
• W2012189183 cites W1212402145 @default.
• W2012189183 cites W1540034139 @default.
• W2012189183 cites W1906053604 @default.
• W2012189183 cites W1972740202 @default.
• W2012189183 cites W1975289346 @default.
• W2012189183 cites W1980496949 @default.
• W2012189183 cites W1987845152 @default.
• W2012189183 cites W1989398936 @default.
• W2012189183 cites W1995744347 @default.
• W2012189183 cites W2006157095 @default.
• W2012189183 cites W2011748757 @default.
• W2012189183 cites W2012203267 @default.
• W2012189183 cites W2021781539 @default.
• W2012189183 cites W2024645073 @default.
• W2012189183 cites W2025627402 @default.
• W2012189183 cites W2025862538 @default.
• W2012189183 cites W2031667198 @default.
• W2012189183 cites W2042110079 @default.
• W2012189183 cites W2046003039 @default.
• W2012189183 cites W2061697902 @default.
• W2012189183 cites W2062016358 @default.
• W2012189183 cites W2068917225 @default.
• W2012189183 cites W2083668285 @default.
• W2012189183 cites W2088922521 @default.
• W2012189183 cites W2094122561 @default.
• W2012189183 cites W2101008482 @default.
• W2012189183 cites W2108876465 @default.
• W2012189183 cites W2111721810 @default.
• W2012189183 cites W2132581521 @default.
• W2012189183 cites W2147943981 @default.
• W2012189183 cites W2152427924 @default.
• W2012189183 cites W2158250114 @default.
• W2012189183 cites W2161729406 @default.
• W2012189183 cites W2399181552 @default.
• W2012189183 cites W62031580 @default.
• W2012189183 cites W65403125 @default.
• W2012189183 doi "https://doi.org/10.1529/biophysj.106.088492" @default.
• W2012189183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1779912" @default.
• W2012189183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17012313" @default.
• W2012189183 hasPublicationYear "2006" @default.
• W2012189183 type Work @default.
• W2012189183 sameAs 2012189183 @default.
• W2012189183 citedByCount "16" @default.
• W2012189183 countsByYear W20121891832013 @default.
• W2012189183 countsByYear W20121891832018 @default.
• W2012189183 countsByYear W20121891832020 @default.
• W2012189183 countsByYear W20121891832021 @default.
• W2012189183 countsByYear W20121891832023 @default.
• W2012189183 crossrefType "journal-article" @default.
• W2012189183 hasAuthorship W2012189183A5004861439 @default.
• W2012189183 hasAuthorship W2012189183A5008928895 @default.
• W2012189183 hasAuthorship W2012189183A5018764399 @default.
• W2012189183 hasAuthorship W2012189183A5037387408 @default.
• W2012189183 hasAuthorship W2012189183A5041763436 @default.
• W2012189183 hasAuthorship W2012189183A5057534434 @default.
• W2012189183 hasAuthorship W2012189183A5057637759 @default.
• W2012189183 hasBestOaLocation W20121891831 @default.
• W2012189183 hasConcept C104317684 @default.
• W2012189183 hasConcept C11960822 @default.
• W2012189183 hasConcept C12554922 @default.
• W2012189183 hasConcept C127413603 @default.
• W2012189183 hasConcept C143065580 @default.
• W2012189183 hasConcept C159985019 @default.
• W2012189183 hasConcept C174054327 @default.
• W2012189183 hasConcept C185592680 @default.
• W2012189183 hasConcept C192562407 @default.
• W2012189183 hasConcept C205875245 @default.
• W2012189183 hasConcept C207200792 @default.
• W2012189183 hasConcept C2779372316 @default.
• W2012189183 hasConcept C44000306 @default.
• W2012189183 hasConcept C55493867 @default.
• W2012189183 hasConcept C66938386 @default.
• W2012189183 hasConcept C68731436 @default.
• W2012189183 hasConcept C6997183 @default.
• W2012189183 hasConcept C7301908 @default.
• W2012189183 hasConcept C86803240 @default.
• W2012189183 hasConcept C95444343 @default.
• W2012189183 hasConceptScore W2012189183C104317684 @default.
• W2012189183 hasConceptScore W2012189183C11960822 @default.
• W2012189183 hasConceptScore W2012189183C12554922 @default.
• W2012189183 hasConceptScore W2012189183C127413603 @default.
• W2012189183 hasConceptScore W2012189183C143065580 @default.
• W2012189183 hasConceptScore W2012189183C159985019 @default.
• W2012189183 hasConceptScore W2012189183C174054327 @default.
• W2012189183 hasConceptScore W2012189183C185592680 @default.
• W2012189183 hasConceptScore W2012189183C192562407 @default.

• next